Zobrazeno 1 - 10
of 175
pro vyhledávání: '"R. Poh"'
Autor:
Surein Arulananda, Megan O’Brien, Marco Evangelista, Laura J. Jenkins, Ashleigh R. Poh, Marzena Walkiewicz, Trishe Leong, John M. Mariadason, Jonathan Cebon, Srividya B. Balachander, Justin R. Cidado, Erinna F. Lee, Thomas John, Walter D. Fairlie
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Recently, we showed that drugs targeting the BCL-2-regulated apoptosis pathway could kill MPM cell lines in vitro,
Externí odkaz:
https://doaj.org/article/ad883c64d8a746e29bfa7c2330196e64
Autor:
Moritz F. Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R. Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D. Huntington, Margaret L. Hibbs, Alex Boussioutas, Michele A. Grimbaldeston, Michael Buchert, Robert J. J. O’Donoghue, Frederick Masson, Matthias Ernst
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumor
Externí odkaz:
https://doaj.org/article/358dfe59c0ac41659d29059d99a2f0be
Autor:
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 4, Pp 1-15 (2019)
Abstract Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression. Here, we established the in vivo utility of bazedoxifene, a ster
Externí odkaz:
https://doaj.org/article/f3ddb855617e4e378193d6b8beddb2bb
Autor:
Surein Arulananda, Megan O’Brien, Marco Evangelista, Tiffany J. Harris, Nikita S. Steinohrt, Laura J. Jenkins, Marzena Walkiewicz, Robert J. J. O’Donoghue, Ashleigh R. Poh, Bibhusal Thapa, David S. Williams, Trishe Leong, John M. Mariadason, Xia Li, Jonathan Cebon, Erinna F. Lee, Thomas John, W. Douglas Fairlie
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/768c48b448e544079fe397dafe8d4bf3
Autor:
Ashleigh R. Poh, Matthias Ernst
Publikováno v:
Oncogene.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a 5-year survival rate of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d8014fd0698c9beb71ad197bf7b1e7
https://doi.org/10.1038/s41388-023-02701-x
https://doi.org/10.1038/s41388-023-02701-x
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Increased HCK activity in BMDMs supports tumor cell invasion in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0176964ef16bdad891da122661b61
https://doi.org/10.1158/2326-6066.22542897.v1
https://doi.org/10.1158/2326-6066.22542897.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Persistent activation of the latent transcription factor STAT3 is observed in gastric tumor epithelial and immune cells and is associated with a poor patient prognosis. Although targeting STAT3-activating upstream kinases offers therapeutically viabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a55fcba6c2fa63a18d36a4da65f2571
https://doi.org/10.1158/2326-6066.c.6550074.v1
https://doi.org/10.1158/2326-6066.c.6550074.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Constitutive HCK activity in bone marrow-derived cells enhances STAT3 activation in tumors and tumor-associated macrophages.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a74ec4c16f52870e618866ba0774ef
https://doi.org/10.1158/2326-6066.22542900.v1
https://doi.org/10.1158/2326-6066.22542900.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Increased expression of genes associated with alternative macrophage polarization confers a poorer overall survival in human intestinal-type gastric cancer patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c074531e7422bd9f135060ddedca8ae
https://doi.org/10.1158/2326-6066.22542894
https://doi.org/10.1158/2326-6066.22542894
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3304b5be5c819c04cdad4eb8b5df768
https://doi.org/10.1158/2326-6066.22542888
https://doi.org/10.1158/2326-6066.22542888