Zobrazeno 1 - 10
of 27
pro vyhledávání: '"R. Marc Learned"'
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 550-565 (2019)
Fibroblast growth factor (FGF)19, an endocrine hormone produced in the gut, acts in the liver to control bile acid synthesis. NGM282, an engineered FGF19 analog, is currently in clinical development for treating nonalcoholic steatohepatitis. However,
Externí odkaz:
https://doaj.org/article/55c4c128b7544c74abd3f864605e688a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Fibroblast Growth Factor 19 (FGF19) neutralizing antibodies inhibit hepatocellular carcinoma (HCC) growth but have safety issues. Here, the authors show that FGF19 promotes HCC by activating STAT3 signalling via IL-6 production and that targeting IL-
Externí odkaz:
https://doaj.org/article/1666989d05a642a7880186e1fdbad158
Autor:
Lei Ling, Hui Tian, Alex M. DePaoli, R. Marc Learned, Taruna Arora, Xunshan Ding, Mark Humphrey, Hong Yang, Jer-Yuan Hsu, Kalyani Mondal, Darrin A. Lindhout, Van Phung, Xueyan Wang, Mei Zhou
PDF file - 142KB, Supplementary Table S1. Serum Parameters of db/db Mice After Continuous Exposure to FGF19 or M70 for 24 Weeks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fee3bc699f1740d0952d152d013b5cc
https://doi.org/10.1158/0008-5472.22403538
https://doi.org/10.1158/0008-5472.22403538
Publikováno v:
Hepatology Communications
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent chronic liver disease for which no approved therapies are available. Despite intensive research, the cellular mechanisms that mediate NAFLD pathogenesis and progression are poorly
Autor:
R. Marc Learned, Mei Zhou, Jian Luo, Michael Chen, Alex M. DePaoli, Hong Yang, Hui Tian, Lei Ling
Publikováno v:
Journal of Hepatology. 66:1182-1192
Bile acid nuclear receptor farnesoid X receptor (FXR) is a key molecular mediator of many metabolic processes, including the regulation of bile acid, lipid and glucose homeostasis. A significant component of FXR-mediated events essential to its biolo
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 60, Iss 3, Pp 550-565 (2019)
Journal of Lipid Research, Vol 60, Iss 3, Pp 550-565 (2019)
Fibroblast growth factor (FGF)19, an endocrine hormone produced in the gut, acts in the liver to control bile acid synthesis. NGM282, an engineered FGF19 analog, is currently in clinical development for treating nonalcoholic steatohepatitis. However,
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Hepatocellular carcinoma (HCC), a primary malignancy of the liver, is the second leading cause of cancer mortality worldwide. Fibroblast Growth Factor 19 (FGF19) is one of the most frequently amplified genes in HCC patients. Moreover, mice expressing
Autor:
Mei Zhou, Mark Humphrey, Van Phung, Xunshan Ding, Kalyani Mondal, R. Marc Learned, Xueyan Wang, Alex M. DePaoli, Taruna Arora, Jer-Yuan Hsu, Hui Tian, Lei Ling, Darrin A. Lindhout, Hong Yang
Publikováno v:
Cancer Research. 74:3306-3316
Hepatocellular carcinoma (HCC), one of the leading causes of cancer-related death, develops from premalignant lesions in chronically damaged livers. Although it is well established that FGF19 acts through the receptor complex FGFR4-β-Klotho (KLB) to
Autor:
Alykhan Motani, Juan C. Jaen, Helen Fuentes, Nigel Walker, Zhulun Wang, Lawrence R. McGee, Zexu Fang, Jocelyn Staunton, Jennifer Weiszmann, Qingxiang Liu, Jinsong Liu, Yang Li, Gary Lee, Jin-Long Chen, R. Marc Learned, Michelle Lindstrom, Donna H.T. Biermann
Publikováno v:
Journal of Molecular Biology. 386:1301-1311
The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR gamma; NR1C3) plays a central role in adipogenesis and is the molecular target of the thiazolidinedione class of antidiabetic drugs. To overcome the well-known shortc
Autor:
Noboru Furukawa, Patrick Escaron, Yang Li, Vidya Prasad, Nigel Walker, Olga Plotnikova, Jin-Long Chen, Jennifer Weiszmann, Zhulun Wang, Gary Lee, Haoda Xu, Jinsong Liu, R. Marc Learned, Michelle Lindstrom, Xiaohong Liu
Publikováno v:
Journal of Biological Chemistry. 283:9168-9176
The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma) plays central roles in adipogenesis and glucose homeostasis and is the molecular target for the thiazolidinedione (TZD) class of antidiabetic drugs. Activation