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Akademický článek

Classifying and quantifying changes in papilloedema using machine learning

Autor: Mark J Kupersmith, Louis R Pasquale, Randy Kardon, Tobias Elze, Joseph Branco, Jui-Kai Wang, Mona K Garvin, Brian Woods, David Szanto

Publikováno v: BMJ Neurology Open, Vol 6, Iss 1 (2024)

Background Machine learning (ML) can differentiate papilloedema from normal optic discs using fundus photos. Currently, papilloedema severity is assessed using the descriptive, ordinal Frisén scale. We hypothesise that ML can quantify papilloedema a

Externí odkaz: https://doaj.org/article/b9a54ce069a2461cbd7553f5d55c5cee

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Akademický článek

Association between Diabetes and Exfoliation Syndrome

Autor: Megan Yu, BS, Hannah H. Hwang, BS, Janey L. Wiggs, MD, PhD, Louis R. Pasquale, MD, Jae H. Kang, ScD

Publikováno v: Ophthalmology Science, Vol 4, Iss 3, Pp 100436- (2024)

Topic: This systematic review and meta-analysis summarizes the existing evidence for the association of diabetes mellitus (DM) and exfoliation syndrome (XFS). Clinical Relevance: Understanding and quantifying these associations may aid clinical guide

Externí odkaz: https://doaj.org/article/1fb000f1b63447b488bdfa7c5a35b4b5

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Akademický článek

Generative Artificial Intelligence Through ChatGPT and Other Large Language Models in Ophthalmology

Autor: Ting Fang Tan, MBBS, Arun James Thirunavukarasu, BA MB, BChir (Cantab), J. Peter Campbell, MD, MPH, Pearse A. Keane, MD, FRCOphth, Louis R. Pasquale, MD, FARVO, Michael D. Abramoff, MD, PhD, Jayashree Kalpathy-Cramer, PhD, Flora Lum, MD, Judy E. Kim, MD, FARVO, Sally L. Baxter, MD, MSc, Daniel Shu Wei Ting, MD, PhD

Publikováno v: Ophthalmology Science, Vol 3, Iss 4, Pp 100394- (2023)

The rapid progress of large language models (LLMs) driving generative artificial intelligence applications heralds the potential of opportunities in health care. We conducted a review up to April 2023 on Google Scholar, Embase, MEDLINE, and Scopus us

Externí odkaz: https://doaj.org/article/b1a869c7ddda477ea610000e433132d7

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Akademický článek

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Autor: Oana A. Zeleznik, Jae H. Kang, Jessica Lasky-Su, A. Heather Eliassen, Lisa Frueh, Clary B. Clish, Bernard A. Rosner, Tobias Elze, Pirro Hysi, Anthony Khawaja, Janey L. Wiggs, Louis R. Pasquale, UK Biobank Eye and Vision Consortium

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma is the most common form, and yet the etiology of this multifactorial disease is poorly understood. We aimed to id

Externí odkaz: https://doaj.org/article/036821c4b5e24ab5a64ae72665362fa8

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Akademický článek

Association between Heat Shock Protein-Specific T-Cell Counts and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma

Autor: Chhavi Saini, MD, Shuhong Jiang, MD, PhD, Julia Devlin, BS, Li Pan, PhD, Yizhen Tang, MD, PhD, Jing Tang, MD, PhD, Jessica A. Sun, BA, Maltish M. Lorenzo, MD, Qingyi Wang, MD, Louis R. Pasquale, MD, Kin-Sang Cho, PhD, Dong Feng Chen, MD, PhD, Lucy Q. Shen, MD

Publikováno v: Ophthalmology Science, Vol 3, Iss 3, Pp 100310- (2023)

Objective: Previous laboratory reports implicate heat shock protein (HSP)–specific T-cell responses in glaucoma pathogenesis; here, we aimed to provide direct clinical evidence by correlating systemic HSP-specific T-cell levels with glaucoma severi

Externí odkaz: https://doaj.org/article/741722948f694731b0e08bf81c1bc6ea

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Akademický článek

Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disordersResearch in context

Autor: Santiago Diaz-Torres, Weixiong He, Jackson Thorp, Sahba Seddighi, Sean Mullany, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Anthony P. Khawaja, Alex W. Hewitt, Jamie E. Craig, David A. Mackey, Janey L. Wiggs, Cornelia van Duijn, Michelle K. Lupton, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani

Publikováno v: EBioMedicine, Vol 92, Iss , Pp 104615- (2023)

Summary: Background: Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by progressive degeneration of the optic nerve that leads to irreversible visual impairment. Multiple epidemiological studies suggest an association between

Externí odkaz: https://doaj.org/article/998bca0455cc4d5c8fd546e1ecf16ea5

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Akademický článek

Archetypal analysis of longitudinal visual fields for idiopathic intracranial hypertension patients presenting in a clinic setting.

Autor: Joseph Branco, Tobias Elze, Jui-Kai Wang, Louis R Pasquale, Mona K Garvin, Randy Kardon, Mark J Kupersmith

Publikováno v: PLOS Digital Health, Vol 2, Iss 5, p e0000240 (2023)

We previously applied archetypal analysis (AA) using visual fields (VF) from the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) to derive a model, which quantified patterns (or archetypes [ATs] of VF loss), anticipated recovery, and ide

Externí odkaz: https://doaj.org/article/d26479fe9e814a6ebd855bcaf9e39808

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