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RNA-binding proteins: Underestimated contributors in tumorigenesis

Autor: Y. Zhao, C. Mir, Y. Garcia-Mayea, R. Paciucci, H. Kondoh, M.E. LLeonart

Publikováno v: Seminars in Cancer Biology. 86:431-444

mRNA export, translation, splicing, cleavage or capping determine mRNA stability, which represents one of the primary aspects regulating gene expression and function. RNA-binding proteins (RBPs) bind to their target mRNAs to regulate multiple cell fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b34bbbb047d2428a8cf9649c826f439
https://doi.org/10.1016/j.semcancer.2022.01.010

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PO-049 Quantitative proteomics unveils key mitotic regulators involved in the transition to androgen independent prostate cancer

Autor: J. Morote, M. Olivan, Antonio Gil-Moreno, R. Paciucci, Eduard Sabidó, N. Masia, Eva Borràs, A. Santamaria

Publikováno v: ESMO Open. 3:A39-A40

Introduction Prostate cancer (PCa) is the most commonly diagnosed invasive malignancy and the second leading cause of cancer-related deaths among men. Androgens are crucial for the initiation and progression of PCa and thus, androgen deprivation ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd457bd3cf1a4571d3ee92ced6e2dbae
https://doi.org/10.1136/esmoopen-2018-eacr25.93

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Role of 300 kDa complexes as intermediates in tubulin folding and dimerization: characterization of a 25 kDa cytosolic protein involved in the GTP-dependent release of monomeric tubulin

Autor: R Paciucci

Publikováno v: Biochemical Journal. 301:105-110

beta-Tubulin synthesized in vitro in rabbit reticulocyte lysate is found associated with 900 kDa complexes (C900) containing T Complex Polypeptide 1 (TCP1), heat-shock protein (hsp) 70 and other unidentified proteins, with smaller 300 kDa complexes (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bc71704e2ae300e8b3b63911ebac6a
https://doi.org/10.1042/bj3010105

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Incorporation of tubulin subunits into dimers requires GTP hydrolysis

Autor: A, Fontalba, R, Paciucci, J, Avila, J C, Zabala

Publikováno v: Journal of Cell Science. 106:627-632

A toroid multisubunit complex of 800–900 kDa has been implicated in assisting protein folding of at least two cytoplasmic proteins, actin and tubulin. This process is dependent on the presence of magnesium ions and ATP hydrolysis. In vitro translat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56699cf13855e04ee1cc040b8494fdff
https://doi.org/10.1242/jcs.106.2.627

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Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element

Autor: Angel Pellicer, R Paciucci

Publikováno v: Molecular and Cellular Biology. 11:1334-1343

The 5' flanking region of the mouse N-ras gene was investigated to determine the elements governing transcriptional activity of the gene. The promoter did not contain typical TATA or CCAAT boxes, and according to primer extension and RNase protection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14a714de066b39baa92121ccda82efd
https://doi.org/10.1128/mcb.11.3.1334

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Safety Features of Protective Equipment for Work in the Presence of High Temperatures and Methods for Testing their Efficiency

Autor: G. Magliacani, R. Paciucci

Publikováno v: The Management of Burns and Fire Disasters: Perspectives 2000 ISBN: 9789401066471

Risk is implicit in every kind of human activity and the probability of its occurrence and the gravity of the consequences depend on the type of activity involved.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9eb8c9fda93fe3c175569eff835eb599
https://doi.org/10.1007/978-94-009-0361-6_95

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Binding of heat-shock protein 70 (hsp70) to tubulin

Autor: C. Sanchez, R. Padilla, R. Paciucci, Jesús Avila, Juan Carlos Zabala

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Binding of heat-shock protein (hsp70) to polymerized tubulin has been investigated by in vitro experiments. The tubulin region involved in binding to hsp70 corresponds to the carboxy-terminal residues 431-444, also involved in the association with ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c6438d9aebbb923da3bb03d7591af8
http://hdl.handle.net/10261/251961

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