Zobrazeno 1 - 4
of 4
pro vyhledávání: '"R. P. Brueckner"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 24:213-223
Multiple doses of arteether (ARTE) at 25 mg/kg cause CNS and anorectic toxicities in rats. The same dose of ARTE was used to study the toxicokinetics (TK) after multiple injections and the pharmacokinetics (PK) following single administration. Animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f842570b5a9bf0ed9bfe580f907f1dd
https://doi.org/10.1007/bf03190023
https://doi.org/10.1007/bf03190023
Autor:
Margaret L. Pitt, R P Brueckner, Susan L. Welkos, Kelly J. Davis, J R Vaccaro, L C Battersby, Arthur M. Friedlander, William R. Byrne, J W Ezzell, G O Nelson
Publikováno v:
Scopus-Elsevier
A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience. Infection was induced by inhalation of aerosolized Yersin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab65589ddf1c141b6b82f2471016fab
https://doi.org/10.1128/aac.42.3.675
https://doi.org/10.1128/aac.42.3.675
Autor:
R P, Brueckner, L, Fleckenstein
Publikováno v:
Pharmaceutical research. 8(12)
Methemoglobin (MHb) formation can be a clinically significant and dose-limiting side effect of 8-aminoquinoline antimalarials. MHb may also protect against cyanide poisoning. A two-compartment pharmacokinetic model, linked to a sigmoid Emax pharmacod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::164d9f874569b11c255500c28c075330
https://pubmed.ncbi.nlm.nih.gov/1808614
https://pubmed.ncbi.nlm.nih.gov/1808614
Autor:
Michael A. Riel, R. K. Gordon, R. E. Clawson, G. E. Garcia, J. R. Haigh, C. R. Clark, R. P. Brueckner, D. E. Lenz
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:P87
Background RBC acetylcholinesterase (AChE) and serum butyrylcholinesterase (BChE) inhibition are considered good biomarkers for protection against exposure to nerve agents. These enzymes may be sequestered (reversibly bound) by pyridostigmine bromide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529d3733ea075790ced3b3cd74ab80ce
https://doi.org/10.1016/j.clpt.2003.11.332
https://doi.org/10.1016/j.clpt.2003.11.332