Zobrazeno 1 - 10
of 340
pro vyhledávání: '"R. Pepper"'
Autor:
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F. Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R. Pepper, Leticia P. Roma, Emmanuel Ampofo, Wen-hong Li, Patrick E. MacDonald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however the underlying mechanisms remain unclear. Here we show, in β-cells from overweight humans without diabetes and mice fed a high-fat diet for 2 days, i
Externí odkaz:
https://doaj.org/article/5a3f165b1bd14fb4a4ae1864a4618c3e
Publikováno v:
Transplant International, Vol 37 (2024)
Externí odkaz:
https://doaj.org/article/968a0ab11ed742e39306c5c05fa9cd18
Autor:
Purushothaman Kuppan, Jordan Wong, Sandra Kelly, Jiaxin Lin, Jessica Worton, Chelsea Castro, Joy Paramor, Karen Seeberger, Nerea Cuesta-Gomez, Colin C. Anderson, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2201 (2023)
One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) micropart
Externí odkaz:
https://doaj.org/article/16b9bbccce744ae580602897ab1613e8
Autor:
Kateryna Polishevska, Sandra Kelly, Purushothaman Kuppan, Karen L. Seeberger, Saloni Aggarwal, Joy Paramor, Larry D. Unsworth, Hubert M. Tse, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1137 (2023)
Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration. Encapsulat
Externí odkaz:
https://doaj.org/article/66a636e3137441e39325b8f3f61481b3
Autor:
Purushothaman Kuppan, Sandra Kelly, Karen Seeberger, Chelsea Castro, Mandy Rosko, Andrew R. Pepper, Gregory S. Korbutt
Publikováno v:
Polymers, Vol 14, Iss 6, p 1120 (2022)
The subcutaneous space is currently being pursued as an alternative transplant site for ß-cell replacement therapies due to its retrievability, minimally invasive procedure and potential for graft imaging. However, implantation of ß-cells into an u
Externí odkaz:
https://doaj.org/article/778e324b93664d6dbe777656522524c0
Autor:
Andrew R. Pepper, Rena Pawlick, Antonio Bruni, John Wink, Yasmin Rafiei, Doug O’Gorman, Richard Yan-Do, Boris Gala-Lopez, Tatsuya Kin, Patrick E. MacDonald, A.M. James Shapiro
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1689-1700 (2017)
Beta-cell replacement therapy is an effective means to restore glucose homeostasis in select humans with autoimmune diabetes. The scarcity of “healthy” human donor pancreata restricts the broader application of this effective curative therapy.
Externí odkaz:
https://doaj.org/article/7a2e5616b5f345c8894e6551fb96b290
Autor:
Anissa Gamble, Rena Pawlick, Andrew R Pepper, Antonio Bruni, Adetola Adesida, Peter A Senior, Gregory S Korbutt, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206449 (2018)
Islet transplantation is an established clinical procedure for select patients with type 1 diabetes and severe hypoglycemia to stabilize glycemic control. Post-transplant, substantial beta cell mass is lost, necessitating multiple donors to maintain
Externí odkaz:
https://doaj.org/article/3a3360ee0b3d4303b0fba7d6b04000b4
Akademický článek
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Autor:
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiaoqing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia P Roma, Emmanuel Ampofo, Wen-hong Li, Patrick E MacDonald
Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however the underlying mechanisms remain unclear. In β-cells from overweight humans without diabetes, and mice fed a high-fat diet for 2 days, insulin exocytosis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e23302a82d7868d1680c9f64d82029
https://doi.org/10.1101/2022.04.05.487203
https://doi.org/10.1101/2022.04.05.487203
Autor:
Kateryna Polishevska, Osmanmyrat Hojanepesov, Purushothaman Kuppan, Sandra E. Kelly, Gregory S. Korbutt, Karen L. Seeberger, Andrew R. Pepper
Publikováno v:
American Journal of Transplantation. 20:714-725
The broad application of s cell transplantation for type 1 diabetes is hindered by the requisite of lifelong systemic immunosuppression. This study examines the utility of localized islet graft drug delivery to subvert the inflammatory and adaptive i