Zobrazeno 1 - 10
of 149
pro vyhledávání: '"R. Oftebro"'
Autor:
J. M. Dornish, B. Børretzen, Jahn M. Nesland, M. E. H. Juul, Erik O. Pettersen, Einar K. Rofstad, T. E. Aastveit, R. Oftebro, R. O. Larsen
Publikováno v:
British Journal of Cancer
The deuterated benzaldehyde derivative zilascorb(2H), 5,6-O-benzylidene-d-L-ascorbic acid, was administered once daily by i.v. injection in nude mice with grafted tumours of a human malignant melanoma (E.E.) and ovarian carcinoma (OVCAR-3) origins. L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda4efcfc1527c99604b0c486ff99438
https://doi.org/10.1038/bjc.1993.121
https://doi.org/10.1038/bjc.1993.121
Publikováno v:
ChemInform. 22
Methods are described for the syntheses of chloromethyl propargyl ethers and propargyl halides substituted with a hydroxyalkyl group, and their use in alkylation reactions of 2-pyrimidinones. The N-alkynyl derivatives are reversible inhibitors of mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83d79493cf95c568c5c17dbd1abab638
https://doi.org/10.1002/chin.199145193
https://doi.org/10.1002/chin.199145193
Publikováno v:
Anticancer research. 15(5B)
4,6-Benzylidene-D-glucose (BG), is a known antitumour substance with low clinical toxicity. In order to increase the antitumour activity of BG a deuterated compound, 4,6-benzylidene-D-d1-glucose, denoted P-1013, was synthesised. P-1013 induced signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7ee661a82da37ca908dd77fd7479325
https://pubmed.ncbi.nlm.nih.gov/8572579
https://pubmed.ncbi.nlm.nih.gov/8572579
Publikováno v:
Transplantation proceedings. 26(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d16c747df9be34ac51fec7c675286d29
https://pubmed.ncbi.nlm.nih.gov/7998222
https://pubmed.ncbi.nlm.nih.gov/7998222
Publikováno v:
Anticancer research. 12(1)
Zilascorb (2H) (5,6-benzylidene-d1-L-ascorbic acid sodium salt), a derivative of deuterated benzaldehyde inducing reversible protein synthesis inhibition, was tested on human NHIK 3025 cells in combination with the anticancer drug cis-diamminedichlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1f60414239335305a264734492292ef
https://pubmed.ncbi.nlm.nih.gov/1567178
https://pubmed.ncbi.nlm.nih.gov/1567178
Publikováno v:
Anticancer research. 11(3)
Three different benzaldehyde derivatives (viz. beta-cyclodextrin benzaldehyde inclusion compound (CDBA), 4, 6-O-benzylidene-D-glucose (BG) and sodium benzylidene-ascorbate (SBA) have been shown to exert anticancer effects in patients without causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b282e053fa087da886e1b6621bdd976d
https://pubmed.ncbi.nlm.nih.gov/1888141
https://pubmed.ncbi.nlm.nih.gov/1888141
Autor:
J. de Vries, Kjetill Østgaard, M.J. Peters, Eppo Mulder, Kristen B. Eik-Nes, R. Oftebro, H.J. van der Molen
Publikováno v:
Molecular and Cellular Endocrinology. 11:309-323
Growth of cultured NHIK 3025 cells stemming from a carcinoma of the human uterine cervix can be stimulated by the androgens 4-androstene-3β,17β-diol and testosterone, but is not influenced by oestradiol. In the cytosol fraction of these cells testo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db2cafa6392594adccbd1d8dee136a5
https://doi.org/10.1016/0303-7207(78)90016-3
https://doi.org/10.1016/0303-7207(78)90016-3
Publikováno v:
British Journal of Cancer
Inactivation of NHIK 3025 cells ny the mitotic inhibitor NY 3170 (1-propargyl-5-chloropyrimidin-2-one) was measured as loss of colony-forming ability. NY 3170 at a concentration of 0.15 nM allowed no formation of colonies after 12 days of continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9fe6f7e5c0a271c934a6a038c511a1
https://doi.org/10.1038/bjc.1979.169
https://doi.org/10.1038/bjc.1979.169
Publikováno v:
Cell Proliferation. 13:163-171
The proliferation kinetics of cells of the line NHIK 1922 grown in vitro and as solid tumours in the athymic mutant nude mouse has been studied. In vitro, growth curves were determined for exponentially growing populations and for populations synchro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68097a5fc0bb659b989fe2634625c676
https://doi.org/10.1111/j.1365-2184.1980.tb00459.x
https://doi.org/10.1111/j.1365-2184.1980.tb00459.x
Publikováno v:
British Journal of Cancer
Cells from the established cell line NHIK 3025 were synchronized by repeated mitotic selections. Survival of the synchronized cells after treatment with haematoporphyrin and near-UV light was measured by testing the capacity of the cells to form macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0bb3d79976c0c40c480a98fab2ae9a
https://doi.org/10.1038/bjc.1979.8
https://doi.org/10.1038/bjc.1979.8