Zobrazeno 1 - 10
of 357
pro vyhledávání: '"R. McArthur"'
Autor:
Celeste M Hackney, Paula Flórez Salcedo, Emilie Mueller, Thomas Lund Koch, Lau D Kjelgaard, Maren Watkins, Linda G Zachariassen, Pernille Sønderby Tuelung, Jeffrey R McArthur, David J Adams, Anders S Kristensen, Baldomero Olivera, Rocio K Finol-Urdaneta, Helena Safavi-Hemami, Jens Preben Morth, Lars Ellgaard
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002217 (2023)
Animal venom peptides represent valuable compounds for biomedical exploration. The venoms of marine cone snails constitute a particularly rich source of peptide toxins, known as conotoxins. Here, we identify the sequence of an unusually large conotox
Externí odkaz:
https://doaj.org/article/f3193ac4359d4247b682641281507d58
Autor:
Serena Viventi, Stefano Frausin, Sara E. Howden, Shiang Y. Lim, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Kwaku Dad Abu‐Bonsrah, Wayne Ng, Jason Ivanusic, Lachlan Thompson, Mirella Dottori
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 8, Pp 1157-1169 (2021)
Abstract Friedreich ataxia (FRDA) is an autosomal recessive disease characterized by degeneration of dorsal root ganglia (DRG) sensory neurons, which is due to low levels of the mitochondrial protein Frataxin. To explore cell replacement therapies as
Externí odkaz:
https://doaj.org/article/2403739491274763baadfc37b82dc9ee
Autor:
Neven Maksemous, Claire D. Blayney, Heidi G. Sutherland, Robert A. Smith, Rod A. Lea, Kim Ngan Tran, Omar Ibrahim, Jeffrey R. McArthur, Larisa M. Haupt, M. Zameel Cader, Rocio K. Finol-Urdaneta, David J. Adams, Lyn R. Griffiths
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Familial hemiplegic migraine (FHM) is a severe neurogenetic disorder for which three causal genes, CACNA1A, SCN1A, and ATP1A2, have been implicated. However, more than 80% of referred diagnostic cases of hemiplegic migraine (HM) are negative for exon
Externí odkaz:
https://doaj.org/article/483ec272a040492885598e5a29002b7f
Publikováno v:
eLife, Vol 11 (2022)
Low voltage-activated calcium currents are mediated by T-type calcium channels CaV3.1, CaV3.2, and CaV3.3, which modulate a variety of physiological processes including sleep, cardiac pace-making, pain, and epilepsy. CaV3 isoforms’ biophysical prop
Externí odkaz:
https://doaj.org/article/b2b6d6df713543bf80848474aae6e148
Akademický článek
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Autor:
Jeffrey R. McArthur, Nehan R. Munasinghe, Rocio K. Finol-Urdaneta, David J. Adams, Macdonald J. Christie
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Despite potently inhibiting the nociceptive voltage-gated sodium (Nav) channel, Nav1.7, µ-theraphotoxin Pn3a is antinociceptive only upon co-administration with sub-therapeutic opioid agonists, or by itself at doses >3,000-fold greater than its Nav1
Externí odkaz:
https://doaj.org/article/08d20781b23a4efa8934120da34df326
Autor:
Amy J. Hulme, Jeffrey R. McArthur, Simon Maksour, Sara Miellet, Lezanne Ooi, David J. Adams, Rocio K. Finol-Urdaneta, Mirella Dottori
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Sensory perception is fundamental to everyday life, yet understanding of human sensory physiology at the molecular level is hindered due to constraints on tissue availability. Emerging strategies to study and characterize peripheral neuropathies in v
Externí odkaz:
https://doaj.org/article/94af2641a3e049a59d23e5ade566ae78
Publikováno v:
Molecular Pharmacology. 102:196-208
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d87a62f2fb5d7cf3af9cd964f0232f
https://doi.org/10.1124/molpharm.122.000543
https://doi.org/10.1124/molpharm.122.000543
Autor:
Rocio K. Finol-Urdaneta, Aleksandra Belovanovic, Milica Micic-Vicovac, Gemma K. Kinsella, Jeffrey R. McArthur, Ahmed Al-Sabi
Publikováno v:
Marine Drugs, Vol 18, Iss 3, p 173 (2020)
Toxins from marine animals provide molecular tools for the study of many ion channels, including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity profiling and molecular investigation of these toxins have contributed to the d
Externí odkaz:
https://doaj.org/article/b5da2ee3669c4ca7bcfd661c1109d767
Publikováno v:
British Journal of Pharmacology. 179:179-198
BACKGROUND AND PURPOSE Activation of GIRK channels via G protein-coupled GABAB receptors has been shown to attenuate nociceptive transmission. The analgesic α-conotoxin Vc1.1 activates GABAB receptors resulting in inhibition of Cav 2.2 and Cav 2.3 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::debbacdc7e7f2eb161c0d3419935ba23
https://doi.org/10.1111/bph.15690
https://doi.org/10.1111/bph.15690