Zobrazeno 1 - 10
of 486
pro vyhledávání: '"R. P. Townsend"'
Autor:
Lucia S. Di Maggio, Kerstin Fischer, Devyn Yates, Kurt C. Curtis, Bruce A. Rosa, John Martin, Petra Erdmann-Gilmore, Robert S. W. Sprung, Makedonka Mitreva, R. Reid Townsend, Gary J. Weil, Peter U. Fischer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Paragonimiasis is a zoonotic, food-borne trematode infection that affects 21 million people globally. Trematodes interact with their hosts via extracellular vesicles (EV) that carry protein and RNA cargo. We analyzed EV in excretory-secretor
Externí odkaz:
https://doaj.org/article/ad1736ee439c48df8c879adcd35181d2
Autor:
Devyn Yates, Lucia S. Di Maggio, Bruce A. Rosa, Robert W. Sprung, Petra Erdmann-Gilmore, R. Reid Townsend, Philip J. Budge, Joseph Kamgno, Makedonka Mitreva, Gary J. Weil, Peter U. Fischer
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
BackgroundImproved diagnostic tools are needed for detecting active filarial infections in humans. Tests are available that detect adult W. bancrofti circulating filarial antigen, but there are no sensitive and specific biomarker tests for brugian fi
Externí odkaz:
https://doaj.org/article/664a178a13a740d4ba347c475f01d58d
Autor:
Christine Hehnly, Aiqin Shi, Paddy Ssentongo, Lijun Zhang, Albert Isaacs, Sarah U. Morton, Nicholas Streck, Petra Erdmann-Gilmore, Igor Tolstoy, R. Reid Townsend, David D. Limbrick, Joseph N. Paulson, Jessica E. Ericson, Michael Y. Galperin, Steven J. Schiff, James R. Broach
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low- and middle-income countries. Hydrocephalus preceded by an infection, or postinfectious hydrocephalus, accounts for up to 60% of hyd
Externí odkaz:
https://doaj.org/article/4ed3d517da8341ba9e490b66a1529316
Autor:
Lucia S Di Maggio, Kurt C Curtis, Petra Erdmann-Gilmore, Robert S W Sprung, R Reid Townsend, Gary J Weil, Peter U Fischer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010679 (2022)
Paragonimus kellicotti is a zoonotic lung fluke infection, the agent of North American paragonimiasis, and an excellent model for other Paragonimus infections. The excretory/secretory proteins (ESP) released by parasites and presented at the parasite
Externí odkaz:
https://doaj.org/article/461c3f8cf07042459b6ad539f46a7b37
Autor:
Samuel C. Uzoechi, Bruce A. Rosa, Kumar Sachin Singh, Young-Jun Choi, Bethany K. Bracken, Paul J. Brindley, R. Reid Townsend, Robert Sprung, Bin Zhan, Maria-Elena Bottazzi, John M. Hawdon, Yide Wong, Alex Loukas, Sergej Djuranovic, Makedonka Mitreva
Publikováno v:
Pathogens, Vol 12, Iss 1, p 95 (2023)
The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm’s excretory/secretory products (ESPs), which have a wide spectrum of
Externí odkaz:
https://doaj.org/article/872958c697284fcca62caad1f1054a2b
Autor:
Brandon B. Boland, Michael B. Mumphrey, Zheng Hao, R. Leigh Townsend, Benji Gill, Stephanie Oldham, Sarah Will, Christopher D. Morrison, Sangho Yu, Heike Münzberg, Christopher J. Rhodes, James L. Trevaskis, Hans-Rudolf Berthoud
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 64-72 (2019)
Objective: Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity and metabolic disease. A
Externí odkaz:
https://doaj.org/article/f00f453e8c54473090de2a31207bdf75
Autor:
Justine Faramia, Zheng Hao, Michael B. Mumphrey, R. Leigh Townsend, Stéphanie Miard, Anne-Marie Carreau, Mélanie Nadeau, Frédérique Frisch, Elena-Dana Baraboi, Thomas Grenier-Larouche, Christophe Noll, Meng Li, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Stéfane Lebel, Christopher D. Morrison, Heike Münzberg, Denis Richard, André C. Carpentier, André Tchernof, Hans-Rudolf Berthoud, Frédéric Picard
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100248- (2021)
Summary: Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching hig
Externí odkaz:
https://doaj.org/article/317635759b854ab9b3c219568d105c04
Autor:
Albert M. Isaacs, Sarah U. Morton, Mercedeh Movassagh, Qiang Zhang, Christine Hehnly, Lijun Zhang, Diego M. Morales, Shamim A. Sinnar, Jessica E. Ericson, Edith Mbabazi-Kabachelor, Peter Ssenyonga, Justin Onen, Ronnie Mulondo, Mady Hornig, Benjamin C. Warf, James R. Broach, R. Reid Townsend, David D. Limbrick, Jr., Joseph N. Paulson, Steven J. Schiff
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102351- (2021)
Summary: Inflammation during neonatal brain infections leads to significant secondary sequelae such as hydrocephalus, which often follows neonatal sepsis in the developing world. In 100 African hydrocephalic infants we identified the biological pathw
Externí odkaz:
https://doaj.org/article/fe91a2ee504742a49bd7a725309d337a
Autor:
Yingwei Hu, Jianbo Pan, Punit Shah, Minghui Ao, Stefani N. Thomas, Yang Liu, Lijun Chen, Michael Schnaubelt, David J. Clark, Henry Rodriguez, Emily S. Boja, Tara Hiltke, Christopher R. Kinsinger, Karin D. Rodland, Qing Kay Li, Jiang Qian, Zhen Zhang, Daniel W. Chan, Hui Zhang, Akhilesh Pandey, Amanda Paulovich, Andrew Hoofnagle, Bing Zhang, D.R. Mani, Daniel C. Liebler, David F. Ransohoff, David Fenyo, David L. Tabb, Douglas A. Levine, Eric Kuhn, Forest M. White, Gordon A. Whiteley, Heng Zhu, Ie-Ming Shih, Jasmin Bavarva, Jason E. McDermott, Jeffrey Whiteaker, Karen A. Ketchum, Karl R. Clauser, Kelly Ruggles, Kimberly Elburn, Li Ding, Linda Hannick, Lisa J. Zimmerman, Mark Watson, Mathangi Thiagarajan, Matthew J.C. Ellis, Mauricio Oberti, Mehdi Mesri, Melinda E. Sanders, Melissa Borucki, Michael A. Gillette, Michael Snyder, Nathan J. Edwards, Negin Vatanian, Paul A. Rudnick, Peter B. McGarvey, Philip Mertins, R. Reid Townsend, Ratna R. Thangudu, Richard D. Smith, Robert C. Rivers, Robert J.C. Slebos, Samuel H. Payne, Sherri R. Davies, Shuang Cai, Stephen E. Stein, Steven A. Carr, Steven J. Skates, Subha Madhavan, Tao Liu, Xian Chen, Yingming Zhao, Yue Wang, Zhiao Shi
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108276- (2020)
Summary: Many gene products exhibit great structural heterogeneity because of an array of modifications. These modifications are not directly encoded in the genomic template but often affect the functionality of proteins. Protein glycosylation plays
Externí odkaz:
https://doaj.org/article/687878b78b8f4a70bfe6276db55dbef8