Zobrazeno 1 - 10
of 19
pro vyhledávání: '"R. P. Clement"'
Autor:
P. Bielefeld, A. Martirosyan, S. Martín-Suárez, A. Apresyan, G. F. Meerhoff, F. Pestana, S. Poovathingal, N. Reijner, W. Koning, R. A. Clement, I. Van der Veen, E. M. Toledo, O. Polzer, I. Durá, S. Hovhannisyan, B. S. Nilges, A. Bogdoll, N. D. Kashikar, P. J. Lucassen, T. G. Belgard, J. M. Encinas, M. G. Holt, C. P. Fitzsimons
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult hippocampus harbors neural stem cells (NSCs) that generate neu
Externí odkaz:
https://doaj.org/article/0c2fb42524ac4acfa68febab4842131e
Autor:
Vicent R. Poveda Clement
Publikováno v:
Revista de Cancioneros Impresos y Manuscritos, Iss 4, Pp 78-109 (2015)
Els stemmata codicum d’Amadeu Pagès i de Robert Archer ofereixen, com els autors mateixos preveien, resultats amb caràcter provisional i aproximat fins que no es revisen les relacions genealògiques de cadascun dels poemes i de cadascun dels can
Externí odkaz:
https://doaj.org/article/b99ef9c19ca94562bba572adc274bf94
Publikováno v:
Nonlinear Processes in Geophysics, Vol 14, Iss 3, Pp 257-271 (2007)
We report velocity and temperature spectra measured at nine levels from 1.42 meters up to 25.7 m over a smooth playa in Western Utah. Data are from highly convective conditions when the magnitude of the Obukhov length (our proxy for the depth of the
Externí odkaz:
https://doaj.org/article/15b5c476dbb144059fb8b1cc83d40853
Publikováno v:
Cancer research. 61(20)
P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many drugs, particularly cancer chemotherapeutics. Multidrug resistance (MDR) is caused largely by the efflux of therapeutics o
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(9)
The purpose of this study was to evaluate loratadine, desloratadine, and 3-OH-desloratadine as inhibitors of certain human liver cytochrome P-450 enzymes. Pooled human liver microsomes were used to determine whether loratadine, desloratadine, and 3-O
Publikováno v:
Pharmaceutical research. 18(6)
HMG-CoA reductase inhibitors (statins) are commonly prescribed for lipid lowering to treat hypercholesterolemia. Although they are well tolerated, their pharmacokinetic interactions with other drugs can lead to some adverse clinical consequences. The
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(8)
The absorption of many drugs is affected by their interaction with ATP-binding cassette (ABC) transporters. The most extensively studied of these ABC transporters is the proein product of MDR1 (multidrug resistance) that encodes a 170-kDa integral pl
Publikováno v:
Pharmaceutical research. 18(4)
The grapefruit juice component bergamottin is known to inactivate cytochrome P450 3A4, with grapefruit juice consumption causing increased absorption and enhanced oral bioavailability of many cytochrome P450 3A4 substrates. Many of these substrates a
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(6)
SCH 66712 [5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine] caused a time- and NADPH-dependent loss of CYP2D6 activity. The inactivation of human liver (HL) microsomal dextromethorphan O-demethylase activity, a prototype ma
Autor:
M B, Affrime, F, Cuss, D, Padhi, M, Wirth, S, Pai, R P, Clement, J, Lim, B, Kantesaria, K, Alton, M N, Cayen
Publikováno v:
Journal of clinical pharmacology. 40(11)
These studies were conducted to assess the systemic bioavailability of mometasone furoate (MF) administered by both the dry-powder inhaler (DPI) and the metered-dose inhaler with an alternate propellant (MDI-AP). The pharmacokinetics of single doses