Zobrazeno 1 - 10
of 524
pro vyhledávání: '"R. Pearl"'
Autor:
Douglas Bradburn, Christopher R. Pearl
The'Critical Period'of American history—the years between the end of the American Revolution in 1783 and the ratification of the U.S. Constitution in 1789—was either the best of times or the worst of times. While some historians have celebrated t
Autor:
Christopher R. Pearl
Conceived in Crisis argues that the American Revolution was not just the product of the Imperial Crisis, brought on by Parliament's attempt to impose a new idea of empire on the American colonies. To an equal or greater degree, it was a response to t
Autor:
Seth A Ament, Jocelynn R Pearl, Jeffrey P Cantle, Robert M Bragg, Peter J Skene, Sydney R Coffey, Dani E Bergey, Vanessa C Wheeler, Marcy E MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, Nathan D Price
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 3, Pp 1-16 (2018)
Abstract Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcri
Externí odkaz:
https://doaj.org/article/37a0a3de07ca4d86ab89638ff4d313a8
Akademický článek
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Akademický článek
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Autor:
Helen Aguiar, Christopher Michael Jones, Luiz Alexandre Sacorague, Bin Dai, Megan R. Pearl, Alexandre Vieira, Ralph Piazza
Publikováno v:
Petrophysics – The SPWLA Journal of Formation Evaluation and Reservoir Description. 62:65-72
Three questions must be answered to optimize any openhole sampling program. These questions are where to sample, when to sample, and how to sample. Samples must be acquired from the right locations in order to answer the critical questions posed by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d45b829773546faab4a2e9180b0f50
https://doi.org/10.30632/pjv62n1-2021a4
https://doi.org/10.30632/pjv62n1-2021a4
Autor:
Matthew S. Wilken, Florian Busch, Zibo Chen, Ryan Kibler, Galen Dods, Vicki H. Wysocki, Christie Ciarlo, Mengxuan Jia, Hanna Liao, Michael C. Jewett, John A. Stamatoyannopoulos, Jocelynn R. Pearl, Basile I. M. Wicky, Shon Green, David Baker, Zachary L. VanAernum, Hana El-Samad, Scott E. Boyken, Andrew Hunt
Publikováno v:
Science
Designer gates Signaling in cells can occur through protein-protein interactions. Chen et al. describe the design of logic gates that can regulate protein association. The gates were built from small, designed proteins that all have a similar structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8ef1f35b344f8981120798e53c38a6
https://doi.org/10.1126/science.aay2790
https://doi.org/10.1126/science.aay2790
Autor:
Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao
Publikováno v:
Nature Medicine. 25:1131-1142
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19307c1ae395108f0cf1b74fb590fb6
https://doi.org/10.1038/s41591-019-0478-3
https://doi.org/10.1038/s41591-019-0478-3
Declarations of Independence : Indigenous Resilience, Colonial Rivalries, and the Cost of Revolution
Autor:
Christopher R. Pearl
How Indigenous Americans and colonial settlers negotiated the meaning of independence in the Revolutionary era On July 4, 1776, two hundred miles northwest of Philadelphia, on Indigenous land along the West Branch of the Susquehanna River, a group of