Zobrazeno 1 - 10
of 62
pro vyhledávání: '"R. Michael Linden"'
Autor:
Francisco Zarate-Perez, Vishaka Santosh, Martino Bardelli, Leticia Agundez, R. Michael Linden, Els Henckaerts, Carlos Escalante
Publikováno v:
Bio-Protocol, Vol 7, Iss 6 (2017)
Quantitative measurement of proteins binding to DNA is a requisite to fully characterize the structural determinants of complex formation necessary to understand the DNA transactions that regulate cellular processes. Here we describe a detailed proto
Externí odkaz:
https://doaj.org/article/663a771875cb447cb459b08806ad0d56
Autor:
Karl Petri, Raffaele Fronza, Richard Gabriel, Christine Käppel, Ali Nowrouzi, R. Michael Linden, Els Henckaerts, Manfred Schmidt
Publikováno v:
BioTechniques, Vol 56, Iss 5, Pp 269-273 (2014)
The inverted terminal repeats (ITRs) of adeno-associated virus (AAV) are notoriously difficult to sequence owing to their high GC-content (70%) and palindromic sequences that result in the formation of a very stable, 125 bp long, T-shaped hairpin str
Externí odkaz:
https://doaj.org/article/dfd3b55790724b82a7519db0eea65caf
Autor:
Nathalie Clément, Gino Battaglioli, Ryan L. Jensen, Bruce C. Schnepp, Philip R. Johnson, Kirsten St. George, R. Michael Linden
Publikováno v:
Emerging Infectious Diseases, Vol 15, Iss 7, Pp 1149-1150 (2009)
Externí odkaz:
https://doaj.org/article/03279580fd78463080af954e5a252da1
Autor:
Michael Seyffert, Daniel L Glauser, Elisabeth M Schraner, Anna-Paula de Oliveira, Jorge Mansilla-Soto, Bernd Vogt, Hildegard Büning, R Michael Linden, Mathias Ackermann, Cornel Fraefel
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170908 (2017)
As their names imply, parvoviruses of the genus Dependovirus rely for their efficient replication on the concurrent presence of a helpervirus, such as herpesvirus, adenovirus, or papilloma virus. Adeno-associated virus 2 (AAV2) is such an example, wh
Externí odkaz:
https://doaj.org/article/62242f69c6874141a536152dc6e3da7d
Autor:
Leticia Agúndez, Sandra Dovero, Anders Björklund, Carl Rosenblad, André S L M Antunes, Elsa Y. Pioli, Els Henckaerts, R. Michael Linden, Qin Li, Tomas Björklund, Martino Bardelli, Erwan Bezard
Publikováno v:
Brain
Heterozygous variants in SOD1 are a major cause of familial amyotrophic lateral sclerosis. Park et al. report the first known case of SOD1 deficiency, a disorder distinct from ALS characterized by mild cerebellar atrophy and hyperekplexia-like sympto
Autor:
Francisco Zarate-Perez, Martino Bardelli, John W Burgner, Maria Villamil-Jarauta, Kanni Das, Demet Kekilli, Jorge Mansilla-Soto, R Michael Linden, Carlos R Escalante
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002764 (2012)
The four Rep proteins of adeno-associated virus (AAV) orchestrate all aspects of its viral life cycle, including transcription regulation, DNA replication, virus assembly, and site-specific integration of the viral genome into the human chromosome 19
Externí odkaz:
https://doaj.org/article/8383382c475e49a99b405c2aa629f43c
Autor:
Joshua A. Hull, Els Henckaerts, Antonette Bennett, Cathleen Hagemann, R. Michael Linden, Paul R. Chipman, Felix Broecker, Duncan Sousa, Katie Moss, Mavis Agbandje-McKenna, Peter H. Seeberger, Julie Tordo, Nelly Jolinon, Mario Mietzsch, Enswert Binns, Andrea Serio, Robert McKenna
Publikováno v:
J Struct Biol
Adeno-associated viruses (AAV) are utilized as gene transfer vectors in the treatment of monogenic disorders. A variant, rationally engineered based on natural AAV2 isolates, designated AAV-True Type (AAV-TT), is highly neurotropic compared to wild t
