Zobrazeno 1 - 10
of 267
pro vyhledávání: '"R. R. Gorman"'
Autor:
D D Ho, P J Pagano, K T Chong, W. G. Tarpley, T J Dueweke, D E Slade, rd R R Gorman, S M Poppe, M Markowitz, S Thaisrivongs, R. R. Hinshaw, H Mo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:1058-1063
PNU-140690 is a member of a new class of nonpeptidic human immunodeficiency virus (HIV) protease inhibitors (sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones) discovered by structure-based design. PNU-140690 has excellent potency against a vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df736ec299e4d25ad33f97274f0768a6
https://doi.org/10.1128/aac.41.5.1058
https://doi.org/10.1128/aac.41.5.1058
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(1)
We examined a series of 2-aminochromone analogs typified by U-84569 [8-methyl-2-(4-morpholinyl)-7-(1-naphthylenylmethoxy)-4H-1- benzopyran-4-one] as potential antithrombotic agents. U-84569 proved to be a potent inhibitor of human platelet aggregatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::421c5a00b792695b55ee4f1f9122cf64
https://pubmed.ncbi.nlm.nih.gov/7682615
https://pubmed.ncbi.nlm.nih.gov/7682615
Publikováno v:
Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury ISBN: 9781461367277
Over the past 20 years, the prostaglandin H synthase (PGHS) (EC 1.14.99.1) has been one of the most heavily studied enzymes in lipid biochemistry (1–3). The purified enzyme is a homodimer of 70-kDa subunits that contain 3.5% carbohydrate of the hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e39047246ec7012307b295776bfe4bd3
https://doi.org/10.1007/978-1-4615-3874-5_44
https://doi.org/10.1007/978-1-4615-3874-5_44
Publikováno v:
Advances in prostaglandin, thromboxane, and leukotriene research.
1. rPDGF stimulates PGE2 release in wild type, but not ras transformed NIH-3T3 cells. 2. Ras transformation blocks PGE2 release by inhibiting phospholipase C activation, IP3 synthesis, and Ca2+ mobilization. 3. rPDGF stimulation of wild type NIH-3T3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd34eff7af4bd656d92424628459f3f5
https://pubmed.ncbi.nlm.nih.gov/1825590
https://pubmed.ncbi.nlm.nih.gov/1825590
Publikováno v:
Methods in enzymology. 187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b8cd1f09d081aee1335ce2925839970
https://pubmed.ncbi.nlm.nih.gov/2233361
https://pubmed.ncbi.nlm.nih.gov/2233361
Publikováno v:
Journal of Biological Chemistry. 264:17379-17383
Stimulation of serum-starved NIH-3T3 cells with 20 ng/ml recombinant platelet-derived growth factor BB (rPDGF) results in the synthesis of prostaglandin E2 (PGE2) that is detectable within 10 min and which peaks after 2 h. Inhibition of translation w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb9b5004c0d8adabe7500defda6472e
https://doi.org/10.1016/s0021-9258(18)71504-4
https://doi.org/10.1016/s0021-9258(18)71504-4
Publikováno v:
Journal of Biological Chemistry. 260:14208-14213
Exposure of HL-60 cells for 6 days to a combination of 1.25% (v/v) dimethyl sulfoxide and 10 microM dexamethasone induces myeloid differentiation which results in a cell with many of the characteristics of a mature granulocyte. At 4 degrees C myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18a03fedd995809b64b5e0b05eb393d
https://doi.org/10.1016/s0021-9258(17)38704-5
https://doi.org/10.1016/s0021-9258(17)38704-5
Publikováno v:
Journal of Biological Chemistry. 259:14048-14053
Incubation of cultured human umbilical vein endothelial cells with [1-14C]arachidonic acid, followed by reverse-phase high-pressure liquid chromatography analysis, results in the appearance of two principal radioactive products besides 6-keto-prostag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08506c38883849f812378d9a01f45007
https://doi.org/10.1016/s0021-9258(18)89853-2
https://doi.org/10.1016/s0021-9258(18)89853-2
Publikováno v:
Journal of Biological Chemistry. 254:1671-1676
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690068285d3261a8593c90e5970c7639
https://doi.org/10.1016/s0021-9258(17)37825-0
https://doi.org/10.1016/s0021-9258(17)37825-0
Publikováno v:
The Journal of Clinical Pharmacology. 29:53-58
Furegrelate sodium (U-63,557A), a pyridine-derivative thromboxane synthase inhibitor, was administered orally in single doses of 200 to 1600 mg to normal male subjects. Furegrelate produced a dose-related inhibition of thromboxane synthesis for 8-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6543cd6b6e05412226da2aca75a37e0
https://doi.org/10.1002/j.1552-4604.1989.tb03237.x
https://doi.org/10.1002/j.1552-4604.1989.tb03237.x