Zobrazeno 1 - 10
of 14
pro vyhledávání: '"R. Marcus Fancher"'
Autor:
Charles Mattis, Natalie Bratcher, Monika Burns, Christopher Carosino, Christina de Zafra, R. Marcus Fancher, Katrin Georgi, Candace Graff, Renee R. Hukkanen, Colena Johnson, Yanbin Lao, Amber Lange, Donna Lee, Michelle Lepherd, Sean Maguire, Mantas Malisauskas, Melinda Manuel, Sonia Miranda, Lori Reed, Rosemary Santos, Brian Sayers, David Shaw, David Shuster
Publikováno v:
International Journal of Toxicology. 41:291-296
The IQ Consortium NHP Reuse Working Group (WG) comprises members from 15 pharmaceutical and biotechnology companies. In 2020, the WG developed and distributed a detailed questionnaire on protein non-naïve NHP reuse to the WG member companies. The WG
Autor:
Li Zhu, Alban Allentoff, Christine Huang, Long Yuan, Kimberly Voronin, Renuka Pillutla, Peggy Liu-Kreyche, Naiyu Zheng, R. Marcus Fancher, Ramaswamy A. Iyer, Qin C Ji
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 165:198-206
Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography–mass spectrometry (LC–MS) bioanalytical assays. Recently, the application of SIL drugs and LC–
Autor:
R. Marcus Fancher, Hong Shen, Pawel D. Puszczalo, Shen-Jue Chen, Xue-Qing Chen, David J. Shuster, Cliff Chen, Zheng Yang, Yueping Zhang, Michael Sinz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(1)
Organic anion-transporting polypeptide (OATP) 1B induction is an evolving mechanism of drug disposition and interaction. However, there are contradictory reports describing OATP1B expression in hepatocytes and liver biopsies after administration of a
Autor:
Michael Sinz, Yang Hong, Jinping Gan, R. Marcus Fancher, Yurong Lai, Xiaomei Gu, Lifei Wang, Yuan Tian, Hong Shen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(8)
Despite a recent expansion in the recognition of coproporphyrin’s (CP9s) potential utility as an endogenous biomarker of OATP1B activity, there have been few detailed studies of C9s pharmacokinetic behavior and an overall poor understanding of its
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Autor:
R. Marcus Fancher, Prasad Krishnamurthy, Tongtong Liu, Xi Qiu, Cliff Chen, Hamza Kandoussi, Kristin Taylor, Sunil Sukrutharaj, Kathy Kuit, Jianing Zeng, Yurong Lai, A. David Rodrigues, Hao Jiang, Gabe Mintier, Craig Titsch, Hong Shen, Punit Marathe
Publikováno v:
Drug Metabolism and Disposition. 44:238-249
Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can serve as the loci of drug-drug interactions (DDI). To support the evaluation of cynomolgus mo
Autor:
R. Marcus Fancher, Elizabeth A. Dierks, Jamus MacGuire, Chiuwa E. Luk, James Smalley, Kimberly A. Foster, Evan B. Janovitz, Qin Sun, Hong Cai, Maxine Fox
Publikováno v:
Pharmacology Research & Perspectives
In this study, we describe a novel approach for collecting bile from dogs and cynomolgus monkeys for metabolite profiling, ultrasound‐guided cholecystocentesis (UCC). Sampling bile by UCC twice within 24 hours was well tolerated by dogs and monkeys
Autor:
Long Yuan, Mingshe Zhu, Li Ma, Anne-Françoise Aubry, Qin C Ji, Lisa Dillon, Huadong Sun, Lois D. Lehman-McKeeman, R. Marcus Fancher
Publikováno v:
Analytica chimica acta. 945
LC-MS/MS has been widely applied to the quantitative analysis of tissue samples. However, one key remaining issue is that the extraction recovery of analyte from spiked tissue calibration standard and quality control samples (QCs) may not accurately
Autor:
Ian Yates, Michael J. Hageman, Michael M. Morgen, R. Marcus Fancher, Olafur S. Gudmundsson, Kimberly A. Foster, Brice George Murri, Jon Ehrmann
Publikováno v:
International Journal of Pharmaceutics. 434:406-412
Target validation or demonstration of efficacy requires adequate in vivo exposure of tool molecules to determine their activity in order to validate the model or show the potential usefulness of the pharmacophore. Early discovery work is often carrie
Autor:
Yue-Zhong Shu, Li Ma, Goodrich Jason, R. Marcus Fancher, Makonen Belema, Mingshe Zhu, John E. Leet, W. Griffith Humphreys, Yang Hong, Min Gao, Lopez Omar D, Van N. Nguyen, Benjamin M. Johnson, Weiping Zhao, Wenying Li, Janet Caceres-Cortes, John A. Easter, Shu Y Chang, Xiaohong Liu, Xiaohua Huang, Lawrence G. Hamann
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(6)
Daclatasvir is a first-in-class, potent, and selective inhibitor of the hepatitis C virus nonstructural protein 5A replication complex. In support of nonclinical studies during discovery and exploratory development, liquid chromatography-tandem mass