Autor:
Rebecca J. Holley, Michaël Hocquemiller, Brian W. Bigger, R. Michael Linden, Aiyin Liao, Els Henckaerts, Anna L. Gray, Nuria Palomar, Helen Parker, Olivier Danos, Amir Saam Youshani, Jessica T. Taylor, Hélène F.E. Gleitz, Claire O'Leary, Leticia Agúndez
Publikováno v:
Gray, A L, O'Leary, C, Liao, A, Agúndez, L, Youshani, A S, Gleitz, H F, Parker, H, Taylor, J T, Danos, O, Hocquemiller, M, Palomar, N, Linden, R M, Henckaerts, E, Holley, R J & Bigger, B W 2019, ' An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA ', Human Gene Therapy, vol. 30, no. 9, pp. 1052-1066 . https://doi.org/10.1089/hum.2018.189
Patients with the lysosomal storage disease mucopolysaccharidosis IIIA (MPSIIIA) lack the lysosomal enzyme N-sulfoglucosamine sulfohydrolase (SGSH), one of the many enzymes involved in degradation of heparan sulfate. Build-up of un-degraded heparan s
Autor:
Martino Bardelli, Carlos R. Escalante, Francisco Zarate-Perez, Anita F. Meier, R. Michael Linden, Matxalen Llosa, Els Henckaerts, Leticia Agúndez
Publikováno v:
PLoS One. 2018 Jul 17;13(7):e0200841
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Agúndez, L, Zárate-Pérez, F, Meier, A F, Bardelli, M, Llosa, M, Escalante, C R, Linden, R M & Henckaerts, E 2018, ' Exchange of functional domains between a bacterial conjugative relaxase and the integrase of the human adeno-associated virus ', PLoS ONE, vol. 13, no. 7, e0200841 . https://doi.org/10.1371/journal.pone.0200841
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200841 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Agúndez, L, Zárate-Pérez, F, Meier, A F, Bardelli, M, Llosa, M, Escalante, C R, Linden, R M & Henckaerts, E 2018, ' Exchange of functional domains between a bacterial conjugative relaxase and the integrase of the human adeno-associated virus ', PLoS ONE, vol. 13, no. 7, e0200841 . https://doi.org/10.1371/journal.pone.0200841
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200841 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
© 2018 Agúndez et al.
Endonucleases of the HUH family are specialized in processing single-stranded DNA in a variety of evolutionarily highly conserved biological processes related to mobile genetic elements. They share a structurally defined
Endonucleases of the HUH family are specialized in processing single-stranded DNA in a variety of evolutionarily highly conserved biological processes related to mobile genetic elements. They share a structurally defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4962ffc4de5ac33f70aed02fb2358ca6
http://hdl.handle.net/10902/14205
http://hdl.handle.net/10902/14205
Autor:
Helen M. Rowe, R. Michael Linden, Els Henckaerts, Sarah Smith-Moore, Mathieu Bollen, Cornel Fraefel, Stuart J. D. Neil
Publikováno v:
Smith-Moore, S, Neil, S J D, Fraefel, C, Linden, R M, Bollen, M, Rowe, H M & Henckaerts, E 2018, ' Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 15, pp. E3529-E3538 . https://doi.org/10.1073/pnas.1721883115
Adeno-associated virus (AAV) is a small humanwhose low immunogenicity and capacity for long-term persistence have led to its widespread use as vector for gene therapy. Despite great recent successes in AAV-based gene therapy, further improvements in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfedab73c1c5e3240fcae0a5f6be86b
https://kclpure.kcl.ac.uk/en/publications/7af5516d-aa1a-4f2d-a5db-a0aecb999ae4
https://kclpure.kcl.ac.uk/en/publications/7af5516d-aa1a-4f2d-a5db-a0aecb999ae4