Zobrazeno 1 - 10
of 454
pro vyhledávání: '"R. Mattern"'
Autor:
Kaitlyn Thatcher, Carol R. Mattern, Daniel Chaparro, Veronica Goveas, Michael R. McDermott, Jessica Fulton, Joshua D. Hutcheson, Brian R. Hoffmann, Joy Lincoln
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 8, p 355 (2023)
Organization of extracellular matrix (ECM) components, including collagens, proteoglycans, and elastin, is essential for maintaining the structure and function of heart valves throughout life. Mutations in ECM genes cause connective tissue disorders,
Externí odkaz:
https://doaj.org/article/2d6f5df9379543fbbdfb52af7c2481e5
Akademický článek
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Autor:
Jian Wu, Lijia Chen, Michael R. Mattern, Patrick R. Arsenault, Suresh Kumar, Feng Wang, Joseph Weinstock, Hui Wang
Publikováno v:
Journal of Medicinal Chemistry. 61:422-443
Ubiquitin specific protease 7 (USP7), the most widely studied among the nearly 100 deubiquitinating enzymes, supports cancer by positively affecting tumor growth and negatively affecting the patient's immune response to tumors. Great interest exists,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05fbcfedf6d6ec8cf0b95a3803b76d8
https://doi.org/10.1021/acs.jmedchem.7b00498
https://doi.org/10.1021/acs.jmedchem.7b00498
Author response for 'TAM receptors attenuate murine NK cell responses via E3 ubiquitin ligase Cbl‐b'
Autor:
Taku Kambayashi, Suresh Kumar, Leilani M. Chirino, Michael R. Mattern, Mariko Okumura, David E. Sterner, Tauseef R. Butt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49cf0b6c7638d5db693e472230869f0a
https://doi.org/10.1002/eji.201948204/v2/response1
https://doi.org/10.1002/eji.201948204/v2/response1
Autor:
David E. Sterner, Suresh Kumar, Michael R. Mattern, Leilani M. Chirino, Mariko Okumura, Taku Kambayashi, Tauseef R. Butt
Publikováno v:
Eur J Immunol
TAM receptors (Tyro3, Axl, and Mer) are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells. Although RTKs typically enhance cellular functions, TAM receptor ligation blocks NK-cell activation. The mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb453efea57f7adf2f0ded3db34582d9
https://pubmed.ncbi.nlm.nih.gov/31531847
https://pubmed.ncbi.nlm.nih.gov/31531847
Autor:
Feng Wang, Michael R. Mattern, Ivan Sokirniy, Thomas Bregnard, Jian Wu, Liqing Wang, Wayne W. Hancock, Irina Bezsonova, Suresh Kumar, Phuong H. Nguyen, Joseph Weinstock
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189744 (2017)
PLoS ONE
PLoS ONE
Accumulation of Foxp3+ T-regulatory (Treg) cells in the tumor microenvironment is associated with tumor immune evasion and poor patient outcome in the case of many solid tumors. Current therapeutic strategies for blocking Treg functions are not Treg-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428bc8d1ed0be6616297bc3250d9e550
http://europepmc.org/articles/PMC5728538?pdf=render
http://europepmc.org/articles/PMC5728538?pdf=render
Autor:
Saket Agarwal, David E. Sterner, Matthew P. Kodrasov, Michael R. Mattern, Suresh Kumar, Benjamin Nicholson, Jimmy Ming-Tai Wu, Michael J. Eddins, Jeffrey G. Marblestone, James P. LaRocque
Publikováno v:
SLAS Discovery. 19:989-999
The approval of proteasome inhibitors bortezomib and carfilzomib and the E3 ligase antagonist thalidomide and its analogs, lenalidomide and pomalidomide, validates the ubiquitin-proteasome pathway as a source of novel drugs for treating cancer and, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983b2a1c6e36a781c56ec904502405e7
https://doi.org/10.1177/1087057114527312
https://doi.org/10.1177/1087057114527312
Autor:
Michael J. Eddins, Jeffrey G. Marblestone, David E. Sterner, Benjamin Nicholson, Devin M. McKelvey, Michael R. Mattern, Samir Butt
Publikováno v:
Cell Biochemistry and Biophysics. 67:161-167
The ubiquitin pathway regulates diverse functions including protein localization and stability. The complexity of the pathway involving nearly 40 identified E2 conjugating enzymes and over 600 E3 ligases raises the issue of specificity. With the E2s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdbef2eaab86996e945916cbeeb59af
https://doi.org/10.1007/s12013-013-9627-3
https://doi.org/10.1007/s12013-013-9627-3
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823:2094-2097
The ubiquitin proteasome pathway controls the cellular degradation of ~80–90% of the proteome in a highly regulated manner. In this pathway, E3 ligases are responsible for the conjugation of ubiquitin to protein substrates which can lead to their d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c379fc3281dbb4169dc5c5e81e675784
https://doi.org/10.1016/j.bbamcr.2012.06.013
https://doi.org/10.1016/j.bbamcr.2012.06.013
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
The proteasome inhibitor bortezomib remains the only ubiquitin pathway effector to become a drug (VELCADE®) and has become a successful treatment for hematological malignancies. While producing a global cellular effect, proteasome inhibitors have no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a97f9f2bebc4264848a6add32ca764c
https://doi.org/10.1016/j.bbamcr.2012.05.005
https://doi.org/10.1016/j.bbamcr.2012.05.005