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Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline

Autor: G.C. Nascimento, M. Bortolanza, A. Bribian, G.C. Leal-Luiz, R. Raisman-Vozari, L. López-Mascaraque, E. Del-Bel

Publikováno v: ASN Neuro, Vol 15 (2023)

Levo-dihydroxyphenylalanine (L-DOPA) therapy for Parkinson's disease (PD) patients improves motor symptoms, but long-term treatment induces side effects such as abnormal involuntary movements (levodopa-induced dyskinesia – LID). Increasing evidence

Externí odkaz: https://doaj.org/article/325c3c1ead324dae9760baf378d21d24

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Akademický článek

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Akademický článek

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The non-antibiotic tetracycline COL-3 prevents microglial inflammatory responses by reducing glucose-mediated oxidative stress

Autor: Maurício dos-Santos-Pereira, Elaine Aparecida Del Bel, R. Raisman-Vozari, Rosana Chehín, Paola Ramirez, Nilson Carlos Ferreira-Junior, Florencia González-Lizárraga, Nour Francis, Patrick P. Michel

Figure 6: The inhibitory effects of COL-3 on TNF-α release are reproduced by either reducing glucose metabolism or lowering NADPH oxidase activity . (A) Quantification of TNF-α levels in microglial cells exposed or not to LPS (10 ng/ml, 24-h) in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d3957cb19b77824d588f734ec89e2f7
https://doi.org/10.22541/au.162144021.19509352/v1

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Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Autor: Elaine Aparecida Del Bel, Diana F. Lázaro, Nicolas Bizat, Patrick P. Michel, Rosana Chehín, Valeria Parrales, Eftychia Vasili, Antonio Dominguez-Meijide, Tiago F. Outeiro, Annie Lannuzel, Stéphane Haik, Annekatrin König, R. Raisman-Vozari, Florencia González-Lizárraga

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2021, 151, pp.105256. ⟨10.1016/j.nbd.2021.105256⟩
Neurobiology of Disease, Vol 151, Iss, Pp 105256-(2021)
Neurobiology of Disease, 2021, 151, pp.105256. ⟨10.1016/j.nbd.2021.105256⟩
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

International audience; Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04742017d14d77fe2b75dbda119fb1e0
https://hal.sorbonne-universite.fr/hal-03195956/file/1-s2.0-S096999612100005X-main.pdf

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Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity

Autor: Antonio Dominguez-Meijide, Rosana Chehín, Markus Zweckstetter, Florencia González-Lizárraga, Sequeira S, Laura Smeldy Jurado Medina, Tiago F. Outeiro, Del Bel E, Sergio B. Socías, Parrales, Maria-Sol Cima-Omori, R. Raisman-Vozari, Patrick P. Michel, Diego Ploper

Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b503f7ccc8772734c66118f190cca6e
https://doi.org/10.1101/2020.11.18.388561

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CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects

Autor: César Ávila, Diego Ploper, Florencia González-Lizárraga, Belén Machín, Maurício dos-Santos-Pereira, Elaine Del-Bel, Patrick P. Michel, Rosana Chehín, Lía I. Pietrasanta, R. Raisman-Vozari, Sergio B. Socías

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Parkinson's disease (PD) is a neurodegenerative disorder for which only symptomatic treatments are available. Repurposing drugs that target α-synuclein aggregation, considered one of the main drivers of PD progression, could accelerate the developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a8a5ef5fb1e123bfe9bc13c77ffb5c
http://europepmc.org/articles/PMC7679368

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Doxycycline, an anti-inflammatory agent, alleviates dyskinesia induced by L-DOPA in Parkinsonian rats

Autor: Elaine Aparecida Del Bel, Mariza Bortolanza, R. Raisman-Vozari, Glauce Crivelaro do Nascimento

Background and Purpose L-DOPA induced dyskinesia is a debilitating side effect of treating Parkinson’s disease with L-DOPA. There is a need to discover a treatment that has the same benefits as L-DOPA treatment without the associated side effects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9253173a2c4154333727ac3f538d3e20
https://doi.org/10.22541/au.159285563.30385356

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Akademický článek

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