Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R. Mako Saito"'
Autor:
Daniel J Chiu, R. Mako Saito, Barbara Conradt, Laura D Young, Joseph E. Clayton, Nadin Memar, Sarah H. Roy, Eleanor M. Beltz, Jenna Holmen, Travis H Green, Isabella Lubin, David V. Tobin, Yuying Liu
Publikováno v:
G3: Genes|Genomes|Genetics
The development and homeostasis of multicellular animals requires precise coordination of cell division and differentiation. We performed a genome-wide RNA interference screen in Caenorhabditis elegans to reveal the components of a regulatory network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38070d10fbcea3edd17ef919aec27364
http://europepmc.org/articles/PMC4025478
http://europepmc.org/articles/PMC4025478
Publikováno v:
Mechanisms of Development. 128:317-326
Much of our understanding of the function and regulation of the Cdc14 family of dual-specificity phosphatases originates from studies in yeasts. In these unicellular organisms Cdc14 is an important regulator of M-phase events. In contrast, the Caenor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a0b5f593fe637dc1f79dfec376534c
https://doi.org/10.1016/j.mod.2011.06.001
https://doi.org/10.1016/j.mod.2011.06.001
Publikováno v:
Cell Cycle. 8:2613-2620
Cyclin-dependent kinase inhibitors (CKIs) are major contributors to the decision to enter or exit the cell cycle. The Caenorhabditis elegans genome encodes two CKIs belonging to the Cip/Kip family, cki-1 and cki-2. cki-1 has been shown to act as a ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940e7f2c58e37c34a3ddcdac66c27645
https://doi.org/10.4161/cc.8.16.9354
https://doi.org/10.4161/cc.8.16.9354
Autor:
Gerhard Wagner, Sven G. Hyberts, Anne C. Hart, Amy K. Walker, Anders M. Näär, Rosalie DeBeaumont, Robert Tjian, Fajun Yang, Bryan W. Vought, R. Mako Saito, Lakshmanan K. Iyer, Jennifer L. Watts, Z.-Y. Jim Sun, John S. Satterlee, Christine Macol, Sander van den Heuvel, Shaosong Yang
Publikováno v:
Nature. 442:700-704
The sterol regulatory element binding protein (SREBP) family of transcription activators are critical regulators of cholesterol and fatty acid homeostasis. We previously demonstrated that human SREBPs bind the CREB-binding protein (CBP)/p300 acetyltr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad533106d8c3dffe674ded4d12e6cc67
https://doi.org/10.1038/nature04942
https://doi.org/10.1038/nature04942
Publikováno v:
Nature Cell Biology. 6:777-783
Temporal control of cell division is critical for proper animal development. To identify mechanisms involved in developmental arrest of cell division, we screened for cell-cycle mutants that disrupt the reproducible pattern of somatic divisions in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a104183f0f67f60b03610c3978cfe
https://doi.org/10.1038/ncb1154
https://doi.org/10.1038/ncb1154
Autor:
R. Mako Saito, Sander van den Heuvel
Publikováno v:
Cancer Investigation. 20:264-275
Developmental processes in the nematode C. elegans are controlled by pathways of gene functions that are analogous to those used in mammals. Hence, genetic studies in C. elegans have helped build the frameworks for these regulatory pathways. Many hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101cc19bd74d1a68abac849dde0a1358
https://doi.org/10.1081/cnv-120001153
https://doi.org/10.1081/cnv-120001153
During the development of the C. elegans reproductive system, cells that give rise to the vulva, the vulval precursor cells (VPCs), remain quiescent for two larval stages before resuming cell division in the third larval stage. We have identified sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012f0ca059ccb6932a14ce17c76c7bee
https://europepmc.org/articles/PMC2386670/
https://europepmc.org/articles/PMC2386670/
Autor:
Ginger R. Miley, Danielle Glossip, Douglas A. Fantz, Xiaowei Lu, R. Mako Saito, Kerry Kornfeld, Paul W. Sternberg, Sander van den Heuvel, Robert E. Palmer, Takao Inoue
Publikováno v:
Genetics. 167(4)
LIN-1 is an ETS domain protein. A receptor tyrosine kinase/Ras/mitogen-activated protein kinase signaling pathway regulates LIN-1 in the P6.p cell to induce the primary vulval cell fate during Caenorhabditis elegans development. We identified 23 lin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8765460df82de7afad8d6a0e5907d7
https://pubmed.ncbi.nlm.nih.gov/15342509
https://pubmed.ncbi.nlm.nih.gov/15342509
Publikováno v:
FEBS letters. 576(1-2)
We have investigated the physiological function of type 2 methionine aminopeptidases (MetAP2) using Caenorhabditis elegans as a model system. A homolog of human MetAP2 was found in the C. elegans genome, which we termed MAP-2. MAP-2 protein displayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8433208cc9f5bf384bfaa8fb84d54b2b
https://pubmed.ncbi.nlm.nih.gov/15474045
https://pubmed.ncbi.nlm.nih.gov/15474045
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