Zobrazeno 1 - 10
of 427
pro vyhledávání: '"R. Molloy"'
Autor:
Jean-Frederic Olivier, David Langlais, Thiviya Jeyakumar, Maria J. Polyak, Luc Galarneau, Romain Cayrol, Hua Jiang, Kelly R. Molloy, Guoyue Xu, Harumi Suzuki, John LaCava, Philippe Gros, Nassima Fodil
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract CCDC88B is a risk factor for several chronic inflammatory diseases in humans and its inactivation causes a migratory defect in DCs in mice. CCDC88B belongs to a family of cytoskeleton-associated scaffold proteins that feature protein:protein
Externí odkaz:
https://doaj.org/article/d603e15e96f84a3bbb6cf6e92186e573
Autor:
Fred D Mast, Peter C Fridy, Natalia E Ketaren, Junjie Wang, Erica Y Jacobs, Jean Paul Olivier, Tanmoy Sanyal, Kelly R Molloy, Fabian Schmidt, Magdalena Rutkowska, Yiska Weisblum, Lucille M Rich, Elizabeth R Vanderwall, Nicholas Dambrauskas, Vladimir Vigdorovich, Sarah Keegan, Jacob B Jiler, Milana E Stein, Paul Dominic B Olinares, Louis Herlands, Theodora Hatziioannou, D Noah Sather, Jason S Debley, David Fenyö, Andrej Sali, Paul D Bieniasz, John D Aitchison, Brian T Chait, Michael P Rout
Publikováno v:
eLife, Vol 10 (2021)
The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic antibodies and urgently demands powerful new therapeutics that can resist viral escape. We therefore generated a large nanobody repertoire to saturate the distinct and hi
Externí odkaz:
https://doaj.org/article/81f21ae91fa645928a68302720f1052b
Autor:
Zhanna Hakhverdyan, Kelly R. Molloy, Roman I. Subbotin, Javier Fernandez-Martinez, Brian T. Chait, Michael P. Rout
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100800- (2021)
Summary: We present a comprehensive and robust protocol to track the dynamics of all proteins in a complex in yeast cells. A single member of the protein assembly is tagged and conditionally expressed, minimizing the perturbations to the protein comp
Externí odkaz:
https://doaj.org/article/8f14c84eb3e346c589f3e578b975f3cc
Autor:
Daniel Ardeljan, Xuya Wang, Mehrnoosh Oghbaie, Martin S. Taylor, David Husband, Vikram Deshpande, Jared P. Steranka, Mikhail Gorbounov, Wan Rou Yang, Brandon Sie, H. Benjamin Larman, Hua Jiang, Kelly R. Molloy, Ilya Altukhov, Zhi Li, Wilson McKerrow, David Fenyö, Kathleen H. Burns, John LaCava
Publikováno v:
Mobile DNA, Vol 11, Iss 1, Pp 1-19 (2019)
Abstract Background Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and OR
Externí odkaz:
https://doaj.org/article/20049d0c7d7043acb41589f76709b424
Autor:
Kinga Winczura, Manfred Schmid, Claudia Iasillo, Kelly R. Molloy, Lea Mørch Harder, Jens S. Andersen, John LaCava, Torben Heick Jensen
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 44-58 (2018)
Summary: Nuclear RNA metabolism is influenced by protein complexes connecting to both RNA-productive and -destructive pathways. The ZC3H18 protein binds the cap-binding complex (CBC), universally present on capped RNAs, while also associating with th
Externí odkaz:
https://doaj.org/article/fa492696d2bd437c9e4a322a379dbb08
Autor:
Alexandra Santanach, Enrique Blanco, Hua Jiang, Kelly R. Molloy, Miriam Sansó, John LaCava, Lluis Morey, Luciano Di Croce
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of bo
Externí odkaz:
https://doaj.org/article/cf337e53504d4dbca5db1c546d985bc4
Akademický článek
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Akademický článek
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Autor:
Mirjam Hunziker, Jonas Barandun, Elisabeth Petfalski, Dongyan Tan, Clémentine Delan-Forino, Kelly R. Molloy, Kelly H. Kim, Hywel Dunn-Davies, Yi Shi, Malik Chaker-Margot, Brian T. Chait, Thomas Walz, David Tollervey, Sebastian Klinge
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Eukaryotic ribosome biogenesis involves a large number of maturations factors which are responsible for the stepwise assembly of the ribosomal subunits. Here the authors use an array of biochemical and structural biology methods to investigate the fu
Externí odkaz:
https://doaj.org/article/8f1bcb93f5c5482ca631db107b522b3f
Autor:
Sabrina M. Ronen, Russell O. Pieper, Joseph F. Costello, Pavithra Viswanath, Romelyn Delos Santos, Anne Marie Gillespie, Donghyun Hong, Abigail R. Molloy, Georgios Batsios, Chloe Najac, Marina Radoul, Elavarasan Subramani
Supplementary Figures S1-S9 and tables S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0749f05dbb0faf761f9479b34b394d
https://doi.org/10.1158/0008-5472.22426117
https://doi.org/10.1158/0008-5472.22426117
