Zobrazeno 1 - 10
of 30
pro vyhledávání: '"R. P. Castanho"'
Autor:
Marco Cavaco, Patrícia Fraga, Javier Valle, Ruben D. M. Silva, Lurdes Gano, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Blood–brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development relies on the e
Externí odkaz:
https://doaj.org/article/ff105247e7514a8eb2dac249aa0d9bfc
Autor:
Catarina I. P. Chaparro, Beatriz T. Simões, João P. Borges, Miguel A. R. B. Castanho, Paula I. P. Soares, Vera Neves
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2316 (2023)
Among central nervous system (CNS) disorders, Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and a major cause of dementia worldwide. The yet unclear etiology of AD and the high impenetrability of the blood–brain barrie
Externí odkaz:
https://doaj.org/article/70b9a80aca6e4f0595e916e875a7bbde
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1349-1358 (2021)
Abstract Proteolytic instability is a critical limitation for peptide‐based products. Although significant efforts are devoted to stabilize sequences against proteases/peptidases in plasma/serum, such approaches tend to be rather empirical, unspeci
Externí odkaz:
https://doaj.org/article/adbdf920d04f4465842e78b226334880
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The emergence of antimicrobial resistance (AMR) is rapidly increasing and it is one of the significant twenty-first century’s healthcare challenges. Unfortunately, the development of effective antimicrobial agents is a much slower and complex proce
Externí odkaz:
https://doaj.org/article/81479eace440483aacdfad70c106de57
Publikováno v:
Molecules, Vol 28, Iss 5, p 2283 (2023)
Cell viability and metabolic activity are ubiquitous parameters used in biochemistry, molecular biology, and biotechnological studies. Virtually all toxicology and pharmacological projects include at some point the evaluation of cell viability and/or
Externí odkaz:
https://doaj.org/article/408f9b43aefb4134be79e7fc0cc6a844
Publikováno v:
Life, Vol 13, Iss 4, p 887 (2023)
Inflammation is essential in the protection of the organism and wound repair, but in cases of chronic inflammation can also cause microvasculature deterioration. Thus, inflammation monitorization studies are important to test potential therapeutics.
Externí odkaz:
https://doaj.org/article/928a4d3b80c54ac8b1e77354b834889a
Publikováno v:
Frontiers in Medical Technology, Vol 3 (2021)
Externí odkaz:
https://doaj.org/article/dfbc6b56c2cf41c588824337605a1adb
Autor:
Christian Mink, Erik Strandberg, Parvesh Wadhwani, Manuel N. Melo, Johannes Reichert, Irene Wacker, Miguel A. R. B. Castanho, Anne S. Ulrich
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
BP100 is a short, designer-made membrane-active peptide with multiple functionalities: antimicrobial, cell-penetrating, and fusogenic. Consisting of five lysines and 6 hydrophobic residues, BP100 was shown to bind to lipid bilayers as an amphipathic
Externí odkaz:
https://doaj.org/article/de90319e98544420a3c6e113fcfc7d28
Autor:
Miguel de Almeida Fuzeta, Nuno Bernardes, Filipa D. Oliveira, Ana Catarina Costa, Ana Fernandes-Platzgummer, José Paulo Farinha, Carlos A. V. Rodrigues, Sunghoon Jung, Rong-Jeng Tseng, William Milligan, Brian Lee, Miguel A. R. B. Castanho, Diana Gaspar, Joaquim M. S. Cabral, Cláudia Lobato da Silva
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mesenchymal stromal cells (MSC) hold great promise for tissue engineering and cell-based therapies due to their multilineage differentiation potential and intrinsic immunomodulatory and trophic activities. Over the past years, increasing evidence has
Externí odkaz:
https://doaj.org/article/b500df7c63514a22843cbaa239e4e991
Autor:
Marco Cavaco, Clara Pérez-Peinado, Javier Valle, Rúben D. M. Silva, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These studies frequently depend on
Externí odkaz:
https://doaj.org/article/81a72c5e46694efeb31a6a682b0c2663