Výsledky vyhledávání - "R. R. Erickson"

Catalysis of the cysteine conjugation and protein binding of acetaminophen by microsomes from a human lymphoblast line transfected with the cDNAs of various forms of human cytochrome P450

Autor: L, Zhou, R R, Erickson, J P, Hardwick, S S, Park, S A, Wrighton, J L, Holtzman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 281(2)

We have previously found that for acetaminophen kinetic differences exist between the hepatic microsomal catalyzed protein binding and cysteine conjugation. We have also observed that the protein binding of acetaminophen is only to intralumenal prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ad54f1c4474571cc2151c189872510f
https://pubmed.ncbi.nlm.nih.gov/9152386

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Clinical evaluation of a flat-plate membrane plasma exchange system

Autor: J. Buchanan, George W. Buffaloe, W. B. Benny, L. Grossman, R. R. Erickson

Publikováno v: Journal of Clinical Apheresis. 1:225-237

A new flat-plate membrane plasma separation system specifically designed for therapeutic plasma exchange (TPE) was clinically evaluated in both research and routine clinical settings. The study included a comparison to a currently available centrifug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55026003e055880f48a20f285f674bc
https://doi.org/10.1002/jca.2920010406

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The kinetics of ethylmorphine N-demethylation in isolated hepatocytes: the effect of drug transport and oxygen concentration

Autor: R R, Erickson, P, Yu-Drent, J L, Holtzman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 220(1)

In previous studies we have observed that the Km for ethylmorphine N-demethylase was only 50 to 100 microM in the isolated hepatocyte as opposed to 250 to 340 microM in isolated microsomes. These data suggested that either the drug is actively transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f90c74afcb3f31985ca8745bb19ded3
https://pubmed.ncbi.nlm.nih.gov/7053421

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The effect of NADH and low oxygen pressure on the hepatic microsomal ethylmorphine N-demethylase activity of the male rat

Autor: J L, Holtzman, J E, Gander, R R, Erickson

Publikováno v: The Journal of biological chemistry. 258(9)

Plots of reciprocal initial rate of formaldehyde formation as a function of reciprocal ethylmorphine concentration provide parallel lines for oxygen concentrations ranging from 5.41 to 211 microM, and the apparent Km values for ethylmorphine at these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1df8c1c49091312dda51254d61284ddd
https://pubmed.ncbi.nlm.nih.gov/6853522

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The role of NADPH- and reduced glutathione-dependent enzymes in the norepinephrine modulation of the ATP-dependent, hepatic microsomal calcium pump: a new pathway for the noradrenergic regulation of cytosolic calcium in the hepatocyte

Autor: R R, Erickson, J S, Prasad, J L, Holtzman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 242(2)

The authors have recently found that the hepatic, microsomal ATP-dependent Ca++ pump activity is decreased through oxidation by cytochrome P-450-generated reactive oxygen species. This inhibition is reversed by reduced glutathione and only partially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cad366e42429d3c9f52247294667479d
https://pubmed.ncbi.nlm.nih.gov/2441031

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The effect of exogenous intrauterine progesterone on the amount and prostaglandin F2alpha content of menstrual blood in dysmenorrheic women

Autor: G, Trobough, A M, Guderian, R R, Erickson, S A, Tillson, P, Leong, D A, Swisher, B B, Pharriss

Publikováno v: The Journal of reproductive medicine. 21(3)

Women with complaints of moderate or severe dysmenorrhea received intrauterine progesterone contraceptive system (16 patients) or placebo systems releasing no hormone (8 patients). Tampons were collected during the period prior to insertion and from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7accdfea6cb3e954517c894e36fc286a
https://pubmed.ncbi.nlm.nih.gov/722696

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