Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R. Michael Baldwin"'
Publikováno v:
Clinical Pharmacokinetics
Background and Objective Ampreloxetine is a novel norepinephrine reuptake inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension. The objectives of this analysis were to define the pharmacokinetics of once-daily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905f2fe289278e43a972ab0d72b025f9
https://pubmed.ncbi.nlm.nih.gov/32856281
https://pubmed.ncbi.nlm.nih.gov/32856281
Publikováno v:
Clinical and Translational Science
TD-0714 is an orally active, potent, and selective inhibitor of human neprilysin (NEP) in development for the treatment of chronic heart failure. Oral administration of TD-0714 in rats resulted in dose-dependent and sustained increases in plasma cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac46cc89915394ee18aed21b173b7c8
https://pubmed.ncbi.nlm.nih.gov/32506827
https://pubmed.ncbi.nlm.nih.gov/32506827
Autor:
Annelie Lindqvist, Ylva Terelius, Anne Edenro, Susanne Löfgren, Masahiro Hiratsuka, Sarah C. Sim, Meint Schülke, R. Michael Baldwin, Anne Carlberg, Michael Snait, Magnus Ingelman-Sundberg, Ronny Fransson-Steen
Publikováno v:
Drug Metabolism and Disposition. 36:955-962
CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the metabolism of endogenous substrates, whereas the CYP2C18 enzyme is not expressed in human liver despite high mRNA expression. Mice transgenic for the human CYP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbad5cc93ccca51515b77214fd5ff2c
https://doi.org/10.1124/dmd.107.019349
https://doi.org/10.1124/dmd.107.019349
Autor:
Deanna L. Kroetz, Eric Jorgenson, Eric P. Winer, Lawrence N. Shulman, Yusuke Nakamura, John S. Witte, Joel Mefford, Howard L. McLeod, Kouros Owzar, Rachel J. Eclov, Mark J. Ratain, Clifford A. Hudis, Chen Jiang, Aparna Chhibber, Hitoshi Zembutsu, R. Michael Baldwin, Paula N. Friedman, Michiaki Kubo, Dorothy Watson
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 18(18)
Purpose: Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for the development of this toxicity. Experimental Design: A prospective pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e218b38e1dd15d5442ef681980940d
https://pubmed.ncbi.nlm.nih.gov/22843789
https://pubmed.ncbi.nlm.nih.gov/22843789
Autor:
Magnus Ingelman-Sundberg, Ophelia Q. P. Yin, Eileen B. Lawson, R. Michael Baldwin, Staffan Rosenborg, Dong-Seok Yim, Joseph D. Ma, Edmund V. Capparelli, Jerry C. Wu
Publikováno v:
European journal of clinical pharmacology. 68(4)
To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC(OPZ)) to its metabolites 5-hydroxyomeprazole (AUC(5OH)) and omeprazole sulfone (AUC(SUL)) as phenotyping parameters for cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59c109c956aea5b792605581b86d12e
https://pubmed.ncbi.nlm.nih.gov/22009190
https://pubmed.ncbi.nlm.nih.gov/22009190
Autor:
Myong Gong Lee, Aysha Taff, R. Michael Baldwin, Ching-Yu Lin, Charles G. Plopper, Arlean Rohde, Dexter Morin, Alan R. Buckpitt, Åsa M. Wheelock
Naphthalene and close structural analogues have been shown to cause necrosis of bronchiolar epithelial cells in mice by both inhalation exposure and by systemic administration. Cancer bioassays of naphthalene in mice have demonstrated a slight increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb0a22c22b00b1f3e7b9301cec92ba1
https://europepmc.org/articles/PMC2687406/
https://europepmc.org/articles/PMC2687406/
Autor:
Staffan Ohlsson, Magnus Ingelman-Sundberg, Leif Bertilsson, Erik Eliasson, Rasmus Steen Pedersen, Jessica Mwinyi, R. Michael Baldwin
Publikováno v:
British journal of clinical pharmacology. 65(5)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The only existing study of CYP2C19*17-associated alterations in drug pharmacokinetics was retrospective and compared probe drug metabolic ratios. • The CYP2C19*17 allele had been associated with a two- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839f75fcaff7e645f4425f983d3f8ad6
https://pubmed.ncbi.nlm.nih.gov/18294333
https://pubmed.ncbi.nlm.nih.gov/18294333
Autor:
Sarah C. Sim, R. Michael Baldwin, Erik Eliasson, Staffan Rosenborg, Leif Bertilsson, Magnus Ingelman-Sundberg, Rasmus Steen Pedersen, Jessica Mwinyi, Maria Andersson
Publikováno v:
European journal of clinical pharmacology. 64(12)
Ultrarapid drug metabolism of antidepressants has been associated with therapeutic failures. The CYP2C19*17 allele has been associated with higher levels of CYP2C19 gene transcription and increased rates of omeprazole and mephenytoin metabolism. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a07661cd8e3d5407e2f618c314f4ac
https://pubmed.ncbi.nlm.nih.gov/18654768
https://pubmed.ncbi.nlm.nih.gov/18654768
Autor:
Brandie Millen, Kathy S. Collins, Michael A. Shultz, David A. Putt, R. Michael Baldwin, Lawrence H. Lash, Poh Gek Forkert
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(10)
Pulmonary cytotoxicity induced by trichloroethylene (TCE) is associated with cytochrome P450-dependent bioactivation to reactive metabolites. In this investigation, studies were undertaken to test the hypothesis that TCE metabolism to chloral hydrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b190cb18aff3676303af6703d76e9b3d
https://pubmed.ncbi.nlm.nih.gov/15987776
https://pubmed.ncbi.nlm.nih.gov/15987776
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 312(2)
Naphthalene, a ubiquitous environmental contaminant, produces cytotoxicity in nonciliated bronchiolar epithelial (Clara) cells in mice; rats are refractory to lung cytotoxicity from naphthalene. In contrast, 1-nitronaphthalene is a potent toxicant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d21d25a32db918dd689291e81e360f9
https://pubmed.ncbi.nlm.nih.gov/15509722
https://pubmed.ncbi.nlm.nih.gov/15509722