Zobrazeno 1 - 10
of 532
pro vyhledávání: '"R. Mellor"'
Autor:
Sarah A. Stuart, Jon Palacios-Filardo, Aleks Domanski, Matt Udakis, Ian Duguid, Matt W. Jones, Jack R. Mellor
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Head-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be used to emulate the visual experience of movement during head fixation, but a low ine
Externí odkaz:
https://doaj.org/article/81ae3d55865b468bb1d35012ae5b3b70
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background Early life stress (ELS) is an important risk factor in the aetiology of depression. Developmental glucocorticoid exposure impacts multiple brain regions with the hippocampus being particularly vulnerable. Hippocampal mediated behaviours ar
Externí odkaz:
https://doaj.org/article/4e97efea32eb485694d5fb089286b964
Autor:
Maryam N. ALNasser, Ian R. Mellor
Publikováno v:
Journal of HerbMed Pharmacology, Vol 11, Iss 2, Pp 166-181 (2022)
Dietary interventions rich in fruits and vegetables in aging people can reverse or mitigate age-related cognitive declines, delay the onset of neurodegenerative diseases (NDDs), and provide long-term health dividends. The novel food, popularly known
Externí odkaz:
https://doaj.org/article/5bc78f8a3cc84eb7add5fca5e3db6a8b
Autor:
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Externí odkaz:
https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b
Autor:
Maryam N. ALNasser, Ayman M. AlSaadi, Alison Whitby, Dong-Hyun Kim, Ian R. Mellor, Wayne G. Carter
Publikováno v:
Life, Vol 13, Iss 4, p 1019 (2023)
Aberrant accumulation of the neurotransmitter L-glutamate (L-Glu) has been implicated as a mechanism of neurodegeneration, and the release of L-Glu after stroke onset leads to a toxicity cascade that results in neuronal death. The acai berry (Euterpe
Externí odkaz:
https://doaj.org/article/2375535ba15b42808b9a04dc717d4749
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporatin
Externí odkaz:
https://doaj.org/article/95ef49a5a5cf4af0b8a71422dec6512e
Publikováno v:
Toxics, Vol 11, Iss 3, p 279 (2023)
Pesticide exposure has been cited as a key threat to insect pollinators. Notably, a diverse range of potential sublethal effects have been reported in bee species, with a particular focus on effects due to exposure to neonicotinoid insecticides. Here
Externí odkaz:
https://doaj.org/article/00ba84a7e561422a8f6409c3d2005b10
Autor:
Mohamad Haiqal Nizar Mohamad, Izuddin Fahmy Abu, Muhammad Fattah Fazel, Renu Agarwal, Igor Iezhitsa, Norsham Juliana, Ian R. Mellor, Henrik Franzyk
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
N-methyl-D-aspartate receptor (NMDAR) overstimulation is known to mediate neurodegeneration, and hence represents a relevant therapeutic target for neurodegenerative disorders including glaucoma. This study examined the neuroprotective effects of phi
Externí odkaz:
https://doaj.org/article/a5e408556bb344d9974cd83fe8d88958
Autor:
Luke Y Prince, Travis Bacon, Rachel Humphries, Krasimira Tsaneva-Atanasova, Claudia Clopath, Jack R Mellor
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009435 (2021)
In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy fiber inputs from dentate gyrus granule cells. The neuromodulators acetylcho
Externí odkaz:
https://doaj.org/article/47bc763c170e4e65a94d6bba2615d3bd
Autor:
David P. Richards, Rohit N. Patel, Ian R. Duce, Bhupinder P. S. Khambay, Michael A. Birkett, John A. Pickett, Ian R. Mellor
Publikováno v:
Molecules, Vol 27, Iss 20, p 7074 (2022)
Ladybird beetles (Coleoptera: Coccinellidae) possess strong chemical defences that are secreted in response to stress and are also found on the coating of eggs, which are rich in alkaloids that are responsible for their toxicity to other species. Rec
Externí odkaz:
https://doaj.org/article/a1d8a3d609e74298b42062a3f07ec78d