Zobrazeno 1 - 10
of 153
pro vyhledávání: '"R. Milburn"'
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Genes identified as critical for CD70 ADC function in Library 1 screen (S1); Genes identified as critical for CD70 ADC function in Library 2 screen (S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd7b980e59ed2ae74732dbadbd5224
https://doi.org/10.1158/0008-5472.22406852
https://doi.org/10.1158/0008-5472.22406852
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Predicted topology for SLC46A3 (S1); Effect of siRNA on mRNA expression of SLC46A3 and CD70 in 786-0 cells (S2); Effect of siRNA on CD70 protein expression in 786-0 cells (S3); Anti-CD70 Ab-DSG-Maytansine and anti-CD70 Ab-Cys-Maytansine are potent ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eff3eb212c549f79dc7834903550168
https://doi.org/10.1158/0008-5472.22406858.v1
https://doi.org/10.1158/0008-5472.22406858.v1
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33716785c78c5ac8ae1ee739e76fa395
https://doi.org/10.1158/0008-5472.22406855.v1
https://doi.org/10.1158/0008-5472.22406855.v1
Autor:
Allison P. Jacob, Christopher J. Borths, Matthew M. Bio, Sophia Siu, Mark E. Tometsko, Kevin J. Hamblett, Jason W. O'Neill, Jesse L. Gurgel, Seamus Ragan, Margaret F. Weidner, William C. Fanslow, Brooke M. Rock, Wesley Chang, Kim Quon, Robert R. Milburn, Dan A. Rock, Sonal K. Patel
Publikováno v:
Cancer Research. 75:5329-5340
Antibody–drug conjugates (ADC) target cytotoxic drugs to antigen-positive cells for treating cancer. After internalization, ADCs with noncleavable linkers are catabolized to amino acid-linker-warheads within the lysosome, which then enter the cytop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c23aea6eea63c9112664b78d3d0eb62
https://doi.org/10.1158/0008-5472.can-15-1610
https://doi.org/10.1158/0008-5472.can-15-1610
Autor:
D, Blyth, J, Fry, N, Fomin, R, Alarcon, L, Alonzi, E, Askanazi, S, Baeßler, S, Balascuta, L, Barrón-Palos, A, Barzilov, J D, Bowman, N, Birge, J R, Calarco, T E, Chupp, V, Cianciolo, C E, Coppola, C B, Crawford, K, Craycraft, D, Evans, C, Fieseler, E, Frlež, I, Garishvili, M T W, Gericke, R C, Gillis, K B, Grammer, G L, Greene, J, Hall, J, Hamblen, C, Hayes, E B, Iverson, M L, Kabir, S, Kucuker, B, Lauss, R, Mahurin, M, McCrea, M, Maldonado-Velázquez, Y, Masuda, J, Mei, R, Milburn, P E, Mueller, M, Musgrave, H, Nann, I, Novikov, D, Parsons, S I, Penttilä, D, Počanić, A, Ramirez-Morales, M, Root, A, Salas-Bacci, S, Santra, S, Schröder, E, Scott, P-N, Seo, E I, Sharapov, F, Simmons, W M, Snow, A, Sprow, J, Stewart, E, Tang, Z, Tang, X, Tong, D J, Turkoglu, R, Whitehead, W S, Wilburn
Publikováno v:
Physical review letters. 121(24)
We report the first observation of the parity-violating gamma-ray asymmetry A_{γ}^{np} in neutron-proton capture using polarized cold neutrons incident on a liquid parahydrogen target at the Spallation Neutron Source at Oak Ridge National Laboratory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccde93ab22f40a3f743e6fdcd67f4d82
https://pubmed.ncbi.nlm.nih.gov/30608729
https://pubmed.ncbi.nlm.nih.gov/30608729
Autor:
Carl Davis, Qiong Wu, Oliver R. Thiel, Robert R. Milburn, Jodi L. Liu, Y.-H. Kiang, Eric A. Bercot, Christopher J. Borths, Robert E. Saw, Dawn E. Cohen, Richard J. Staples
Publikováno v:
Organic Process Research & Development. 19:1849-1858
AMG 579 (1) is a potent and selective phosphodiesterase 10 (PDE10A) inhibitor selected for clinical development for the treatment of schizophrenia. Extensive polymorph and salt screening identified two free-base anhydrous polymorphs (Form 1 and Form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b06eaa6b031c67cb79c311ae7587d8
https://doi.org/10.1021/acs.oprd.5b00031
https://doi.org/10.1021/acs.oprd.5b00031
Publikováno v:
Magnetic Resonance in Chemistry. 54:437-443
Monitoring chemical reactions is the key to controlling chemical processes where NMR can provide support. High-field NMR gives detailed structural information on chemical compounds and reactions; however, it is expensive and complex to operate. Conve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d276c5b2168a1492392f1800da7bb67f
https://doi.org/10.1002/mrc.4189
https://doi.org/10.1002/mrc.4189
Publikováno v:
Organic Process Research & Development. 18:1807-1811
The safe implementation of a hydrogen-peroxide-mediated oxidation of a poorly reactive sulfide to the corresponding sulfone is described. A three-tiered approach incorporating process understanding, safety studies, and real time PAT (in situ Raman sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c8c5eac9e4388d70831fe47e1c93ae
https://doi.org/10.1021/op500132s
https://doi.org/10.1021/op500132s
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Autor:
Brooke M. Rock, Kip P. Conner, Jason W. O'Neill, Mark E. Tometsko, Tiep Le, Kevin J. Hamblett, Justin N. Huard, Robert R. Milburn, Dan A. Rock, Sophia Siu, William C. Fanslow
Publikováno v:
Molecular pharmaceutics. 13(7)
Antibody-drug conjugates (ADC) rely on the target-binding specificity of an antibody to selectively deliver potent drugs to cancer cells. IgG antibody half-life is regulated by neonatal Fc receptor (FcRn) binding. Histidine 435 of human IgG was mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc19d98e0589e41f65bb7eea6be00ac
https://pubmed.ncbi.nlm.nih.gov/27248573
https://pubmed.ncbi.nlm.nih.gov/27248573