Zobrazeno 1 - 10
of 68
pro vyhledávání: '"R. Michael Lawrence"'
Autor:
Jing Yang, Claudio Mapelli, Zhaoqing Wang, Chi Shing Sum, Ji Hua, R. Michael Lawrence, Yan Ni, Dietmar A. Seiffert
Publikováno v:
Platelets, Vol 33, Iss 7, Pp 979-986 (2022)
Protease-activated receptor 4 (PAR4) is a promising drug target to improve the efficacy/safety window of antiplatelet agents. The native peptide GYPGQV, and the more-potent peptide AYPGKF, are PAR4-specific activators. However, these PAR4 agonist pep
Externí odkaz:
https://doaj.org/article/da63be13adb74a87bc2112cc0441e456
Autor:
Purnima Khandelwal, Steven Stryker, Hannguang Chao, Nelly Aranibar, R. Michael Lawrence, Malavi Madireddi, Wenjun Zhao, Luping Chen, Michael D. Reily
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1366-1374 (2014)
A method is described that allows noninvasive identification and quantitative assessment of lipid classes present in sebaceous excretions in rodents. The method relies on direct high-field proton NMR analysis of common group lipid protons in deuterat
Externí odkaz:
https://doaj.org/article/aa6b392a884c480a8e7b7c8ce4625117
Autor:
Jacques Y. Roberge, Guixue Yu, Amarendra Mikkilineni, Ximao Wu, Yeheng Zhu, R. Michael Lawrence, William R. Ewing
Publikováno v:
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
Externí odkaz:
https://doaj.org/article/354d14f1bfc542a0ac1e7157fd9b7867
Autor:
Brent A. Rupnow, Tai W. Wong, R. Michael Lawrence, Malavi T. Madireddi, Jun Zhu, Wen-Pin Yang, Benjamin J. Henley, Joseph Fargnoli, Rolf-Peter Ryseck, Xinyu Wang, Jonathan G. Pabalan, Urvashi V. Roongta
PDF file - 70K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5f19996f7b7be9db5b7fb7f371b35a
https://doi.org/10.1158/1541-7786.22518582
https://doi.org/10.1158/1541-7786.22518582
Autor:
Brent A. Rupnow, Tai W. Wong, R. Michael Lawrence, Malavi T. Madireddi, Jun Zhu, Wen-Pin Yang, Benjamin J. Henley, Joseph Fargnoli, Rolf-Peter Ryseck, Xinyu Wang, Jonathan G. Pabalan, Urvashi V. Roongta
PDF file - 71K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26056af1bb8f6abaaf3538a0f9578a1c
https://doi.org/10.1158/1541-7786.22518573
https://doi.org/10.1158/1541-7786.22518573
Autor:
Brent A. Rupnow, Tai W. Wong, R. Michael Lawrence, Malavi T. Madireddi, Jun Zhu, Wen-Pin Yang, Benjamin J. Henley, Joseph Fargnoli, Rolf-Peter Ryseck, Xinyu Wang, Jonathan G. Pabalan, Urvashi V. Roongta
PDF file - 70K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec24b96c95c22de17c639d58869cf8e
https://doi.org/10.1158/1541-7786.22518576.v1
https://doi.org/10.1158/1541-7786.22518576.v1
Autor:
Brent A. Rupnow, Tai W. Wong, R. Michael Lawrence, Malavi T. Madireddi, Jun Zhu, Wen-Pin Yang, Benjamin J. Henley, Joseph Fargnoli, Rolf-Peter Ryseck, Xinyu Wang, Jonathan G. Pabalan, Urvashi V. Roongta
Emerging literature suggests that metabolic pathways play an important role in the maintenance and progression of human cancers. In particular, recent studies have implicated lipid biosynthesis and desaturation as a requirement for tumor cell surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1744961da814489eb070a9b55c9e7207
https://doi.org/10.1158/1541-7786.c.6542004
https://doi.org/10.1158/1541-7786.c.6542004
Autor:
Brent A. Rupnow, Tai W. Wong, R. Michael Lawrence, Malavi T. Madireddi, Jun Zhu, Wen-Pin Yang, Benjamin J. Henley, Joseph Fargnoli, Rolf-Peter Ryseck, Xinyu Wang, Jonathan G. Pabalan, Urvashi V. Roongta
PDF file - 39K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8112b61c9fece78abeaaa07d5a8f9ff9
https://doi.org/10.1158/1541-7786.22518579.v1
https://doi.org/10.1158/1541-7786.22518579.v1
Autor:
James Kempson, Xiaoping Hou, Jung-Hui Sun, Michael Wong, Joseph Pawluczyk, Jianqing Li, Subramaniam Krishnananthan, Eric M. Simmons, Yi Hsiao, Yi-Xin Li, Dawn Sun, Dauh-Rurng Wu, Wei Meng, Saleem Ahmad, Lidet Negash, Robert Brigance, Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Pratik Devasthale, Jeffrey A. Robl, Arvind Mathur
Publikováno v:
Organic Process Research & Development. 26:1327-1335
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35fda97669790a07bfdfb80a55523b6b
https://doi.org/10.1021/acs.oprd.2c00036
https://doi.org/10.1021/acs.oprd.2c00036
Autor:
Shu Chang, Anthony V. Azzara, Yi-Xin Li, Marta Dabros, James Kempson, Reshma Panemangelor, Huji Turdi, Kimberly A. Foster, William J. Keim, Jean M. Whaley, Jeffrey A. Robl, Fang Moore, Luping Chen, Mary Jane Cullen, Xiaoping Hou, Atsu Apedo, R. Michael Lawrence, Arvind Mathur, David G. Harden, Wei Meng, Kevin O'Malley, Mary Ann Pelleymounter, Hannguang Chao, Pratik Devasthale, Jon J. Hangeland, Zhengping Ma, Dauh-Rurng Wu, Robert Paul Brigance, Guohua Zhao, Lynn M. Abell, Qi Gao, Susan Harvey, Lisa M. Kopcho, Dong Cheng, Elizabeth A. Dierks, Ching-Hsuen Chu, Suzanne Rooney, Xiang-Yang Ye, Saleem Ahmad, Wei Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14773-14792
MGAT2 inhibition is a potential therapeutic approach for the treatment of metabolic disorders. High-throughput screening of the BMS internal compound collection identified the aryl dihydropyridinone compound 1 (hMGAT2 IC50 = 175 nM) as a hit. Compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90999a2854f1a395c0459b5cd876d
https://doi.org/10.1021/acs.jmedchem.1c01356
https://doi.org/10.1021/acs.jmedchem.1c01356