Zobrazeno 1 - 10
of 146
pro vyhledávání: '"R. Principe"'
Autor:
Kanchan Vishnoi, Rong Ke, Navin Viswakarma, Piush Srivastava, Sandeep Kumar, Subhasis Das, Sunil Kumar Singh, Daniel R. Principe, Ajay Rana, Basabi Rana
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-16 (2022)
Abstract The incidence and mortality of hepatocellular carcinoma (HCC) are on a rise in the Western countries including US, attributed mostly to late detection. Sorafenib has been the first-line FDA-approved drug for advanced unresectable HCC for alm
Externí odkaz:
https://doaj.org/article/3ffdf7ee46924e22ae8d4086e6cc67db
Autor:
Daniel R. Principe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and are now the preferred treatment for several tumor types. Though ICIs have shown remarkable efficacy in several cancer histologies, in many cases providing long-term d
Externí odkaz:
https://doaj.org/article/7da5091a08404c72bb81aa7a244707a6
Leukocyte subtyping predicts for treatment failure and poor survival in anal squamous cell carcinoma
Autor:
Daniel R. Principe, Jose L. Cataneo, Kaytlin E. Timbers, Regina M. Koch, Klara Valyi-Nagy, Anders Mellgren, Ajay Rana, Gerald Gantt
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Anal squamous cell carcinoma (SCC) generally carries a favorable prognosis, as most tumors are highly sensitive to standard of care chemoradiation. However, outcomes are poor for the 20–30% of patients who are refractory to this
Externí odkaz:
https://doaj.org/article/1872c77f448f476eb4fec216994be067
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 4, Pp n/a-n/a (2022)
Abstract Lung cancer is the leading cause of cancer‐related death worldwide and is strongly associated with tobacco smoke exposure. Although smoking remains the most important and best studied risk factor, recent data suggest that several other car
Externí odkaz:
https://doaj.org/article/ecce47355f3b4901837f4ecf707a6412
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104380- (2022)
Summary: Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for solid tumors. However, even in cancers generally considered ICI-sensitive, responses can vary significantly. Thus, there is an ever-increasing interest in identi
Externí odkaz:
https://doaj.org/article/2bbc00f275054634bdc2bee09c879481
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Oral iron supplements are commonly administered to patients with chronic iron deficiency anemia. This approach is generally well-tolerated, causing only mild adverse effects. Rarely, oral iron supplementation can cause more severe symptoms, one of th
Externí odkaz:
https://doaj.org/article/eff4833ae9c2494e85a6a84f5cf51f71
Autor:
Daniel R. Principe
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. Although overall outcomes have improved in recent decades, metastatic disease is associated with a particularly poor prognosis, underscoring a need to both ident
Externí odkaz:
https://doaj.org/article/cbce58f3c0c0456f9e15756ab0fd9ac2
Autor:
Thao N.D. Pham, Christina Spaulding, Mario A. Shields, Anastasia E. Metropulos, Dhavan N. Shah, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem, Hidayatullah G. Munshi
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
To elicit effective antitumor responses, CD8+ T cells need to infiltrate tumors and sustain their effector function within the immunosuppressive tumor microenvironment (TME). Here, we evaluate the role of MNK activity in regulating CD8+ T cell infilt
Externí odkaz:
https://doaj.org/article/1a09d8a5ba8e4f9fab3e3efe9e16fad1
Autor:
Daniel R. Principe, Patrick W. Underwood, Sandeep Kumar, Kaytlin E. Timbers, Regina M. Koch, Jose G. Trevino, Hidayatullah G. Munshi, Ajay Rana
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in select immunotherapy regimens shows early promise. Though the TGFβ target SMAD4 is deleted
Externí odkaz:
https://doaj.org/article/588723c078b64673a53deefd38e7bbc1
Autor:
E. Todesco, S. Izquierdo Bermudez, A. Foussat, E. Gautheron, G. Kirby, H. Felice, J. C. Perez, J. Fleiter, C. Barth, A. Milanese, H. Prin, N. Lusa, J. Ferradas Troitino, S. Ferradas Troitino, F. Mangiarotti, R. Principe, G. Willering, D. Duarte Ramos, A. Ballarino, S. Russenschuck, A. Devred, M. Bednarek, F. Rodriguez-Mateos, M. Statera, M. Prioli, M. Sorbi, S. Mariotto, S. Farinon, A. Bersani, B. Caiffi, P. Fabbricatore, F. Levi, A. Pampaloni, F. Toral, C. Martins, J. Garcia Matos, T. Nakamoto, M. Sugano, K. Suzuki, Q. Xu, Y. Wang, W. Wei, G. Apollinari, R. Carcagno, S. Feher, G. Ambrosio, M. Baldini, M. Yu, A. Nobrega, A. Vouris, G. Chlachidze, S. Stoynev, K. Amm, J. Schmalzle, M. Anarella, J. Muratore, A. Ben Yahia, P. Joshi, P. Ferracin, S. Prestemon, D. Cheng, T. Strauss, L. Cooley
Publikováno v:
IEEE Transactions on Applied Superconductivity. 33:1-8
About one hundred magnets of six different types shall be installed in the High Luminosity LHC (HL-LHC) in the years 2026-2028 at CERN. The magnets design, construction and test are based on CERN collaborations with institutes and industrial partners
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea60abb356f1fb1a96d3fffc0b9906e
https://doi.org/10.1109/tasc.2023.3244143
https://doi.org/10.1109/tasc.2023.3244143