Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R. Matthew Cross"'
Autor:
Dale L. Boger, Shouliang Yang, R. Matthew Cross, Daniel W. Carney, Aleksandar Radakovic, Daniel M. Brody, Vyom Shukla, John C. Lukesh, Katharine K. Duncan, Manuela M. Brütsch, Huijun Dong
Publikováno v:
Journal of Medicinal Chemistry. 60:7591-7604
A series of 180 vinblastine 20' amides were prepared in three steps from commercially available starting materials, systematically exploring a typically inaccessible site in the molecule enlisting a powerful functionalization strategy. Clear structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f59c28cf90ee2feb2751e99d442147
https://doi.org/10.1021/acs.jmedchem.7b00958
https://doi.org/10.1021/acs.jmedchem.7b00958
A key series of vinblastine analogs 7 – 13 , which contain modifications to the C20′ ethyl group, was prepared with use of two distinct synthetic approaches that provide modifications of the C20′ side chain containing linear and cyclized alkyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb7cb605d99b8006bc97e5a143e659e
https://europepmc.org/articles/PMC5538265/
https://europepmc.org/articles/PMC5538265/
Autor:
R. Matthew Cross, Kenneth O. Udenze, Jordany R. Maignan, Dennis E. Kyle, Fabián E. Sáenz, Roman Manetsch, Alexis N. LaCrue
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:6187-6195
Malaria kills approximately 1 million people a year, mainly in sub-Saharan Africa. Essential steps in the life cycle of the parasite are the development of gametocytes, as well as the formation of oocysts and sporozoites, in the Anopheles mosquito ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d9055e1771f28c3080a394f79d026f
https://doi.org/10.1128/aac.00492-13
https://doi.org/10.1128/aac.00492-13
Autor:
Fabián E. Sáenz, R. Matthew Cross, Alexis N. LaCrue, Andrii Monastyrskyi, Tina S. Mutka, Roman Manetsch, Steven Stein, Kenneth O. Udenze, Dennis E. Kyle
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:417-424
With the exception of primaquine, tafenoquine, and atovaquone, there are very few antimalarials that target liver stage parasites. In this study, a transgenic Plasmodium berghei parasite (1052Cl1; Pb GFP-Luc con ) that expresses luciferase was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe95a54d75fc99b5fa0da319f5b39005
https://doi.org/10.1128/aac.00793-12
https://doi.org/10.1128/aac.00793-12
Autor:
Dennis E. Kyle, Jordany R. Maignan, R. Matthew Cross, Tina S. Mutka, Justin Sargent, Roman Manetsch, Lisa Luong
Publikováno v:
Journal of Medicinal Chemistry. 54:4399-4426
Antimalarial activity of 1,2,3,4-tetrahydroacridin-9(10H)-ones (THAs) has been known since the 1940s and has garnered more attention with the development of the acridinedione floxacrine (1) in the 1970s and analogues thereof such as WR 243251 (2a) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ec406639afd69bc2fedf0dbbb0fa51
https://doi.org/10.1021/jm200015a
https://doi.org/10.1021/jm200015a
Autor:
Dennis E. Kyle, Roman Manetsch, Andrii Monastyrskyi, Jeremy N. Burrows, R. Matthew Cross, Tina S. Mutka
Publikováno v:
Journal of Medicinal Chemistry. 53:7076-7094
Since the 1940s endochin and analogues thereof were known to be causal prophylactic and potent erythrocytic stage agents in avian models. Preliminary screening in a current in vitro assay identified several 4(1H)-quinolones with nanomolar EC(50) agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a69db9459f5d691afefc9561510afdb
https://doi.org/10.1021/jm1007903
https://doi.org/10.1021/jm1007903
Autor:
Jessica Anne Steuten, Santiago Ferrer, Jeremy N. Burrows, Sandra Duffy, R. Matthew Cross, Rintis Noviyanti, Robert E. Sinden, Joanne M. Morrisey, Susan A. Charman, R. Kiplin Guy, Akhil B. Vaidya, Francisco-Javier Gamo, María Belén Jiménez-Díaz, Jutta Marfurt, Yuexin Li, Isaac P. Forquer, Jane X. Kelly, Dennis E. Kyle, Clemens H. M. Kocken, Peter Siegl, Laura M. Sanz, Roman Manetsch, Michael W. Mather, Ian Bathurst, Anne-Marie Zeeman, Vicky M. Avery, Eileen Ryan, Karen L. White, David M. Shackleford, Esperanza Herreros, Fabián E. Sáenz, Michael J. Delves, Michael K. Riscoe, Alexis N. LaCrue, Boni F. Sebayang, Iñigo Angulo-Barturen, Aaron Nilsen, Tina Mutka, Grennady Wirjanata, Ric N. Price, Rolf W. Winter
Publikováno v:
Science translational medicine
The goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of the disease. The 4(1H)-quinolone-3-diarylethers are selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06da36528ed6a76f7c51b0fff0fdb8b
https://doi.org/10.1126/scitranslmed.3005029
https://doi.org/10.1126/scitranslmed.3005029
Autor:
Lisa Luong, R. Matthew Cross, Tina S. Mutka, Roman Manetsch, Dennis E. Kyle, Niranjan K. Namelikonda
Publikováno v:
J Med Chem
ICI 56,780 (5) displayed causal prophylactic and blood schizonticidal activity (ED(50) = 0.05 mg/kg) in rodent malaria models, but produced rapid acquisition of parasitological resistance in P. berghei infected mice.(1) Herein we describe the synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8967784f814fa676a19bca265b1abe3b
https://europepmc.org/articles/PMC9247345/
https://europepmc.org/articles/PMC9247345/
Autor:
Roman Manetsch, R. Matthew Cross
Publikováno v:
ChemInform. 42
A divergent route was developed to access 3-iodo- and 6-chloro-3-iodo-4(1H)-quinolones for further elaboration via mono and/or sequential Suzuki-Miyaura cross-coupling to generate novel and medicinally important 4(1H)-quinolones. Copper- and palladiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2370e637b8af5b3283c53972cf0c783
https://doi.org/10.1002/chin.201114166
https://doi.org/10.1002/chin.201114166
Autor:
R. Matthew Cross, NiranjanK. Namelikonda, Tina S. Mutka, Lisa Luong, Dennis E. Kyle, Roman Manetsch
Publikováno v:
Journal of Medicinal Chemistry; Dec2011, Vol. 54 Issue 24, p8321-8327, 7p