Výsledky vyhledávání - "R. M. W. Hoetelmans"

Addressing bedaquiline treatment interruptions in the treatment of drug-resistant TB

Autor: C. Kambili, S. Rossenu, R. M. W. Hoetelmans, E. Birmingham, N. Bakare

Publikováno v: Int J Tuberc Lung Dis

SETTING: The recommended dosing regimen for bedaquiline (BDQ), consisting of a 2-week loading phase (400 mg/day), followed by a maintenance phase (200 mg three times/week), might pose challenges when treatment is interrupted and needs to be reinitiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d0acc6cfc8ded205790a57e693d658
https://europepmc.org/articles/PMC9272739/

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Saliva as an alternative body fluid for therapeutic drug monitoring of the nonnucleoside reverse transcription inhibitor nevirapine

Autor: R. M. W. Hoetelmans, van Heeswijk Rp, J. W. Mulder, Pieter L. Meenhorst, Lange Jm, Jos H. Beijnen, A.I. Veldkamp

Publikováno v: Therapeutic drug monitoring, 23(3), 255-258. Lippincott Williams and Wilkins

The objective of this study was to evaluate the applicability of saliva as an alternative body fluid for therapeutic drug monitoring of nevirapine. The pharmacokinetics of nevirapine in plasma and saliva during a dosing interval was assessed in HIV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c19557453f6aa6d3298f20030e0007
https://doi.org/10.1097/00007691-200106000-00012

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Saliva as a Specimen for Monitoring Compliance But Not for Predicting Plasma Concentrations in Patients With HIV Treated With Indinavir

Autor: Y.A. Hekster, J. W. Mulder, Pieter L. Meenhorst, M.J.A. de Graaff, P.W.H. Hugen, David M. Burger, Kees Brinkman, R. M. W. Hoetelmans, Peter P. Koopmans, H.J.M. ter Hofstede

Publikováno v: Therapeutic Drug Monitoring, 22, 437-45
Therapeutic Drug Monitoring, 22, pp. 437-45

The presence of the HIV-protease inhibitor indinavir in saliva was analyzed to investigate whether salivary indinavir concentrations are applicable to monitor compliance and/or predict plasma indinavir levels. Fourteen HIV-infected outpatients treate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecf61021e8f219b1876dc6d5ddeb22f
https://doi.org/10.1097/00007691-200008000-00013

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Combination of Protease Inhibitors for the Treatment of HIV-1-Infected Patients: A Review of Pharmacokinetics and Clinical Experience

Autor: J. H. Beijnen, R. M. W. Hoetelmans, R. P. G. Van Heeswijk, J. W. Mulder, Al Veldkamp, Pieter L. Meenhorst, J. M. A. Lange

Publikováno v: Antiviral Therapy. 6:201-229

The use of highly active antiretroviral therapy, the combination of at least three different antiretroviral drugs for the treatment of HIV-1 infection, has greatly improved the prognosis for HIV-1-infected patients. The efficacy of a combination of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b1a52711fac3e9b6fe647c80f237501
https://doi.org/10.1177/135965350200600401

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Once-daily dosing of saquinavir and low-dose ritonavir in HIV-1-infected individuals: a pharmacokinetic pilot study

Autor: R. M. W. Hoetelmans, J. W. Mulder, Pieter L. Meenhorst, R. P. G. Van Heeswijk, J. M. A. Lange, Jos H. Beijnen, A.I. Veldkamp

Publikováno v: AIDS (London, England), 14(9), F103-F110. Lippincott Williams and Wilkins

Objective: To investigate the steady-state pharmacokinetics of a once-daily dosing regimen of saquinavir soft gelatin capsules in combination with a low dose of ritonavir in HIV-1-infected individuals. Design: Open-label, multi-dose, pharmacokinetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f169ce187bfb9c5c0cc4cc166e655d9b
https://doi.org/10.1097/00002030-200006160-00003

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Randomized trial comparing saquinavir soft gelatin capsules versus indinavir as part of triple therapy (CHEESE study)

Autor: B. Bravenboer, Clemens Richter, Dörte Hamann, Pieter L. Meenhorst, Herman G. Sprenger, Job R. Juttmann, David M. Burger, Peter P. Koopmans, Charles A. Boucher, J. C. C. Borleffs, J.W. Cohen Stuart, R. M. W. Hoetelmans, Rob Schuurman, Frank P. Kroon

Publikováno v: Aids, 13, 7, pp. F53-F58
Aids, 13, F53-F58

Objective: To compare efficacy and tolerability of saquinavir soft gelatin capsule (SQV-SGC) formulation and indinavir, both given as part of a triple drug regimen containing zidovudine and lamivudine, in HIV-1-infected individuals. Design: Randomize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821df07d2cce81dc6a08455e5ddc4e67
https://doi.org/10.1097/00002030-199905070-00001

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Co-Trimoxazole and Stavudine Interference in a High-Performance Liquid Chromatographic Analysis for Didanosine in Human Plasma

Autor: R. M. W. Hoetelmans, Pieter L. Meenhorst, J. W. Mulder, Monique Profijt, Jos H. Beijnen, R. P. G. Van Heeswijk

Publikováno v: Therapeutic Drug Monitoring. 20:669-672

Recently, the authors were confronted with interference of stavudine and co-trimoxazole when analyzing the antiretroviral drug didanosine (ddI) in plasma of HIV-1-infected patients using reverse-phase high-performance liquid chromatography with ultra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8558b119e4669695da9b9648c0e41700
https://doi.org/10.1097/00007691-199812000-00015

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The effect of plasma drug concentrations on HIV-1 clearance rate during quadruple drug therapy

Autor: F. De Wolf, G. J. Weverling, R. M. W. Hoetelmans, R. W. ten Kate, J. W. Mulder, Jos H. Beijnen, H. M. Weigel, P. H. J. Frissen, Marijke T. L. Roos, J. M. A. Lange, Hanneke Schuitemaker, Suzanne Jurriaans, M. H. E. Reijers, Ferdinand W. N. M. Wit

Publikováno v: AIDS (London, England), 12(11), F111-F115. Lippincott Williams and Wilkins

Objective: To investigate the relationship between exposure to antiretroviral drugs and the initial decline of plasma HIV-1 RNA. Design: Open-label study in antiretroviral-naive HIV-1 infected patients using a quadruple drug regimen [nelfinavir (NFV)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2028bf69810bd6f6bccacd6894eeac5c
https://doi.org/10.1097/00002030-199811000-00002

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Limited sampling strategies for the estimation of the systemic exposure to the HIV-1 nonnucleoside reverse transcriptase inhibitor nevirapine

Autor: J. W. Mulder, R. M. W. Hoetelmans, J. H. Beijnen, Pieter L. Meenhorst, Lange Jm, A.I. Veldkamp, van Heeswijk Rp

Publikováno v: Therapeutic drug monitoring, 23(6), 606-611. Lippincott Williams and Wilkins

The objective of this study was to develop and validate a limited sampling strategy (LSS) that allows accurate and precise estimation of the area under the plasma concentration versus time curve (AUC) of nevirapine, when used in the licensed dosage o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473b24bb1ed647e05db8fc46cd7c41c3
https://pure.amc.nl/en/publications/limited-sampling-strategies-for-the-estimation-of-the-systemic-exposure-to-the-hiv1-nonnucleoside-reverse-transcriptase-inhibitor-nevirapine(270fd036-c58a-4ce7-a6ae-8a95c0746055).html

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