Zobrazeno 1 - 10
of 399
pro vyhledávání: '"R. Maxfield"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cardiovascular diseases remain the leading cause of death throughout the world. Accumulation of lipoprotein-associated lipids and their interaction with macrophages are early steps in the development of atherosclerotic lesions. For decades, it has be
Externí odkaz:
https://doaj.org/article/5cf1559c38e346cab5fa41c084149a79
Autor:
Nina H. Pipalia, Syed Z. Saad, Kanagaraj Subramanian, Abigail Cross, Aisha al-Motawa, Kunal Garg, Brian S.J. Blagg, Len Neckers, Paul Helquist, Olaf Wiest, Daniel S. Ory, Frederick R. Maxfield
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100114- (2021)
Niemann-Pick type C1 (NPC1) disease is a lysosomal lipid storage disorder caused by mutations of the NPC1 gene. More than 300 disease-associated mutations are reported in patients, resulting in abnormal accumulation of unesterified cholesterol, glyco
Externí odkaz:
https://doaj.org/article/524ce63d3936473ab0dc1113d787ce78
Autor:
Rajesh K. Singh, Abigail S. Haka, Alexandria Brumfield, Inna Grosheva, Priya Bhardwaj, Harvey F. Chin, Yuquan Xiong, Timothy Hla, Frederick R. Maxfield
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 10, Pp 1977-1987 (2017)
Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol
Externí odkaz:
https://doaj.org/article/e5661c0565b844518f2996af0079d911
Autor:
Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura, Heidi M. McBride
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-24 (2017)
Abstract Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and org
Externí odkaz:
https://doaj.org/article/57743286285748dc972d7417983b6f72
Autor:
Brittney R. Coats, Kelly Q. Schoenfelt, Valéria C. Barbosa-Lorenzi, Eduard Peris, Chang Cui, Alexandria Hoffman, Guolin Zhou, Sully Fernandez, Lijie Zhai, Ben A. Hall, Abigail S. Haka, Ajay M. Shah, Catherine A. Reardon, Matthew J. Brady, Christopher J. Rhodes, Frederick R. Maxfield, Lev Becker
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3149-3161 (2017)
During obesity, adipose tissue macrophages (ATMs) adopt a metabolically activated (MMe) phenotype. However, the functions of MMe macrophages are poorly understood. Here, we combine proteomic and functional methods to demonstrate that, in addition to
Externí odkaz:
https://doaj.org/article/9dd7d9447f5a4879beccbb036e888af5
Autor:
Nina H. Pipalia, Kanagaraj Subramanian, Shu Mao, Harold Ralph, Darren M. Hutt, Samantha M. Scott, William E. Balch, Frederick R. Maxfield
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 695-708 (2017)
Niemann-Pick C (NPC) disease is an autosomal recessive disorder that leads to excessive storage of cholesterol and other lipids in late endosomes and lysosomes. The large majority of NPC disease is caused by mutations in NPC1, a large polytopic membr
Externí odkaz:
https://doaj.org/article/0b6bea2e63ea4fa5ae88777be3306dfd
Autor:
Abigail S. Haka, Valéria C. Barbosa-Lorenzi, Hyuek Jong Lee, Domenick J. Falcone, Clifford A. Hudis, Andrew J. Dannenberg, Frederick R. Maxfield
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 6, Pp 980-992 (2016)
Many types of apoptotic cells are phagocytosed and digested by macrophages. Adipocytes can be hundreds of times larger than macrophages, so they are too large to be digested by conventional phagocytic processes. The nature of the interaction between
Externí odkaz:
https://doaj.org/article/859969a457454a34bf7f94d331d864d0
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
Autor:
David B. Iaea, Sarah E. Gale, Agata A. Bielska, Kathiresan Krishnan, Hideji Fujiwara, Hui Jiang, Frederick R. Maxfield, Paul H. Schlesinger, Douglas F. Covey, Jean E. Schaffer, Daniel S. Ory
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2408-2419 (2015)
Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback inhib
Externí odkaz:
https://doaj.org/article/b39cd01c69ac4c3ba074d9078dceaab5
Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’
Publikováno v:
eLife, Vol 7 (2018)
The plasma membrane in mammalian cells is rich in cholesterol, but how the cholesterol is partitioned between the two leaflets of the plasma membrane remains a matter of debate. Recently, Liu et al. used domain 4 (D4) of perfringolysin O as a cholest
Externí odkaz:
https://doaj.org/article/fcdef8d872ab4f0e904bdfac18af561f
Although considerable progress has been made in finding a therapy for Niemann-Pick type C1 (NPC1) disease, there still is no effective approved treatment. Previously, we reported results from a small molecule screen that was conducted on Chinese Hams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::833d02ab176040ee8e013e1270c39540
https://doi.org/10.1101/2022.11.16.516777
https://doi.org/10.1101/2022.11.16.516777
