Zobrazeno 1 - 10
of 552
pro vyhledávání: '"R. Neill"'
Autor:
Angharad E Green, Sian Pottenger, Manal S Monshi, Thomas E Barton, Marie Phelan, Daniel R Neill
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011630 (2023)
Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to environmental change. Pneumococcus is a nasopharyngeal commensal, but is responsible
Externí odkaz:
https://doaj.org/article/50d87ba9eb034ff59391986cb61099b8
Autor:
Laura C. Jacques, Angharad E. Green, Thomas E. Barton, Murielle Baltazar, Julia Aleksandrowicz, Rong Xu, Erwan Trochu, Aras Kadioglu, Daniel R. Neill
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The short generation time of many bacterial pathogens allows the accumulation of de novo mutations during routine culture procedures used for the preparation and propagation of bacterial stocks. Taking the major human pathogen Streptococcus
Externí odkaz:
https://doaj.org/article/de92f347b347461c935269ceef1608a9
Autor:
Rong Xu, Laura C. Jacques, Shadia Khandaker, Daan Beentjes, Miguel Leon-Rios, Xiaoqing Wei, Neil French, Daniel R. Neill, Aras Kadioglu
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112054- (2023)
Summary: Streptococcus pneumoniae is a pathogen of global morbidity and mortality. Pneumococcal pneumonia can lead to systemic infections associated with high rates of mortality. We find that, upon pneumococcal infection, pulmonary Treg cells are act
Externí odkaz:
https://doaj.org/article/5bd0903ad9fd4e9e86620d19bbfddae3
Autor:
Chowdhury M. Hasan, Sian Pottenger, Angharad E. Green, Adrienne A. Cox, Jack S. White, Trevor Jones, Craig Winstanley, Aras Kadioglu, Megan H. Wright, Daniel R. Neill, Joanne L. Fothergill
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Pseudomonas aeruginosa undergoes diversification during infection of the cystic fibrosis (CF) lung. Understanding these changes requires model systems that capture the complexity of the CF lung environment. We previously identified loss-of-function m
Externí odkaz:
https://doaj.org/article/22204499f90d4a298bfea430f8163726
Publikováno v:
F1000Research, Vol 11 (2022)
The respiratory tract is a compartmentalised and heterogenous environment. The nasopharynx and sinuses of the upper airways have distinct properties from the lungs and these differences may shape bacterial adaptation and evolution. Upper airway niche
Externí odkaz:
https://doaj.org/article/1f11b0ff41484b5da4e2637771e27865
Autor:
Alice E. Law, Rebecca K. Shears, Andrea A. Lopez Rodas, Richard K. Grencis, Philip J. Cooper, Daniel R. Neill, Aras Kadioglu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal car
Externí odkaz:
https://doaj.org/article/a8bb4f2f12d842e99dc75046011d68e1
Autor:
Laura C. Jacques, Stavros Panagiotou, Murielle Baltazar, Madikay Senghore, Shadia Khandaker, Rong Xu, Laura Bricio-Moreno, Marie Yang, Christopher G. Dowson, Dean B. Everett, Daniel R. Neill, Aras Kadioglu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight j
Externí odkaz:
https://doaj.org/article/4e3fa97f73434e33a5cdb4df33c7b5d6
Autor:
Holly R. Neill, Chris I. R. Gill, Emma J. McDonald, W. Colin McRoberts, L. Kirsty Pourshahidi
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Hypovitaminosis D is prevalent worldwide, with many populations failing to achieve the recommended nutrient intake (RNI) for vitamin D (10–20 μg/day). Owing to low vitamin D intakes, limited exposure to ultraviolet-B (UVB) induced dermal synthesis
Externí odkaz:
https://doaj.org/article/6670e541f39648b49235be1678c8ee1d
Publikováno v:
ACS Applied Materials & Interfaces. 15:20822-20832
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains. Antimicrobial-resistant nosocomial pathogens such as P. aeruginosa
Externí odkaz:
https://doaj.org/article/3258fe7fab244c2fa9168b384328561f