Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R. R. HINSHAW"'
Autor:
Lester A. Dolak, Johnson Paul D, Chong Kt, Harvey Irving Skulnick, Paul K. Tomich, Michael John Bohanon, Strohbach Joseph Walter, Suvit Thaisrivongs, Steve Turner, K. D. Watenpaugh, M.‐M. Horng, M.N. Janakiraman, R. R. Hinshaw, Paul A. Aristoff, J. C. Lynn, Eric P. Seest, Tommasi Ruben A
Publikováno v:
Journal of Medicinal Chemistry. 41:3467-3476
A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease. Subsequent modification of this lead through iterative cycles of structure-based design led to the activity enhancements of
Autor:
D D Ho, P J Pagano, K T Chong, W. G. Tarpley, T J Dueweke, D E Slade, rd R R Gorman, S M Poppe, M Markowitz, S Thaisrivongs, R. R. Hinshaw, H Mo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:1058-1063
PNU-140690 is a member of a new class of nonpeptidic human immunodeficiency virus (HIV) protease inhibitors (sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones) discovered by structure-based design. PNU-140690 has excellent potency against a vari
Autor:
Gordon L. Bundy, Harvey Irving Skulnick, L. N. Toth, Johnson Paul D, Theresa M. Schwartz, Paul K. Tomich, Strohbach Joseph Walter, J. C. Lynn, Thomas J. Raub, G. E. Padbury, R. R. Hinshaw, Kong Teck Chong, Suvit Thaisrivongs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:399-402
The sulfonamide substituted pyranones ( 1 ) have recently been shown to be potent HIV protease inhibitors. We prepared a series of sulfone substituted analogs and compared their biological activities to those of the corresponding sulfonamide analogs.
Autor:
J. C. Lynn, Tommasi Ruben A, Johnson Paul D, Strohbach Joseph Walter, R. R. Hinshaw, M.N. Janakiraman, Chong Kt, Turner, Paul A. Aristoff, Morge Rr, Howe Wj, Tomich Pk, Donna L. Romero, M.‐M. Horng, Barry C. Finzel, Carolyn Biles, K. D. Watenpaugh, Suvit Thaisrivongs
Publikováno v:
Journal of Medicinal Chemistry. 39:4630-4642
From a broad screening program, the 4-hydroxycoumarin phenprocoumon (I) was previously identified as a lead template with HIV protease inhibitory activity. The crystal structure of phenprocoumon/HIV protease complex initiated a structure-based design
Autor:
S, Thaisrivongs, M N, Janakiraman, K T, Chong, P K, Tomich, L A, Dolak, S R, Turner, J W, Strohbach, J C, Lynn, M M, Horng, R R, Hinshaw, K D, Watenpaugh
Publikováno v:
Journal of Medicinal Chemistry. 39:2400-2410
The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously id
Autor:
R. R. Hinshaw, M.‐M. Horng, W. Jeffrey Howe, David J. Anderson, and Steve R. Turner, Chong Kt, Steve A. Mizsak, Jeanette Kay Morris, Paul K. Tomich, Strohbach Joseph Walter, Karen Rene Romines
Publikováno v:
Journal of Medicinal Chemistry. 39:4125-4130
Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1-phenylpropyl) derivatives with various cycloalkyl ring sizes, the cyclooctyl analog was the most potent. W
Publikováno v:
Bioorganic Chemistry. 23:499-511
The galactosylceramide lipid is recognized and tightly complexed by the HIV-1 membrane glycoprotein gp120 in the initial step of viral infection of certain cells. The incorporation of an antiviral agent into this lipid offers the opportunity to targe
Autor:
Strohbach Joseph Walter, Lester A. Dolak, K. A. Curry, A.M. Mulichak, Steve Turner, Chong Kt, D. J. Rothrock, M.N. Janakiraman, M.‐M. Horng, Che-Shen C. Tomich, Suvit Thaisrivongs, R. R. Hinshaw, Paul K. Tomich, J. C. Lynn, W. J. Howe, Joseph B. Moon, K. D. Watenpaugh, A G Tomasselli
Publikováno v:
ChemInform. 26
Autor:
Chong Kt, J. C. Lynn, Paul K. Tomich, Karen Rene Romines, M.‐M. Horng, Lester A. Dolak, Howe Wj, Joel Morris, K. D. Lovasz, R. R. Hinshaw, K. D. Watenpaugh, M.N. Janakiraman
Publikováno v:
ChemInform. 27
Autor:
S. THAISRIVONGS, M. N. JANAKIRAMAN, K.-T. CHONG, P. K. TOMICH, L. A. DOLAK, S. R. TURNER, J. W. STROHBACH, J. C. LYNN, M.-M. HORNG, R. R. HINSHAW, K. D. WATENPAUGH
Publikováno v:
ChemInform. 27