The proteome of extracellular vesicles of the lung fluke Paragonimus kellicotti produced in vitro and in the lung cyst

Autor: Lucia S. Di Maggio, Kerstin Fischer, Devyn Yates, Kurt C. Curtis, Bruce A. Rosa, John Martin, Petra Erdmann-Gilmore, Robert S. W. Sprung, Makedonka Mitreva, R. Reid Townsend, Gary J. Weil, Peter U. Fischer

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Paragonimiasis is a zoonotic, food-borne trematode infection that affects 21 million people globally. Trematodes interact with their hosts via extracellular vesicles (EV) that carry protein and RNA cargo. We analyzed EV in excretory-secretor

Externí odkaz: https://doaj.org/article/ad1736ee439c48df8c879adcd35181d2

Comparative proteomics of adult Paragonimus kellicotti excretion/secretion products released in vitro or present in the lung cyst nodule.

Autor: Lucia S Di Maggio, Kurt C Curtis, Petra Erdmann-Gilmore, Robert S W Sprung, R Reid Townsend, Gary J Weil, Peter U Fischer

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010679 (2022)

Paragonimus kellicotti is a zoonotic lung fluke infection, the agent of North American paragonimiasis, and an excellent model for other Paragonimus infections. The excretory/secretory proteins (ESP) released by parasites and presented at the parasite

Externí odkaz: https://doaj.org/article/461c3f8cf07042459b6ad539f46a7b37

Effect of Framework Charge Density on the Ion Exchange Properties of Zeolites

Autor: R. P. Townsend, K. R. Franklin, J. F. O'Connor

Publikováno v: Adsorption Science & Technology, Vol 1 (1984)

Members of a group of zeolites such as X and Y differ from each other only in the degree to which aluminium has isomorphously replaced silicon within the framework. As far as ion exchange properties are concerned, the effects of isomorphously increas

Externí odkaz: https://doaj.org/article/165d1e69526245cbba28dc791e87fb1d

Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

Autor: Yingwei Hu, Jianbo Pan, Punit Shah, Minghui Ao, Stefani N. Thomas, Yang Liu, Lijun Chen, Michael Schnaubelt, David J. Clark, Henry Rodriguez, Emily S. Boja, Tara Hiltke, Christopher R. Kinsinger, Karin D. Rodland, Qing Kay Li, Jiang Qian, Zhen Zhang, Daniel W. Chan, Hui Zhang, Akhilesh Pandey, Amanda Paulovich, Andrew Hoofnagle, Bing Zhang, D.R. Mani, Daniel C. Liebler, David F. Ransohoff, David Fenyo, David L. Tabb, Douglas A. Levine, Eric Kuhn, Forest M. White, Gordon A. Whiteley, Heng Zhu, Ie-Ming Shih, Jasmin Bavarva, Jason E. McDermott, Jeffrey Whiteaker, Karen A. Ketchum, Karl R. Clauser, Kelly Ruggles, Kimberly Elburn, Li Ding, Linda Hannick, Lisa J. Zimmerman, Mark Watson, Mathangi Thiagarajan, Matthew J.C. Ellis, Mauricio Oberti, Mehdi Mesri, Melinda E. Sanders, Melissa Borucki, Michael A. Gillette, Michael Snyder, Nathan J. Edwards, Negin Vatanian, Paul A. Rudnick, Peter B. McGarvey, Philip Mertins, R. Reid Townsend, Ratna R. Thangudu, Richard D. Smith, Robert C. Rivers, Robert J.C. Slebos, Samuel H. Payne, Sherri R. Davies, Shuang Cai, Stephen E. Stein, Steven A. Carr, Steven J. Skates, Subha Madhavan, Tao Liu, Xian Chen, Yingming Zhao, Yue Wang, Zhiao Shi

Publikováno v: Cell Reports, Vol 33, Iss 3, Pp 108276- (2020)

Summary: Many gene products exhibit great structural heterogeneity because of an array of modifications. These modifications are not directly encoded in the genomic template but often affect the functionality of proteins. Protein glycosylation plays

Externí odkaz: https://doaj.org/article/687878b78b8f4a70bfe6276db55dbef8

Maternal obese-type gut microbiota differentially impact cognition, anxiety and compulsive behavior in male and female offspring in mice.

Autor: Annadora J Bruce-Keller, Sun-Ok Fernandez-Kim, R Leigh Townsend, Claudia Kruger, Richard Carmouche, Susan Newman, J Michael Salbaum, Hans-Rudolf Berthoud

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175577 (2017)

Maternal obesity is known to predispose offspring to metabolic and neurodevelopmental abnormalities. While the mechanisms underlying these phenomena are unclear, high fat diets dramatically alter intestinal microbiota, and gut microbiota can impact p

Externí odkaz: https://doaj.org/article/d5f721e497504a7aaf3a439def1b7231