Zobrazeno 1 - 10
of 1 172
pro vyhledávání: '"R. McFarland"'
Publikováno v:
IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol 32, Pp 2293-2301 (2024)
Introduction: Parkinson’s disease (PD) is characterized by motor symptoms whose progression is typically assessed using clinical scales, namely the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). Despite its reliab
Externí odkaz:
https://doaj.org/article/51c3b8a257014c7893a43a6fbe0a5ee3
Autor:
Bradley J. Wilkes, Emily R. Tobin, David J. Arpin, Wei-en Wang, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Objective measures of disease progression are critically needed in research on Parkinson’s disease (PD) and atypical Parkinsonism but may be hindered by both practicality and cost. The Purdue Pegboard Test (PPT) is objective, has high test
Externí odkaz:
https://doaj.org/article/7e8bb34fb98742c4bfda1a7e47ddb135
Autor:
Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. McKee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. McFarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni, Kenneth Marek, Anna Naito, Codrin Lungu, Daniel M. Corcos, The SPARX3-PSG Investigators
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-26 (2022)
Abstract Background To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question
Externí odkaz:
https://doaj.org/article/76455c85f6a1412282dc3e5f90536c78
Autor:
Ethan W. Hass, Zachary A. Sorrentino, Grace M. Lloyd, Nikolaus R. McFarland, Stefan Prokop, Benoit I. Giasson
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Multiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. The pathological hallmark of MSA is the progressive accumulation o
Externí odkaz:
https://doaj.org/article/cf85c8fa3b914cc08c99158b8d0595c7
Autor:
Rebecca L. Wallings, Laura P. Hughes, Hannah A. Staley, Zachary D. Simon, Nikolaus R. McFarland, Roy N. Alcalay, Alicia Garrido, María José Martí, Eduardo Tolosa Sarró, Nicolas Dzamko, Malú Gámez Tansey
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Both leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are promising targets for the treatment of Parkinson’s disease (PD). Evidence suggests that both proteins are involved in biological pathways involving the lysosome. However,
Externí odkaz:
https://doaj.org/article/b43410a08f0b43d2a8bc37fb45f77375
Autor:
Caroline M. Tanner, Steven R. Cummings, Michael A. Schwarzschild, Ethan G. Brown, E. Ray Dorsey, Alberto J. Espay, Nicholas B. Galifianakis, Samuel M. Goldman, Irene Litvan, Nijee Luthra, Nikolaus R. McFarland, Kyle T. Mitchell, David G. Standaert, Douglas C. Bauer, Susan L. Greenspan, James C. Beck, Kenneth W. Lyles
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-6 (2021)
Abstract The Trial of Parkinson’s And Zoledronic acid (TOPAZ, https://clinicaltrials.gov/ct2/show/NCT03924414 ) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approve
Externí odkaz:
https://doaj.org/article/de1c2ed76f6f4436af9d6293955c5287
Autor:
Trina Mitchell, Bradley J. Wilkes, Derek B. Archer, Winston T. Chu, Stephen A. Coombes, Song Lai, Nikolaus R. McFarland, Michael S. Okun, Mieniecia L. Black, Ellen Herschel, Tanya Simuni, Cynthia Comella, Mitra Afshari, Tao Xie, Hong Li, Todd B. Parrish, Ajay S. Kurani, Daniel M. Corcos, David E. Vaillancourt
Publikováno v:
NeuroImage: Clinical, Vol 34, Iss , Pp 103022- (2022)
Advanced diffusion imaging which accounts for complex tissue properties, such as crossing fibers and extracellular fluid, may detect longitudinal changes in widespread pathology in atypical Parkinsonian syndromes. We implemented fixel-based analysis,
Externí odkaz:
https://doaj.org/article/c8aca8e536474f0b81d9bbd39dcbe695
Autor:
Brent Bluett, Alexander Y. Pantelyat, Irene Litvan, Farwa Ali, Diana Apetauerova, Danny Bega, Lisa Bloom, James Bower, Adam L. Boxer, Marian L. Dale, Rohit Dhall, Antoine Duquette, Hubert H. Fernandez, Jori E. Fleisher, Murray Grossman, Michael Howell, Diana R. Kerwin, Julie Leegwater-Kim, Christiane Lepage, Peter Alexander Ljubenkov, Martina Mancini, Nikolaus R. McFarland, Paolo Moretti, Erica Myrick, Pritika Patel, Laura S. Plummer, Federico Rodriguez-Porcel, Julio Rojas, Christos Sidiropoulos, Miriam Sklerov, Leonard L. Sokol, Paul J. Tuite, Lawren VandeVrede, Jennifer Wilhelm, Anne-Marie A. Wills, Tao Xie, Lawrence I. Golbe
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS; the most common phenotype of corticobasal degeneration) are tauopathies with a relentless course, usually starting in the mid-60s and leading to death after an average of 7 years. T
Externí odkaz:
https://doaj.org/article/0194e9bab8b847dbbb83615232a6e800
Autor:
Claire N. Friedrichsen, Sheryl Hagen-Zakarison, Maren L. Friesen, Carol R. McFarland, Haiying Tao, J.D. Wulfhorst
Publikováno v:
Soil Security, Vol 2, Iss , Pp 100004- (2021)
The dominant research paradigm for soil health emphasizes instrumental values to achieve sustainable food systems. However, soil provides a plurality of values in society beyond instrumental value contributing to human well-being. This research aims
Externí odkaz:
https://doaj.org/article/b3efcea2dd0944de957eb89b138895d2
Autor:
Charlotte Henke MSc, Emily Mroz MS, PhDc, Ngoc Anh Le MPHc, Hannah M Gregory DOc, Ashley Ghiaseddin MD, Nikolaus R McFarland MD, PhD, Jacqueline Baron-Lee PhD
Publikováno v:
Journal of Patient Experience, Vol 7 (2020)
Background: Patient-centered care includes delineation of patient treatment values (ie, advance care planning [ACP]). Advance care planning often includes advance directive (AD) completion and is underutilized, particularly among neurology and neuros
Externí odkaz:
https://doaj.org/article/27a17956594a492b81346f09c068856f