Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R. M. Renny Feldman"'
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2495 (2008)
The Amyloid Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of beta- and gamma-secretase, which result in the generation of toxic beta-amyloid (Abeta) peptides and a C-terminal fragment consisting of the intracel
Externí odkaz:
https://doaj.org/article/44e5b033c9204c2eabcd5ad6ffac1ab9
Publikováno v:
Human Molecular Genetics. 17:293-302
The majority of familial Alzheimer's disease (AD) cases are caused by mutations in presenilins, therefore, identifying regulators of presenilins is crucial for understanding AD pathogenesis. Ubiquilin 1 (UBQLN1) binds Presenilins in mammalian cells;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc4f1575c192b32fdf095449e7d8c0b
https://doi.org/10.1093/hmg/ddm305
https://doi.org/10.1093/hmg/ddm305
Autor:
John Keener, Ramzi Azzam, Wenying Shou, Harry Charbonneau, R. M. Renny Feldman, John DeModena, Raymond J. Deshaies, Georg J Hoppe, Kenji W Morimoto, Masayasu Nomura, Danesh Moazed, Edwin E. Traverso, Kathleen M. Sakamoto
Publikováno v:
Molecular Cell. 8(1):45-55
The budding yeast RENT complex, consisting of at least three proteins (Net1, Cdc14, Sir2), is anchored to the nucleolus by Net1. RENT controls mitotic exit, nucleolar silencing, and nucleolar localization of Nop1. Here, we report two new functions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cad67b8929da263fb6c7c1e2ba8a37
Autor:
Stephen Chen, Rati Verma, David Schieltz, R. M. Renny Feldman, Juergen Dohmen, Raymond J. Deshaies, John R. Yates
Publikováno v:
Molecular Biology of the Cell. 11:3425-3439
Ubiquitin-dependent proteolysis is catalyzed by the 26S proteasome, a dynamic complex of 32 different proteins whose mode of assembly and mechanism of action are poorly understood, in part due to the difficulties encountered in purifying the intact c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53affcf7f6dc40d094fda9db1e0cbaf
https://doi.org/10.1091/mbc.11.10.3425
https://doi.org/10.1091/mbc.11.10.3425
Publikováno v:
Cell. 91(2):221-230
In S. cerevisiae, the G1/S transition requires Cdc4p, Cdc34p, Cdc53p, Skp1p, and the Cln/Cdc28p cyclin-dependent kinase (Cdk). These proteins are thought to promote the proteolytic inactivation of the S-phase Cdk inhibitor Sic1p. We show here that Cd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c24085c25509a83a69e47599b34ce6
Autor:
Margaret L. Fahnestock, Linda O. Narhi, Pamela J. Bjorkman, Jennifer L. Johnson, Theodore J. Tsomides, John P. Mayer, R. M. Renny Feldman
Publikováno v:
Biochemistry. 33:8149-8158
Class I major histocompatibility complex (MHC) proteins present peptide antigens to T cells during the immune response against viruses. Peptides are loaded into newly synthesized class I heterodimers in the endoplasmic reticulum such that most or all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb61870ad17c1b4e52a7c8982906b12
https://doi.org/10.1021/bi00192a020
https://doi.org/10.1021/bi00192a020
Autor:
Jun R. Huh, R. M. Renny Feldman, Bruce A. Hay, Israel Muro, H.-Arno J. Müller, Hong Yu, Lijuan Wang, Soon Ji Yoo, Rollie J. Clem, Susan L. Wang
Publikováno v:
Nature cell biology. 4(6)
Inhibitor of apoptosis (IAP) proteins suppress apoptosis and inhibit caspases. Several IAPs also function as ubiquitin-protein ligases. Regulators of IAP auto-ubiquitination, and thus IAP levels, have yet to be identified. Here we show that Head invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2349697387066606311b54875db67e64
https://pubmed.ncbi.nlm.nih.gov/12021767
https://pubmed.ncbi.nlm.nih.gov/12021767
Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 proteolysis is mediated by the ubiquitin pathway and requires the action of CDC34,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4016a93999718f465e33cfeb76560574
https://resolver.caltech.edu/CaltechAUTHORS:VERmbc97
https://resolver.caltech.edu/CaltechAUTHORS:VERmbc97
Autor:
R. M. Renny Feldman, Jennifer L. Johnson, Margaret L. Fahnestock, William S. Lane, John M. Neveu, Pamela J. Bjorkman
Publikováno v:
Immunity. 3(5)
The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5379cc9addde221e9591937b70837b
https://pubmed.ncbi.nlm.nih.gov/7584148
https://pubmed.ncbi.nlm.nih.gov/7584148
Publikováno v:
PLoS ONE
PLoS ONE, Vol 3, Iss 6, p e2495 (2008)
PLoS ONE, Vol 3, Iss 6, p e2495 (2008)
The Amyloid Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of beta- and gamma-secretase, which result in the generation of toxic beta-amyloid (Abeta) peptides and a C-terminal fragment consisting of the intracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbb46aa30281f4cc903e7cc273cc96f
https://doi.org/10.1371/journal.pone.0002495
https://doi.org/10.1371/journal.pone.0002495