Zobrazeno 1 - 10
of 317
pro vyhledávání: '"R. Mould"'
Autor:
Ana‐Marija Milenković‐Grišić, Nadia Terranova, Diane R. Mould, Yulia Vugmeyster, Thomas Mrowiec, Andreas Machl, Pascal Girard, Karthik Venkatakrishnan, Akash Khandelwal
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 1, Pp 143-153 (2024)
Abstract This analysis aimed to quantify tumor dynamics in patients receiving either bintrafusp alfa (BA) or pembrolizumab, by population pharmacokinetic (PK)‐pharmacodynamic modeling, and investigate clinical and molecular covariates describing th
Externí odkaz:
https://doaj.org/article/f72495eac4e94dfc80362557b409a4e6
Autor:
Rhys R. Mould, Alasdair M. Mackenzie, Ifigeneia Kalampouka, Alistair V. W. Nunn, E. Louise Thomas, Jimmy D. Bell, Stanley W. Botchway
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Cells emit light at ultra-low intensities: photons which are produced as by-products of cellular metabolism, distinct from other light emission processes such as delayed luminescence, bioluminescence, and chemiluminescence. The phenomenon is known by
Externí odkaz:
https://doaj.org/article/b1a289b4ad994ed2977b70669fe740bd
Autor:
Alasdair M. Mackenzie, Holly E. Smith, Rhys R. Mould, Jimmy D. Bell, Alistair V.W. Nunn, Stanley W. Botchway
Publikováno v:
Journal of Photochemistry and Photobiology, Vol 19, Iss , Pp 100224- (2024)
It is well known that life has evolved to use and generate light, for instance, photosynthesis, vision and bioluminescence. What is less well known is that during normal metabolism, it can generate 1–100 photons s−1 cm–2 known as ultra-weak pho
Externí odkaz:
https://doaj.org/article/592851e2c1594e0a92504e3421c9c19d
Autor:
Maria L. Maccecchini, Diane R. Mould
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 582 (2024)
Posiphen is a small molecule that exhibits neuroprotective properties by targeting multiple neurotoxic proteins involved in axonal transport, synaptic transmission, neuroinflammation, and cell death. Its broad-spectrum effects make it a promising can
Externí odkaz:
https://doaj.org/article/8a36ad6f166045f293abfe862bdd207a
CHARACTERISTICS OF OLOKIZUMAB PHARMACOKINETICS IN PATIENTS WITH NOVEL CORONAVIRUS INFECTION COVID-19
Autor:
E. V. Tavlueva, E. V. Zernova, M. P. Kutepova, N. E. Kostina, V. S. Lesina, D. R. Mould, K. Ito, A. V. Zinchenko, A. N. Dolgorukova, M. V. Nikolskaya, M. S. Lemak, O. V. Filon, M. Yu. Samsonov
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 10, Iss 5, Pp 460-471 (2022)
The aim of the article is to study pharmacokinetic characteristics of intravenous olokizumab in patients with moderate COVID-19 to relieve a hyperinflammation syndrome.Materials and methods. The pharmacokinetic study was conducted as a part of a phas
Externí odkaz:
https://doaj.org/article/96b8864adb544463a121630b4d6598a5
Autor:
Rhys R. Mould, Ifigeneia Kalampouka, E. Louise Thomas, Geoffrey W. Guy, Alistair V. W. Nunn, Jimmy D. Bell
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
A wide variety of studies have reported some form of non-chemical or non-aqueous communication between physically isolated organisms, eliciting changes in cellular proliferation, morphology, and/or metabolism. The sources and mechanisms of such signa
Externí odkaz:
https://doaj.org/article/82439343b4ec45f59742af33dfe6bd88
Autor:
Donald J. Irby, Mustafa E. Ibrahim, Anees M. Dauki, Mohamed A. Badawi, Sílvia M. Illamola, Mingqing Chen, Yuhuan Wang, Xiaoxi Liu, Mitch A. Phelps, Diane R. Mould
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 4, Pp 291-308 (2021)
Abstract Missing or erroneous information is a common problem in the analysis of pharmacokinetic (PK) data. This may present as missing or inaccurate dose level or dose time, drug concentrations below the analytical limit of quantification, missing s
Externí odkaz:
https://doaj.org/article/4bf8b31dc4b54808be5ad450089a9a56
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 667-676 (2019)
10‐nitro‐9(E)‐octadec‐9‐enoic acid (CXA‐10), a novel nitro fatty acid compound, demonstrates potential as a therapeutic agent in multiple disease indications in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity
Externí odkaz:
https://doaj.org/article/d911526f138e460099d396cd566a3184
Autor:
Meliz Sahuri-Arisoylu, Rhys R. Mould, Noriko Shinjyo, S. W. Annie Bligh, Alistair V. W. Nunn, Geoffrey W. Guy, Elizabeth Louise Thomas, Jimmy D. Bell
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Acetate is one of the main short chain fatty acids produced in the colon when fermentable carbohydrates are digested. It has been shown to affect normal metabolism, modulating mitochondrial function, and fatty acid oxidation. Currently, there is no c
Externí odkaz:
https://doaj.org/article/795069ea182041f7a03cec3090d791e9
Autor:
Steven B. Woodley, Rhys R. Mould, Meliz Sahuri-Arisoylu, Ifigeneia Kalampouka, Anthony Booker, Jimmy D. Bell
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Quality control has been a significant issue in herbal medicine since herbs became widely used to heal. Modern technologies have improved the methods of evaluating the quality of medicinal herbs but the methods of adulterating them have also grown in
Externí odkaz:
https://doaj.org/article/c171d405196c4e07a8b577da84e69a05