Zobrazeno 1 - 10
of 95
pro vyhledávání: '"R. Michael Garavito"'
Autor:
R. Michael Garavito
Publikováno v:
Crystallization of Membrane Proteins ISBN: 9781351071277
Crystallization of Membrane Proteins
Crystallization of Membrane Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196e6361f4a11b9c3ada9db7e3ad5556
https://doi.org/10.1201/9781351071277-4
https://doi.org/10.1201/9781351071277-4
Publikováno v:
Pharmacological Research. 99:404-409
The translocator protein 18 kDa (TSPO) has been the focus of intense research by the biomedical community and the pharmaceutical industry because of its apparent involvement in many disease-related processes. These include steroidogenesis, apoptosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd66c91ed887534d892fbccde565504
https://doi.org/10.1016/j.phrs.2015.03.022
https://doi.org/10.1016/j.phrs.2015.03.022
Publikováno v:
Science. 347:555-558
Structural clues to protein function Translocator protein (TSPO) is a mitochondrial membrane protein thought to transport cholesterol and porphyrins. Its detailed function remains unclear, but interest in it is high because TSPO is involved in a vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396efea3dc6a108aff2663ade20f1f42
https://doi.org/10.1126/science.1260590
https://doi.org/10.1126/science.1260590
Autor:
R. Michael Garavito, Gina M. Clayton, Kebreab Ghebreselasie, Lawrence J. Marnett, Daniel J. Hermanson, Surajit Banerjee, Shu Xu
Publikováno v:
Journal of Biological Chemistry. 289:6799-6808
Oxicams are widely used nonsteroidal anti-inflammatory drugs (NSAIDs), but little is known about the molecular basis of the interaction with their target enzymes, the cyclooxygenases (COX). Isoxicam is a nonselective inhibitor of COX-1 and COX-2 wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7cfdf96fae51c57d55e99f3bb4b780
https://doi.org/10.1074/jbc.m113.517987
https://doi.org/10.1074/jbc.m113.517987
Autor:
Andrea Bräutigam, Kevin M. Carr, Andreas P.M. Weber, R. Michael Garavito, Roshan P. Shrestha, Gerald Schönknecht, Stefan A. Rensing, Nicholas E. Dickenson, David Gagneul, Wei-Hua Chen, Mario Stanke, Christine Oesterhelt, Brett J. Baker, Martin J. Lercher, Guillaume G. Barbier, Chad M. Ternes, Curtis G. Wilkerson, Jillian F. Banfield
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2013, 339 (6124), pp.1207-1210. ⟨10.1126/science.1231707⟩
Science, American Association for the Advancement of Science, 2013, 339 (6124), pp.1207-1210. ⟨10.1126/science.1231707⟩
Hot, Toxic Eukaryote Unusually, the single-celled eukaryote red alga, Galdieria sulphuraria , can thrive in hot, acidic springs. This organism is endowed with extraordinary metabolic talents and can consume a variety of strange carbohydrates, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b339bbf6affe215cbd7918fbbb5be1
https://doi.org/10.1126/science.1231707
https://doi.org/10.1126/science.1231707
Translocator protein 18 kDa (TSPO) was previously known as the peripheral benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the mitochondrial outer membrane. Considerable evidence indicates that it plays regulatory roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48db00f8ba3f7ef4a89736c7d56016ec
https://europepmc.org/articles/PMC5125027/
https://europepmc.org/articles/PMC5125027/
Publikováno v:
Acta Biochimica et Biophysica Sinica. 43:996-1002
Succinic semialdehyde reductase (SSAR) is an important enzyme involved in γ-aminobutyrate (GABA) metabolism. By converting succinic semialdehyde (SSA) to γ-hydroxybutyrate (GHB), the SSAR facilitates an alternative pathway for GABA degradation. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fcde3aeef04ab92d37c54ab92911a35
https://doi.org/10.1093/abbs/gmr097
https://doi.org/10.1093/abbs/gmr097
Publikováno v:
Biochemical and Biophysical Research Communications. 407:674-679
The (pro)renin receptor (PRR) is an important component of the renin-angiotensin system (RAS), which regulates blood pressure and cardiovascular function. The integral membrane protein PRR contains a large extracellular domain (∼310 amino acids), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3df869a039ee12cf5ce97ff151c6400
https://doi.org/10.1016/j.bbrc.2011.03.074
https://doi.org/10.1016/j.bbrc.2011.03.074
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859:e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f84a90a69175fe025c91525bf1e0376c
https://doi.org/10.1016/j.bbabio.2018.09.018
https://doi.org/10.1016/j.bbabio.2018.09.018
Publikováno v:
Proceedings of the National Academy of Sciences. 106:16174-16179
Regulated intramembrane proteolysis (RIP) involves cleavage of a transmembrane segment of a protein. RIP governs diverse processes in a wide variety of organisms and is carried out by different types of intramembrane proteases (IPs), including a larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d07fa6ddc3f6fdd75e3927102aa5a8
https://doi.org/10.1073/pnas.0901455106
https://doi.org/10.1073/pnas.0901455106