Zobrazeno 1 - 10
of 54
pro vyhledávání: '"R. Pannunzio"'
Autor:
Valeria Rangel, Jason N. Sterrenberg, Aya Garawi, Vyanka Mezcord, Melissa L. Folkerts, Sabrina E. Calderon, Yadhira E. Garcia, Jinglong Wang, Eli M. Soyfer, Oliver S. Eng, Jennifer B. Valerin, Sora Park Tanjasiri, Fabiola Quintero-Rivera, Marcus M. Seldin, Selma Masri, Richard L. Frock, Angela G. Fleischman, Nicholas R. Pannunzio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Activation-induced cytidine deaminase (AID) is a B cell-specific mutator required for antibody diversification. However, it is also implicated in the etiology of several B cell malignancies. Evaluating the AID-induced mutation load in patien
Externí odkaz:
https://doaj.org/article/7199da5c9dc04e879f3964f64ebafee3
Autor:
Jessica L. Kelliher, Melissa L. Folkerts, Kaiyuan V. Shen, Wan Song, Kyle Tengler, Clara M. Stiefel, Seong-Ok Lee, Eloise Dray, Weixing Zhao, Brian Koss, Nicholas R. Pannunzio, Justin W. Leung
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The master DNA damage repair histone protein, H2AX, is essential for orchestrating the recruitment of downstream mediator and effector proteins at damaged chromatin. The phosphorylation of H2AX at S139, γH2AX, is well-studied for its DNA re
Externí odkaz:
https://doaj.org/article/f40958dd8a9b496c9a1c7b226404941a
Publikováno v:
F1000Research, Vol 12 (2023)
In modern society, there is a growing population affected by circadian clock disruption through night shift work, artificial light-at-night exposure, and erratic eating patterns. Concurrently, the rate of cancer incidence in individuals under the age
Externí odkaz:
https://doaj.org/article/46483db7248944148d8e1af2296c46c3
Autor:
Jason N. Sterrenberg, Melissa L. Folkerts, Valeria Rangel, Sarah Eugenie Lee, Nicholas R. Pannunzio
Publikováno v:
Trends in cancer, vol 8, iss 4
Trends Cancer
Trends Cancer
Chromosomal translocations arising from aberrant repair of multiple DNA double-strand breaks (DSBs) are a defining characteristic of many cancers. DSBs are an essential part of physiological processes in antibody-producing B cells. The B cell environ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c439302d4f807cd9d1649e68abd73f99
https://doi.org/10.1016/j.trecan.2022.01.003
https://doi.org/10.1016/j.trecan.2022.01.003
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1025-1031 (2016)
Summary: The interplay of transcription, topological tension, and chromosome breakage is a subject of intense interest, but, with so many facets to the problem, it is difficult to test. Here, we vary the orientation of promoters relative to one anoth
Externí odkaz:
https://doaj.org/article/c4acdcde996b46239c286bfd5a5ece3a
Autor:
Sung Kook Chun, Bridget M. Fortin, Rachel C. Fellows, Amber N. Habowski, Amandine Verlande, Wei A. Song, Alisa L. Mahieu, Austin E. Y. T. Lefebvre, Jason N. Sterrenberg, Leandro M. Velez, Michelle A. Digman, Robert A. Edwards, Nicholas R. Pannunzio, Marcus M. Seldin, Marian L. Waterman, Selma Masri
Publikováno v:
Science Advances. 8
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of young onset CRC include environmental aspects, such as lifestyle and dietary factors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ec55e87ef84c7b845672afa28704f48
https://doi.org/10.1126/sciadv.abo2389
https://doi.org/10.1126/sciadv.abo2389
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 557-569 (2014)
R loops exist at the murine IgH switch regions and possibly other locations, but their functional importance is unclear. In biochemical systems, R loop initiation requires DNA sequence regions containing clusters of G nucleotides, but cellular studie
Externí odkaz:
https://doaj.org/article/8325885ccd534711aaa18a134a04e9b2
Publikováno v:
F1000Research. 12:116
In modern society, there is a growing population affected by circadian clock disruption through night shift work, artificial light-at-night exposure, and erratic eating patterns. Concurrently, the rate of cancer incidence in individuals under the age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cb3ea3ea1412b25d788b2c427e5558
https://doi.org/10.12688/f1000research.128716.2
https://doi.org/10.12688/f1000research.128716.2
Publikováno v:
Journal of Biological Chemistry. 293:10512-10523
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB) repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of the S and G(2) phases. NHEJ relies on Ku to thread onto DNA termini and there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62783021d681946a70dd572bd846c49d
https://doi.org/10.1074/jbc.tm117.000374
https://doi.org/10.1074/jbc.tm117.000374
Publikováno v:
Trends in Biochemical Sciences. 43:490-498
A subset of chromosomal translocations related to B cell malignancy in human patients arises due to DNA breaks occurring within defined 20-600 base pair (bp) zones. Several factors influence the breakage rate at these sites including transcription, D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee6632dbcfada450fc537eb089ec57a
https://doi.org/10.1016/j.tibs.2018.04.004
https://doi.org/10.1016/j.tibs.2018.04.004