Zobrazeno 1 - 9
of 9
pro vyhledávání: '"R. Olavi Pelkonen"'
Publikováno v:
Acta Medica Scandinavica. 212:207-215
The hepatic injury developing during occupational exposure to chemicals was investigated in 23 male patients, aged 23–49 years, by comparing case histories, liver function tests, hepatic microsomal enzyme activities in vivo and in vitro with histol
Publikováno v:
Drugs. 25:113-120
The role of the liver on the kinetics of β-blockers metabolised by hepatic enzyme systems (propranolol) or eliminated unchanged (atenolol and sotalol) was investigated in 55 patients with diagnostic liver biopsy, who also required β-blockers for ca
Publikováno v:
European Journal of Clinical Investigation. 7:269-274
Drug metabolizing capacity was investigated in sixteen patients with cancer in the liver by comparing in vivo (antipyrine disappearance rate from plasma) and in vitro (cytochrome P-450, benzpyrene hydroxylase, and 7-ethoxycoumarin O-deethylase activi
Publikováno v:
Acta Endocrinologica. 104:S125-S129
Hepatic microsomal enzyme activity was investigated in 280 patients with diabetes mellitus. The oral antipyrine test was used as an in vivo index, and cytochrome P-450 content and arylhydrocarbon hydroxylase activity, determined from liver biopsies (
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 3:217-222
One hundred and twelve subjects were investigated to elucidate the influence of liver size on the relationship between in vivo (antipyrine kinetics) and in vitro (cytochrome P-450) studies of drug metabolism. The correlation between these variables a
Publikováno v:
Clinical pharmacology and therapeutics. 26(2)
The role of hepatic drug-metabolizing enzyme activity for plasma propranolol and sotalol levels was investigated in 68 patients with hypertension or angina pectoris by comparing elimination rate with antipyrine kinetics and cytochrome P-450 content i
Autor:
R. Olavi Pelkonen, Arno J. Arranto, Eero A. Sotaniemi, Sirkka Sutinen, Seppo Sutinen, Juhani Lehtola, Kyösti A. Sotaniemi
Publikováno v:
Acta medica Scandinavica. 214(3)
Three consecutive head nurses developed liver injury after years of handling cytostatic drugs. They had neurological symptoms associated with elevated serum alanine amino-transferase (ALAT) and alkaline phosphatase (ALP) levels. Liver histology showe
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Akademický článek
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