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DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein

Autor: Patrick Y.S. Lam, Y. Ru, Prabhakar K. Jadhav, M. M. Rayner, Beverly C. Cordova, P. E. Aldrich, R. P. Meade

Publikováno v: Antimicrobial Agents and Chemotherapy. 38:1635-1640

DMP 323, a C-2-symmetrical cyclic urea, is representative of a new class of inhibitors of human immunodeficiency virus protease. In this study, we correlate the potent antiviral activity of DMP 323 in acute infections with antiprotease activity asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b838d74848bdd1483597fde05045c87f
https://doi.org/10.1128/aac.38.7.1635

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Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis

Autor: P C, Wong, E J, Crain, R M, Knabb, R P, Meade, M L, Quan, C A, Watson, R R, Wexler, M R, Wright, A M, Slee

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(1)

SK549 (mol. wt. 546 Da) is a synthetic, selective inhibitor of human coagulation factor Xa (fXa) (K(i) = 0.52 nM). This study compared the antithrombotic effects of SK549 and a series of benzamidine isoxazoline fXa inhibitors with aspirin, DuP 714 (a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d21c21dc60923e6d38b235ab8a8c6e25
https://pubmed.ncbi.nlm.nih.gov/10991981

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Axonal spheroids in the cochlear nucleus of normal beagle dogs

Autor: C. A. Anderson, R. P. Meade, B. A. Summers, M. V. Slayter

Publikováno v: Veterinary pathology. 35(2)

In the course of drug evaluation studies, sporadic axonal spheroids were identified in the cochlear nucleus of 8–15-month-old Beagle dogs. These structures were identified by Bielschowski histochemical and anti-neurofilament immunohistochemical sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65a34dbf2ce4e56631895458ff414ac
https://pubmed.ncbi.nlm.nih.gov/9539371

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Effect of brefeldin A on alphaherpesvirus membrane protein glycosylation and virus egress

Autor: R P Meade, J. P. Card, Lynn W. Enquist, M. E. Whealy, A. K. Robbins

Publikováno v: Scopus-Elsevier

In this work we used brefeldin A (BFA), a specific inhibitor of export to the Golgi apparatus, to study pseudorabies virus viral glycoprotein processing and virus egress. BFA had little effect on initial synthesis and cotranslational modification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8433b4761204c99956559596e099ad8d
http://www.scopus.com/inward/record.url?eid=2-s2.0-0026083301&partnerID=MN8TOARS

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Pseudorabies virus infection of the rat central nervous system: ultrastructural characterization of viral replication, transport, and pathogenesis

Autor: RB Lynn, BH Lee, R. R. Miselis, Linda Rinaman, Lynn W. Enquist, J. P. Card, R P Meade

Publikováno v: Europe PubMed Central

Pseudorabies virus (PRV) has been used extensively to map synaptic circuits in the CNS and PNS. A fundamental assumption of these studies is that the virus replicates within synaptically linked populations of neurons and does not spread through the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7694f237e8f55eae1acacf0929256a1
http://europepmc.org/abstract/med/8388923

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