Zobrazeno 1 - 10
of 251
pro vyhledávání: '"R. R. Hardy"'
Publikováno v:
Cytometry. 45:47-55
While several algorithms for the comparison of univariate distributions arising from flow cytometric analyses have been developed and studied for many years, algorithms for comparing multivariate distributions remain elusive. Such algorithms could be
Publikováno v:
The Journal of Immunology. 158:1133-1138
The enzyme terminal deoxynucleotidyl transferase (TdT) adds nontemplate-derived nucleotides (N regions) to the junctions between recombining variable, diversity, and joining segments of Ig genes. The relative paucity of N regions in Ig light chains,
Publikováno v:
International Immunology. 7:1637-1647
Myc family proteins are thought to be transcription factors involved in regulation of cell growth and differentiation. N-myc is expressed at the pre-B cell stage of B cell differentiation and is dramatically induced by the pre-B cell growth factor, I
Publikováno v:
The Journal of Immunology. 155:644-651
Expression of Ig transgenes in recombination-deficient mutant scid and Rag-1-mice results in the generation of pre-B and B cells, which are normally absent from these animals. In screening for protein tyrosine kinases (PTKs) that may play a role in t
Publikováno v:
The Journal of Immunology. 147:3623-3631
Our laboratory has previously investigated the relationship of autoimmune disease and B cell neoplasia in a patient with a diffuse, well differentiated splenic B cell lymphoma and associated autoimmune hemolysis due to an anti-Pr2 antibody. EBV-immor
Autor:
D. F. Friedman, Leslie E. Silberstein, Condie E. Carmack, J Goldman, E. C. Besa, R. R. Hardy, Eun Ah Cho
Publikováno v:
The Journal of Experimental Medicine
To study the association of autoimmunity and human B cell neoplasia, we have established a model of a B cell lymphoma which expresses a pathogenic autoantibody of defined specificity. The Ig VH gene expressed in this neoplasm was analyzed longitudina
Autor:
D N Ernst, M V Hobbs, B E Torbett, A L Glasebrook, M A Rehse, K Bottomly, K Hayakawa, R R Hardy, W O Weigle
Publikováno v:
The Journal of Immunology. 145:1295-1302
Previous studies indicate that the 3G11, CD45RB, and Pgp-1 determinants are differentially expressed on CD4+ T cell subsets in the mouse. We used multicolor immunofluorescence staining and flow cytofluorometric analysis to examine the expression of e
Autor:
M, Roederer, R R, Hardy
Publikováno v:
Cytometry. 45(1)
In multivariate distributions (for example, in 3- or more color flow cytometric datasets), it can become difficult or impossible to identify populations that differ between samples based only on a combination of univariate or bivariate displays. Inde
Publikováno v:
Current topics in microbiology and immunology. 252
Publikováno v:
Current topics in microbiology and immunology. 252
The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a longstanding puzzle in immunology. In the past few years it has become clear that production of mu heavy chain and subsequent assembly with surroga