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Akademický článek

Inflammasome Activation in an In Vitro Sepsis Model Recapitulates Increased Monocyte Distribution Width Seen in Patients With Sepsis

Autor: Gregory J. Eisinger, MD, MSSW, Wissam Osman, BS, Evan R. Prather, BS, Mark W. Julian, MS, Mikhail A. Gavrilin, PhD, Elliott D. Crouser, MD, Mark D. Wewers, MD

Publikováno v: Critical Care Explorations, Vol 4, Iss 2, p e0631 (2022)

OBJECTIVES:. Increased monocyte distribution width (MDW) has recently been shown to be a reliable indicator of early sepsis detection. This study therefore sought to determine if inflammasome activation can be linked to monocyte size changes in sepsi

Externí odkaz: https://doaj.org/article/580ea3e2caa841c598066c52471edd94

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Akademický článek

Inflammasome Adaptor ASC Is Highly Elevated in Lung Over Plasma and Relates to Inflammation and Lung Diffusion in the Absence of Speck Formation

Autor: Mikhail A. Gavrilin, Christian C. McAndrew, Evan R. Prather, MuChun Tsai, Carleen R. Spitzer, Min-Ae Song, Srabani Mitra, Anasuya Sarkar, Peter G. Shields, Philip T. Diaz, Mark D. Wewers

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of ca

Externí odkaz: https://doaj.org/article/1d59a9fb897c418a97241b94182ae790

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The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state

Autor: Evan R. Prather, Mikhail A. Gavrilin, Mark D. Wewers

Publikováno v: The Journal of biological chemistry. 298(6)

Apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) is a 22 kDa protein that functions as the central adaptor for inflammasome assembly. ASC forms insoluble specks in monocytes undergoing pyroptosis, and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1acb9b7098634e4f46125002caaf340
https://pubmed.ncbi.nlm.nih.gov/35568196

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Making the Invisible Visible: Intervening on cumulative environmental neurodevelopmental risks using a system dynamics approach

Autor: E. Hubertz, J. Dilworth-Bart, Peter S. Hovmand, R. Prather, Maureen Swanson, Robin C. Puett, Ellis Ballard, Devon Payne-Sturges, K. Ellickson, Stephen B. Thomas, G. Huerta-Montanez, Deborah A. Cory-Slechta, N. Obot Witherspoon, R. Hammond

Publikováno v: ISEE Conference Abstracts. 2020

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79890c65b85129caa1ce8abdf32d1295
https://doi.org/10.1289/isee.2020.virtual.p-0692

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cAbl Kinase Regulates Inflammasome Activation and Pyroptosis via ASC Phosphorylation

Autor: Alex D. Vompe, Evan R. Prather, Mikhail A. Gavrilin, Mark D. Wewers, Christian C. McAndrew

Publikováno v: J Immunol

Inflammasome activation is regulated in part by the posttranslational modification of inflammasome proteins. Tyrosine phosphorylation is one possible modification. Having previously shown that the protein tyrosine kinase (PTK) inhibitor AG126 greatly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b4bab85298bcb9865633a32a9863f9
https://pubmed.ncbi.nlm.nih.gov/33568399

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Pleural Effusion Levels of Inflammasome Related Proteins in Exudates Compared to Transudates

Autor: Evan R. Prather, R. Story, Mark D. Wewers, Mikhail A. Gavrilin

Publikováno v: D70. REVISITING LUNG INFECTION AND INFLAMMATORY AXES.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84ef43d4217c233911d1096f0d5496b6
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7440

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Akademický článek

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Akademický článek

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DISULFIRAM EXERTS DOSE-DEPENDENT ACTIVATING AND INHIBITORY EFFECTS ON THE HUMAN INFLAMMASOME

Autor: Evan R. Prather, Gregory Eisinger, Elliott D. Crouser, Mark D. Wewers, Wissam Osman, Mikhail A. Gavrilin

Publikováno v: Chest. 160:A1083

TOPIC: Critical Care TYPE: Original Investigations PURPOSE: Gasdermin-D (GSDMD) is a pore-forming molecule that serves as the final effector of pyroptosis (a form of inflammatory cell death) following activation of the cellular inflammasome in monocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::063d81be09003dc33e978fcdbcb2f825
https://doi.org/10.1016/j.chest.2021.07.1001

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Elektronická kniha

Immigrating to America

Autor: Michelle R. Prather

This engaging primary source book dives into history to explore immigration during the twentieth century. Learn about the journey millions of immigrants faced trying to seek freedom and better lives in the United States. These people helped shape the

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