Zobrazeno 1 - 10 of 1 150 pro vyhledávání: '"R. R. Hall"'
1
Akademický článek
MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma
Autor: Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R. R. Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F. Ochsenbein, Thomas M. Marti, Gregor J. Kocher, Ralph A. Schmid, Patrick Dorn, Ren-Wang Peng
Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Malignant pleural mesothelioma (MPM) is a lethal malignancy etiologically caused by asbestos exposure, for which there are few effective treatment options. Although asbestos carcinogenesis is associated with reactive oxygen species (ROS), th
Externí odkaz: https://doaj.org/article/5254c7ce468140869bc77e5e71f90aa3
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2
Akademický článek
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis
Autor: Duo Xu, Shun-Qing Liang, Zhang Yang, Haitang Yang, Rémy Bruggmann, Simone Oberhaensli, Sabina Berezowska, Thomas M. Marti, Sean R. R. Hall, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng
Publikováno v: Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Escape from programmed cell death is a hallmark of cancer. In this study, we investigated the anti-apoptotic mechanisms and explored the therapeutic potential of BCL-2 homology domain-3 (BH3) mimetics in malignant pleural mesothelioma (MPM),
Externí odkaz: https://doaj.org/article/aa350021d9954b389e7fe2530bd9522a
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3
Akademický článek
Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)
Autor: Yanyun Gao, Philipp Zens, Min Su, Camila Anna Gemperli, Haitang Yang, Haibin Deng, Zhang Yang, Duo Xu, Sean R. R. Hall, Sabina Berezowska, Patrick Dorn, Ren-Wang Peng, Ralph Alexander Schmid, Wenxiang Wang, Thomas Michael Marti
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-22 (2021)
Abstract Background Pemetrexed (MTA) plus cisplatin combination therapy is considered the standard of care for patients with advanced non-small-cell lung cancer (NSCLC). However, in advanced NSCLC, the 5-year survival rate is below 10%, mainly due to
Externí odkaz: https://doaj.org/article/77898471515947d0a1e1ce7aa86c96c0
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4
Akademický článek
Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer
Autor: Haitang Yang, MD-PhD, Beibei Sun, Ke Xu, Yunfei He, Tuo Zhang, Sean R R Hall, Swee T. Tan, Ralph A. Schmid, Ren-Wang Peng, Guohong Hu, Feng Yao, MD-PhD
Publikováno v: EBioMedicine, Vol 69, Iss , Pp 103457- (2021)
Background: Histone acetylation/deacetylase process is one of the most studied epigenetic modifications. Histone deacetylase inhibitors (HDACis) have shown clinical benefits in haematological malignancies but failed in solid tumours due to the lack o
Externí odkaz: https://doaj.org/article/eeb3790794db40069a031dcc134a184d
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5
Akademický článek
Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection.
Autor: Melanie Brügger, Thomas Démoulins, G Tuba Barut, Beatrice Zumkehr, Blandina I Oliveira Esteves, Kemal Mehinagic, Quentin Haas, Aline Schögler, Marie-Anne Rameix-Welti, Jean-François Eléouët, Ueli Moehrlen, Thomas M Marti, Ralph A Schmid, Artur Summerfield, Horst Posthaus, Nicolas Ruggli, Sean R R Hall, Marco P Alves
Publikováno v: PLoS Pathogens, Vol 17, Iss 7, p e1009789 (2021)
Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highly prevalent
Externí odkaz: https://doaj.org/article/8c6f6bd720c842c1b4ee5c5c8a900c17
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6
Akademický článek
Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment
Autor: Yanyun Gao, Patrick Dorn, Shengchen Liu, Haibin Deng, Sean R. R. Hall, Ren-Wang Peng, Ralph A. Schmid, Thomas M. Marti
Publikováno v: Cancer Cell International, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Cisplatin plus pemetrexed combination therapy is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer (NSCLC). However, advanced NSCLC has a 5-year survival rate of below 10%, whic
Externí odkaz: https://doaj.org/article/771e52eeb8d044dcbefe6075fc730568
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7
Akademický článek
Cell Populations Expressing Stemness-Associated Markers in Vascular Anomalies
Autor: Ethan J. Kilmister, Lauren Hansen, Paul F. Davis, Sean R. R. Hall, Swee T. Tan
Publikováno v: Frontiers in Surgery, Vol 7 (2021)
Treatment of vascular anomalies (VAs) is mostly empirical and, in many instances unsatisfactory, as the pathogeneses of these heterogeneous conditions remain largely unknown. There is emerging evidence of the presence of cell populations expressing s
Externí odkaz: https://doaj.org/article/d44b8dc4b8b947e2a13bee716dc09cf5
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8
Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks
Autor: Ke Xu, Jie Ma, Sean R. R. Hall, Ren-Wang Peng, Haitang Yang, Feng Yao
Publikováno v: Xu, Ke; Ma, Jie; Hall, Sean R R; Peng, Ren-Wang; Yang, Haitang; Yao, Feng (2023). Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks. Theranostics, 13(2), pp. 704-723. Ivyspring International 10.7150/thno.80184
The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2 (KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis, protecting cells from oxidative stress and xenobiotics under physiological circumstance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5ed36f9f79e074fff7efb446ae3a5
https://boris.unibe.ch/177349/1/v13p0704.pdf
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10
Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma
Autor: Haitang Yang, Beibei Sun, Liwen Fan, Wenyan Ma, Ke Xu, Sean R. R. Hall, Zhexin Wang, Ralph A. Schmid, Ren-Wang Peng, Thomas M. Marti, Wen Gao, Jianlin Xu, Weiwei Yang, Feng Yao
Publikováno v: Yang, Haitang; Sun, Beibei; Fan, Liwen; Ma, Wenyan; Xu, Ke; Hall, Sean R R; Wang, Zhexin; Schmid, Ralph A; Peng, Ren-Wang; Marti, Thomas M; Gao, Wen; Xu, Jianlin; Yang, Weiwei; Yao, Feng (2022). Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma. Theranostics, 12(7), pp. 3104-3130. Ivyspring International 10.7150/thno.69590
Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor post-surgical course after curative surgery. However, biomarkers stratifying this high-risk subset and molecular underpinnings underlying the aggressive phenotype
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ada19dcd872d9d4d349b9c322a53ff
https://boris.unibe.ch/170033/1/v12p3104.pdf
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