Zobrazeno 1 - 10
of 20
pro vyhledávání: '"R. P. Weitzel"'
Autor:
Naoya Uchida, R Patrick Weitzel, Anna Shvygin, Luke P Skala, Lydia Raines, Aylin C Bonifacino, Allen E Krouse, Mark E Metzger, Robert E Donahue, John F Tisdale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Reduced intensity conditioning (RIC) is desirable for hematopoietic stem cell (HSC) gene therapy applications. However, low gene marking was previously observed in gene therapy trials, suggesting that RIC might be insufficient for (i) opening niches
Externí odkaz:
https://doaj.org/article/b2866a0cb9114dddbfe8675ea28d0e4a
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67189 (2013)
Non-Fc-binding Anti CD3 antibody has proven successful in reverting diabetes in the non-obese diabetes mouse model of type 1 diabetes and limited efficacy has been observed in human clinical trials. We hypothesized that addition of rapamycin, an mTOR
Externí odkaz:
https://doaj.org/article/470e357e8eee443d894e89877c3017e0
Autor:
M M Hsieh, Allen E. Krouse, Mark E. Metzger, Molly E. Evans, John F. Tisdale, R P Weitzel, Naoya Uchida, R Green, Robert E. Donahue, Aylin C. Bonifacino
Publikováno v:
Gene Therapy. 21:148-157
Reduced intensity conditioning (RIC) is desirable for hematopoietic stem cell (HSC) targeted gene therapy; however, RIC may be insufficient for efficient engraftment and inducing immunological tolerance to transgenes. We previously established long-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ad1a34339e270767bab09764a7c219
https://doi.org/10.1038/gt.2013.67
https://doi.org/10.1038/gt.2013.67
Autor:
Oswald Phang, M M Hsieh, R. P. Weitzel, Jonathan D. Powell, Leo Luznik, C Madison, Courtney D. Fitzhugh, John F. Tisdale
Publikováno v:
Bone Marrow Transplantation. 48:1335-1341
Because of the toxicity associated with myeloablative conditioning, nonmyeloablative regimens are increasingly being used in vulnerable patient populations. For patients with sickle cell disease, stable mixed chimerism has proven sufficient to revers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717059f185041adccbef94a84370728b
https://doi.org/10.1038/bmt.2013.60
https://doi.org/10.1038/bmt.2013.60
Publikováno v:
Leukemia. 25:169-172
Reduced methyl-CpG protein binding contributing to miR-184 expression in umbilical cord blood CD4 + T-cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d7827110ce90e17c47fd581ba2fe4d
https://doi.org/10.1038/leu.2010.227
https://doi.org/10.1038/leu.2010.227
Autor:
Hillard M. Lazarus, Mathew Lesniewski, M. Kozik, Howard J. Meyerson, M Z Ratajczak, L.R. Fanning, Magdalena Tary-Lehmann, Phil Paul, Y. Hegerfeldt, Jaroslaw P. Maciejewski, Marcie R. Finney, R. P. Weitzel, Mary J. Laughlin
Publikováno v:
Leukemia. 22:1786-1790
Allogeneic transplantation of multiple umbilical cord blood units in adults: role of pretransplant-mixed lymphocyte reaction to predict host-vs-graft rejection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03799dbffa5a0d2c7193778588db923e
https://doi.org/10.1038/leu.2008.55
https://doi.org/10.1038/leu.2008.55
Addition of rapamycin to anti-CD3 antibody improves long-term glycaemia control in diabetic NOD mice
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67189 (2013)
PLoS ONE
PLoS ONE
Aims/Hypothesis Non-Fc-binding Anti CD3 antibody has proven successful in reverting diabetes in the non-obese diabetes mouse model of type 1 diabetes and limited efficacy has been observed in human clinical trials. We hypothesized that addition of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abccfa03e9122f1826f2db29a37254e9
http://europepmc.org/articles/PMC3691209?pdf=render
http://europepmc.org/articles/PMC3691209?pdf=render
Autor:
Peter Haviernik, Mary J. Laughlin, Nicholas J. Greco, Phil Paul, M Z Ratajczak, Suzanne Kadereit, Y. Hegerfeldt, L.R. Fanning, Yu-Chung Yang, Mathew Lesniewski, M. Kozik, J.P. Maciejewski, R. P. Weitzel, Marcie R. Finney
Publikováno v:
Leukemia. 22(12)
On activation, umbilical cord blood (UCB) CD4(+) T cells demonstrate reduced expression of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), whereas maintaining equivalent interleukin-2 (IL-2) levels, as compared with adult pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ab158fdc0948ace594d280886189a4
https://pubmed.ncbi.nlm.nih.gov/18769450
https://pubmed.ncbi.nlm.nih.gov/18769450
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::622dd37375783a5b29fe606ead22903a
https://doi.org/10.1096/fasebj.22.1_supplement.862.22
https://doi.org/10.1096/fasebj.22.1_supplement.862.22