Výsledky vyhledávání - "R. M. Vafina"

Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine

Autor: R. M. Khaziev, Mikhail V. Pugachev, Alfiya G. Iksanova, Marina I. Zeldi, R. M. Vafina, Nikita V. Shtyrlin, Elena V. Nikitina, Yu. G. Shtyrlin

Publikováno v: Russian Chemical Bulletin. 65:537-545

Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial and antitumor activity in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9852c7d49b0d841b9186594af7308baf
https://doi.org/10.1007/s11172-016-1334-y

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Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties

Autor: Airat R. Kayumov, Denis Yu. Grishaev, Mariya N. Agafonova, Sergey V. Sapozhnikov, Elena V. Nikitina, Alfiya G. Iksanova, Svetlana A. Lisovskaya, Alina E. Sabirova, Nikita V. Shtyrlin, Yurii G. Shtyrlin, Elena S. Krylova, Marsel R. Garipov, Renata R. Kazakova, Mikhail V. Pugachev, R. M. Vafina, Marina I. Zeldi, Roman S. Pavelyev

Publikováno v: Molecules
Molecules, Vol 25, Iss 4341, p 4341 (2020)
Volume 25
Issue 18

A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen&rsquo
s and acetal carbon was synthesized. Thirteen compounds exhibited antibacterial and antifungal activity (minimum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbd91dc09ef951c8ab0aa448b9c0df9
https://doi.org/10.3390/molecules25184341

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Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series

Autor: Svetlana A. Lisovskaya, Roman S. Pavelyev, O. I. Gnezdilov, Konstantin V. Balakin, Liliya E. Nikitina, R. M. Vafina, A. B. Dobrynin, G. A. Chmutova, Olga A. Lodochnikova, Rashid Z. Musin

Publikováno v: Journal of Chemistry, Vol 2018 (2018)

Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d226f285bdfda90fe7d39b06029ef6

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Stereochemistry of seven-membered heterocycles: XLVII. Synthesis, NMR, XRD, and theoretical investigation of monosulfoxides of (Z)-4,7-dihydro-1λ4,3-dithiepine series

Autor: O. I. Gnezdilov, E. N. Klimovitskii, S. G. Gnevashev, V. V. Gavrilov, A. N. Galyautdinova, Yu. G. Shtyrlin, Olga N. Kataeva, G. A. Chmutova, R. M. Vafina, Olga A. Lodochnikova

Publikováno v: Russian Journal of Organic Chemistry. 46:246-251

By oxidation of (Z)-4,7-dihydro-1,3-dithiepines with meta-chloroperbenzoic acid the corresponding 4,7-dihydro-1λ4,3-dithiepine 1-oxides were synthesized in ∼85% yield. A complete assignment of signals in the 1H and 13C NMR spectra of the compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd8fd6a236a91bc503b6ed1ffeca36b1
https://doi.org/10.1134/s107042801002017x

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Stereochemistry of seven-membered heterocycles: XLVI. Synthesis and dynamic 13C NMR spectroscopy of spiro[cyclohexane-1,4′-[3,5]dioxabicyclo[5.1.0]octanes]. DFT calculations of structurally related formaldehyde and acetone acetals

Autor: E. N. Klimovitskii, G. A. Chmutova, R. M. Vafina, V. V. Gavrilov, Vladimir V. Klochkov, Yu. G. Shtyrlin, M. N. Shamsutdinov

Publikováno v: Russian Journal of Organic Chemistry. 43:1846-1853

Spiro[cyclohexane-1,4′-[3,5]dioxabicyclo[5.1.0]octanes] were synthesized, and their conformational behavior was studied by dynamic 13C NMR spectroscopy. Anancomeric displacement of conformational equilibrium toward two nonequivalent twist conformer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e176cdedd8723d941eb830591979632b
https://doi.org/10.1134/s1070428007120196

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Synthesis and stereochemistry of 4-tert-butyl-4-oxo-3,5,8-trioxa (3,5-dioxa-8-thia)-4-phosphabicyclo [5.1.0]octanes and related acetals

Autor: Igor A. Litvinov, Roland Fröhlich, Alexey B. Dobrynin, V. V. Gavrilov, Yu. G. Shtyrlin, R. M. Vafina, V. Yu. Fedorenko, Olga N. Kataeva, E.A. Berdnikov, Alexander E. Klimovitskii, E. N. Klimovitskii

Publikováno v: Journal of Molecular Structure. 837:79-85

X-ray, 1H NMR and IR spectroscopy methods have been applied to a series of heterobicyclo[5.1.0]octanes. Endo epoxide and exo thiirane based on 2-tert-butyl-2-oxo-1,3,2-dioxaphosphepine exhibit chair form in a crystal state. Strong predominance of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baf996556bb6b62d5ff24a66358b5afc
https://doi.org/10.1016/j.molstruc.2006.09.033

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Stereochemistry of seven-membered heterocycles: XLV. Highly diastereoselective addition of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate to 2-substituted 1,3-dithiacyclohept-5-enes

Autor: R. M. Vafina, Igor A. Litvinov, Yu. G. Shtyrlin, Aidar T. Gubaidullin, Olga N. Kataeva, E. N. Klimovitskii

Publikováno v: Russian Journal of Organic Chemistry. 42:1563-1567

Conformationally heterogeneous 2-substituted 1,3-dithiacyclohept-5-enes (R = Ph, Me, t-Bu), which exist in solution as chair and boat conformers, react with dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with high exo-diastereoselectivity: only the cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b22f9d9e35be8851b919f825a32166f2
https://doi.org/10.1134/s1070428006100277

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Stereochemistry of Seven-membered Heterocycles: XLIV. Spatial Structure of 4-R-3,5-Dioxabicyclo[5.1.0]octanes

Autor: R. M. Vafina, Vladimir V. Klochkov, E. N. Klimovitskii, V. Yu. Fedorenko, B. I. Khairutdinov, Yu. G. Shtyrlin, R. N. Baryshnikov

Publikováno v: Russian Journal of Organic Chemistry. 41:293-297

4-R-3,5-Dioxabicyclo[5.1.0]octanes were prepared in good yields by reduction of the corresponding 8,8-dichloro derivatives in a system Li-t-BuOH. According to the data of dynamic 1H and 13CNMR spectroscopy involving experiments in the NOESY mode the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac2c6010ce9ab542f7a4a021c9c2cbe4
https://doi.org/10.1007/s11178-005-0160-8

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Stereochemistry of Seven-Membered Heterocycles: XLIII. Steric Structure of Diastereoisomeric 8,8-Dichloro(dibromo)-4-R-3,5-dioxabicyclo[5.1.0]octanes

Autor: Yu. G. Shtyrlin, V. Yu. Fedorenko, R. N. Baryshnikov, E. N. Klimovitskii, R. M. Vafina

Publikováno v: Russian Journal of Organic Chemistry. 39:1029-1033

Dichloro- and dibromocyclopropanation of 2-substituted 1,3-dioxacyclohept-5-enes according to Makosza resulted in formation of the corresponding 4-substituted 8,8-dichloro(dibromo)-3,5-dioxabicyclo[5.1.0]octanes in good yields. Ultrasonic activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11796be6fa3de56a971f2c63c1a2ee1e
https://doi.org/10.1023/b:rujo.0000003198.64663.ac

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