Výsledky vyhledávání - "R. M. Wadkins"

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin

Autor: M J, Hatfield, L, Tsurkan, J L, Hyatt, X, Yu, C C, Edwards, L D, Hicks, R M, Wadkins, P M, Potter

Publikováno v: British journal of pharmacology. 160(8)

Carboxylesterases (CEs) metabolize a wide range of xenobiotic substrates including heroin, cocaine, meperidine and the anticancer agent CPT-11. In this study, we have purified to homogeneity human liver and intestinal CEs and compared their ability w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29dd62fbfe2646afca5d682489b04a3a
https://pubmed.ncbi.nlm.nih.gov/20649590

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7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents

Autor: B, Vladu, J M, Woynarowski, G, Manikumar, M C, Wani, M E, Wall, D D, Von Hoff, R M, Wadkins

Publikováno v: Molecular pharmacology. 57(2)

7-Alkyl, 7-alkyl-10-hydroxy, 7-alkyl-10-methoxy, and 7-alkyl-10, 11-methylenedioxy analogs of camptothecin have been synthesized and evaluated for their ability to trap human DNA topoisomerase I in cleavable complexes. The 7-alkyl chain lengths varie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6771102b1ce09857abf6022613c7be0
https://pubmed.ncbi.nlm.nih.gov/10648633

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Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts

Autor: R M, Wadkins, P M, Potter, B, Vladu, J, Marty, G, Mangold, S, Weitman, G, Manikumar, M C, Wani, M E, Wall, D D, Von Hoff

Publikováno v: Cancer research. 59(14)

Water-soluble 20(S)-glycinate esters of two highly potent 10,11-methylenedioxy analogues of camptothecin (CPT) have been synthesized and evaluated for their ability to eradicate human breast cancer tumor xenografts. The glycinate ester moiety increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2394fd21d5a91dec5a774cd00da7855
https://pubmed.ncbi.nlm.nih.gov/10416605

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The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase

Autor: C L, Morton, R M, Wadkins, M K, Danks, P M, Potter

Publikováno v: Cancer research. 59(7)

Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitro assays confirmed that CPT-11 inhibited both human and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2003f0dd95d72d959622f08b5e9ae07e
https://pubmed.ncbi.nlm.nih.gov/10197614

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Biophysical aspects of P-glycoprotein-mediated multidrug resistance

Autor: R M, Wadkins, P D, Roepe

Publikováno v: International review of cytology. 171

In the 45 years since Burchenal's observation of chemotherapeutic drug resistance in tumor cells, many investigators have studied the molecular basis of tumor drug resistance and the phenomenon of tumor multidrug resistance (tumor MDR). Examples of M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee82781b937e3636cf1fa79918550dbb
https://pubmed.ncbi.nlm.nih.gov/9066127

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Thermodynamic Studies of Amsacrine Antitumor Agents with Nucleic Acids

Autor: R. M. Wadkins, D. E. Graves

Publikováno v: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ISBN: 9789401056571

The equilibrium binding of several anilinoacridine analogs are compared over a wide range of ionic strengths and temperatures. Although o-AMSA binds DNA with a higher affinity than m-AMSA it is not effective as an antitumor agent. Both m-AMSA and o-A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8429bad5759f09f4626e6d21add32602
https://doi.org/10.1007/978-94-011-3728-7_13

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