Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R. O. Pelkonen"'
Publikováno v:
European Journal of Clinical Pharmacology. 22:441-445
Liver blood flow and indices of hepatic drug metabolism (antipyrine elimination rate and cytochrome P-450 concentration in liver biopsy specimens) were studied in 19 epileptics on long-term anticonvulsant treatment, and in 18 controls. The size of th
Publikováno v:
European Journal of Clinical Pharmacology. 28:615-618
Serum low-density lipoprotein cholesterol and high-density lipoprotein cholesterol concentration and the ratio between them, major risk factors of coronary heart disease, and liver size were investigated in 18 subjects who were on enzyme-inducing ant
Publikováno v:
British Journal of Clinical Pharmacology. 5:71-76
1. The effect of inducing drug therapy on the relationship between in vitro (cytochrome P-450 content) and in vivo (antipyrine kinetics) was investigated by comparing eleven consecutively treated epileptics with two groups of controls, eleven subject
Publikováno v:
Diabetes. 29:788-794
Publikováno v:
European Journal of Clinical Pharmacology. 17:267-274
Three parameters of hepatic drug metabolism, cytochrome P-450 (P-450) content, antipyrine metabolism and urinary excretion of glucaric acid (GA) were investigated in 161 patients who underwent diagnostic liver needle biopsy. P-450 and antipyrine meta
Publikováno v:
British Journal of Clinical Pharmacology. 18:895-899
The effect of fatty degeneration of liver parenchyma on drug metabolism was investigated in 21 obese non-insulin-dependent diabetic subjects by measuring plasma antipyrine kinetics, hepatic cytochrome P-450, liver size and the extent of fatty infiltr
Publikováno v:
European Journal of Clinical Pharmacology. 11:295-303
The drug metabolizing capacity of the liver was investigated in 27 consecutive alcoholics by comparison of in vivo (antipyrine kinetics) and in vitro (cytochrome P-450) indices of drug metabolism with quantitative histological determinations of fat,
Publikováno v:
European Journal of Clinical Pharmacology. 27:727-732
The relationship between hepatic glycerolipids and microsomal drug-metabolizing enzymes was studied in liver biopsies from 41 subjects. The series included obese, diabetic, epileptic and chronic alcoholic patients, all of whom were hospitalized for s
Publikováno v:
Experientia. 32:1311-1313
Lipoperoxidation and drug-metabolizing enzymes were measured in livers and placentas of different mammal species during the perinatal perios. In placentas and fetal livers of rat, rabbit and guinea-pig, cofactor-supported lipoperoxidation was negligi
Publikováno v:
Research communications in chemical pathology and pharmacology. 37(1)
Plasma HDL cholesterol (HDL-C) and major apolipoproteins, A-I (A-I) and A-II (A-II), and indices of hepatic microsomal function, liver cytochrome P-450 (P-450) and plasma antipyrine clearance rate (AP-CL), in eight alcohol consumers and eight non-dri