Zobrazeno 1 - 10
of 46
pro vyhledávání: '"R. R. Lobb"'
Publikováno v:
The Journal of Experimental Medicine
This report examines the effect of an anti-VLA-4 monoclonal antibody (mAb) HP1/2 on antigen-induced bronchial hyperreactivity to methacholine, and on eosinophil and T lymphocyte infiltration in the airways of guinea pigs sensitized and challenged by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009ef9bdd005b53427013a71a870c4d5
http://europepmc.org/articles/PMC2191648
http://europepmc.org/articles/PMC2191648
Publikováno v:
The Journal of Experimental Medicine
Using an in vivo test system, the role of the beta 1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated. Eosinophil infiltration and edema formation were meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fd9866974b487def2cf0f40132ec99
https://doi.org/10.1084/jem.177.2.561
https://doi.org/10.1084/jem.177.2.561
Publikováno v:
The Journal of Immunology. 148:2395-2404
Treatment of vascular endothelial cells with inflammatory cytokines stimulates surface expression of E-selectin (previously known as endothelial-leukocyte adhesion molecule-1) and promotes the transendothelial migration of neutrophils. To assess part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eb5367a71f80ab906e8956485fdf559
https://doi.org/10.4049/jimmunol.148.8.2395
https://doi.org/10.4049/jimmunol.148.8.2395
Autor:
R R Lobb, G Chi-Rosso, D R Leone, M D Rosa, S Bixler, B M Newman, S Luhowskyj, C D Benjamin, I G Dougas, S E Goelz
Publikováno v:
The Journal of Immunology. 147:124-129
Endothelial leukocyte adhesion molecule 1 (ELAM1) is a leukocyte adhesion molecule induced on human venular endothelium in vitro and in vivo by inflammatory stimuli. A truncated cDNA for ELAM1 has been constructed, stably expressed in Chinese hamster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::229cc89036ec923851d15e4b0f417622
https://doi.org/10.4049/jimmunol.147.1.124
https://doi.org/10.4049/jimmunol.147.1.124
Autor:
M, Labinaz, C, Hoffert, K, Pels, S, Aggarwal, R B, Pepinsky, D, Leone, V, Koteliansky, R R, Lobb, E R, O'Brien
Publikováno v:
The Canadian journal of cardiology. 16(2)
The alpha4beta1 (or very late antigen-4 [VLA-4]) integrin is thought to play a role in inflammatory processes, mediating mononuclear leukocyte infiltration. The adventitial response to balloon injury is an important determinant of neointimal formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e33b6f651d8c167acac2ddc362b371f
https://pubmed.ncbi.nlm.nih.gov/10694589
https://pubmed.ncbi.nlm.nih.gov/10694589
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(9)
The migration of leukocytes into glomeruli in crescentic glomerulonephritis is fundamental to pathogenesis, and offers important therapeutic opportunities. We addressed the importance of VCAM-1, and its leukocyte ligand very late antigen-4 (VLA-4), i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ab2adf1a2bc334096436fc1d38b1eac
https://pubmed.ncbi.nlm.nih.gov/10228033
https://pubmed.ncbi.nlm.nih.gov/10228033
Autor:
R R, Lobb, W M, Abraham, L C, Burkly, A, Gill, W, Ma, J A, Knight, D R, Leone, G, Antognetti, R B, Pepinsky
Publikováno v:
Annals of the New York Academy of Sciences. 796
Evidence for a central role for the integrins alpha 4 beta 1 and alpha 4 beta 7 in leukocyte pathophysiology is rapidly accumulating. Five distinct alpha 4 mAbs, each able to block alpha 4-dependent adhesion in vitro, show beneficial effects in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23a43936db6479e6751d7cd278379c78
https://pubmed.ncbi.nlm.nih.gov/8906218
https://pubmed.ncbi.nlm.nih.gov/8906218
Publikováno v:
The European respiratory journal. Supplement. 22
The alpha 4 integrins are heterodimeric leucocyte cell surface molecules central to their cell and matrix adhesive interactions. The integrin alpha 4 beta 1 interacts with the immunoglobulin superfamily member vascular cell adhesion molecule-1 (VCAM-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::745a87151288b29f02bf8840eda1ca62
https://pubmed.ncbi.nlm.nih.gov/8871053
https://pubmed.ncbi.nlm.nih.gov/8871053
Publikováno v:
The Journal of biological chemistry. 270(24)
Integrin alpha 4 beta 1 is a leukocyte receptor for fibronectin and vascular cell adhesion molecule-1 (VCAM-1). It is important in inflammatory recruitment of leukocytes, lymphopoiesis, and a number of development events. Here we have mapped a panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20026207065fbd827c485ab37aeeb284
https://pubmed.ncbi.nlm.nih.gov/7782282
https://pubmed.ncbi.nlm.nih.gov/7782282
Autor:
T. Tegoshi, M. Ho, M. Aikawa, Y. Maeno, Y. Thway, Christian F. Ockenhouse, C. Benjamin, R. R. Lobb, K. Win, Khin Ei Kan
Publikováno v:
The Journal of Experimental Medicine
The clinical complications associated with severe and cerebral malaria occur as a result of the intravascular mechanical obstruction of erythrocytes infected with the asexual stages of the parasite, Plasmodium falciparum. We now report that a primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1202755f118518b31a657b7e2a76ab30
https://pubmed.ncbi.nlm.nih.gov/1383378
https://pubmed.ncbi.nlm.nih.gov/1383378