Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation?

Autor: C. Tersigni, S. D’Ippolito, F. Di Nicuolo, R. Marana, V. Valenza, V. Masciullo, F. Scaldaferri, F. Malatacca, C. de Waure, A. Gasbarrini, G. Scambia, N. Di Simone

Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-9 (2018)

Abstract Background Recurrent pregnancy loss (RPL) occurs in 3–5% in about 30% of cases no cause can be found. Women with RPL show higher prevalence of undiagnosed gut disorders. Furthermore, in endometrial tissues of RPL women, higher expression o

Externí odkaz: https://doaj.org/article/baf13409f9224010bcb288d4e9a01862

Male Fertility and Reduction in Semen Parameters: A Single Tertiary-Care Center Experience

Autor: D. Milardi, G. Grande, D. Sacchini, A. L. Astorri, G. Pompa, A. Giampietro, L. De Marinis, A. Pontecorvi, A. G. Spagnolo, R. Marana

Publikováno v: International Journal of Endocrinology, Vol 2012 (2012)

Background. Infertility is both a clinical and a public problem, affecting the life of the couple, the healthcare services, and social environment. Standard semen analysis is the surrogate measure of male fertility in clinical practice. Objective. To

Externí odkaz: https://doaj.org/article/bcf5772d7b8a432498c3287b25e02f35

A simple method to determine changes in the affinity between HisF and HisH in the Imidazole Glycerol Phosphate Synthase heterodimer.

Autor: Vitor M Almeida, J Patrick Loria, Sandro R Marana

Publikováno v: PLoS ONE, Vol 17, Iss 4, p e0267536 (2022)

The bi-enzyme HisF-HisH heterodimer is part of the pathway that produces histidine and purines in bacteria and lower eukaryotes, but it is absent in mammals. This heterodimer has been largely studied probing the basis of the allosteric effects and th

Externí odkaz: https://doaj.org/article/099cdaed7ad743b18e8d4d2d85eb85e3

Molecular Dynamics Reveals Complex Compensatory Effects of Ionic Strength on the Severe Acute Respiratory Syndrome Coronavirus 2 Spike/Human Angiotensin-Converting Enzyme 2 Interaction

Autor: Chuck S. Farah, Cristiane R. Guzzo, Anacleto Silva de Souza, Jose D. Rivera, Henning Ulrich, Pingju Ge, Roberto Kopke Salinas, Vitor Medeiros Almeida, Robson Francisco de Souza, Sandro R. Marana

Publikováno v: The Journal of Physical Chemistry Letters
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The SARS-CoV-2 pandemic has already killed more than one million people worldwide. To gain entry, the virus uses its Spike protein to bind to host hACE-2 receptors on the host cell surface and mediate fusion between viral and cell membranes. As initi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3491d1ba25cffc44c0ec011aaa13445f
https://doi.org/10.1021/acs.jpclett.0c02602

Sets of covariant residues modulate the activity and thermal stability of GH1 β-glucosidases.

Autor: Fábio K Tamaki, Larissa C Textor, Igor Polikarpov, Sandro R Marana

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96627 (2014)

The statistical coupling analysis of 768 β-glucosidases from the GH1 family revealed 23 positions in which the amino acid frequencies are coupled. The roles of these covariant positions in terms of the properties of β-glucosidases were investigated

Externí odkaz: https://doaj.org/article/e6912e8aa6554dbaaa5cc7c75985a4b2