Zobrazeno 1 - 10
of 30
pro vyhledávání: '"R. Michael McClain"'
Publikováno v:
Food and Chemical Toxicology. 45:1319-1332
Genistein is a phytoestrogen that occurs naturally in the diet and is found in a wide variety of plant-derived foods especially in soybeans and soy-based foods. There is wide spread interest in genistein and related phytoestrogens as chemopreventive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d56cbda6720818115e4e540649c20f
https://doi.org/10.1016/j.fct.2007.01.009
https://doi.org/10.1016/j.fct.2007.01.009
Autor:
Ursula Rehkemper, David Sokal, John E. Dillberger, Thomas Smith, R. Michael McClain, Aida M. Cancel
Publikováno v:
International Journal of Toxicology. 25:109-118
Quinacrine is an acridine derivative under investigation for its use in nonsurgical female sterilization. Safety issues regarding the carcinogenic potential of quinacrine have been raised because it is mutagenic and clastogenic in vitro. The objectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e021cc4e8a0a0144248767bee7458cf
https://doi.org/10.1080/10915810600605773
https://doi.org/10.1080/10915810600605773
Publikováno v:
Food and Chemical Toxicology. 44:42-55
Genistein is a phytoestrogen that occurs naturally in the diet especially in soybeans and soy-based foods. Genistein and related phytoestrogens are of interest as chemopreventive agents for a variety of diseases and cancers based on epidemiologic evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233524e0120ed3ccb8db33dd7a220ff6
https://doi.org/10.1016/j.fct.2005.06.004
https://doi.org/10.1016/j.fct.2005.06.004
Autor:
R. Michael McClain, Jochen Bausch
Publikováno v:
Regulatory Toxicology and Pharmacology. 37:274-285
Lycopene belongs to the group of natural carotenoids, which are found in many fruits and vegetables, but predominantly in tomatoes and tomato-based products. This manuscript summarizes the safety of synthetic lycopene as a water-dispersible beadlet f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25970accabf98b399a40932b55ac759a
https://doi.org/10.1016/s0273-2300(03)00004-7
https://doi.org/10.1016/s0273-2300(03)00004-7
Autor:
Peter P. Fu, R. Michael Mcclain, John E. Sagartz, James A. Popp, Dan Casciano, James S. MacDonald, Douglas A. Keller
Publikováno v:
Toxicologic Pathology. 29:128-137
The neonatal mouse model, in various forms, has been used experimentally since 1959 and a large number of chemicals have been tested. The neonatal model is known to be very sensitive for the detection of carcinogens that operate via a genotoxic mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af15976547d304539a5af26ff8b1191
https://doi.org/10.1080/019262301753178537
https://doi.org/10.1080/019262301753178537
Publikováno v:
International Journal of Cancer. 72:491-497
Modifications to DNA-5-methylcytosine (5MeC) content (i.e., alterations in the level of 5MeC) constitute epigenetic events. In general, hypomethylation of a gene is necessary but not sufficient for expression, while methylated genes typically are qui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92749ecdfe08d5ac3c5186472d392741
https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<491::aid-ijc18>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<491::aid-ijc18>3.0.co
Autor:
J C Downing, Mehzad Shahsavari, Arthur S. Tischler, R. Michael McClain, Panayiotis Tsokas, James F. Powers, Jeffrey Ziar
Publikováno v:
Fundamental and Applied Toxicology. 35:216-220
Spontaneous and drug-induced pheochromocytomas are common in rats and rare in mice. The antihypertensive drug reserpine has been shown to both induce pheochromocytomas and stimulate chromaffin cell proliferation in rats, leading to the hypothesis tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e18a75ff3639d684aca26c901d285fc
https://doi.org/10.1006/faat.1996.2277
https://doi.org/10.1006/faat.1996.2277
Publikováno v:
Molecular Carcinogenesis. 18:97-106
The effects of different liver tumor-promoting treatments (i.e., a choline-devoid, methionine-deficient (CMD) diet, phenobarbital (PB), or both) on Ha-ras and raf methylation status and expression were determined in mouse strains with different susce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b73d8203b29bb68f8d45a1f87bde60
https://doi.org/10.1002/(sici)1098-2744(199702)18:2<97::aid-mc5>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199702)18:2<97::aid-mc5>3.0.co
Autor:
R. Michael McClain, Bernard M. Wagner
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 100(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869cc48ae6645e51d129c7a8e4dcfa9a
https://pubmed.ncbi.nlm.nih.gov/17934193
https://pubmed.ncbi.nlm.nih.gov/17934193
Autor:
Jochen Bausch, Alberto Davidovich, R. Michael McClain, Erich Wolz, James Edwards, Friedlieb Pfannkuch
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 44(1)
Genistein is a phytoestrogen that occurs naturally in the diet, especially in soy based foods. There is wide spread interest in phytoestrogens as chemopreventive agents for a variety of diseases and cancers based on epidemiologic evidence. Although s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beba529bc705d85693b4d1fbd374751b
https://pubmed.ncbi.nlm.nih.gov/16213646
https://pubmed.ncbi.nlm.nih.gov/16213646