Zobrazeno 1 - 10
of 53
pro vyhledávání: '"R. M. Perlmutter"'
Publikováno v:
The Journal of Experimental Medicine
The nonreceptor protein tyrosine kinase p56lck (Lck) serves as a fundamental regulator of thymocyte development by delivering signals from the pre-T cell receptor (pre-TCR) that permit subsequent maturation. However, considerable evidence supports th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e138ae7a1495a33d40e32e6a9b9bff3
https://doi.org/10.1084/jem.184.3.931
https://doi.org/10.1084/jem.184.3.931
Publikováno v:
The Journal of Immunology. 155:1286-1295
The lymphocyte-specific proto-oncogene lck is transcribed from two developmentally regulated, independently functioning promoters. The proximal promoter is used in thymocytes, but not in peripheral T lymphocytes. The distal promoter operates in all s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad5d735ad1f6bc24dba6406c34231ae
https://doi.org/10.4049/jimmunol.155.3.1286
https://doi.org/10.4049/jimmunol.155.3.1286
Autor:
S Dziennis, C M Blosch, Daniel G. Tenen, H. L. Pahl, R M Perlmutter, Thomas L. Rothstein, D L Morris, R A Van Etten
Publikováno v:
Blood. 85:319-329
CD11b is the alpha chain of the Mac-1 integrin and is preferentially expressed in myeloid cells (neutrophils, monocytes, and macrophages). We have previously shown that the CD11b promoter directs cell-type- specific expression in myeloid lines using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f02aedc11bb81856327c2c20757707fb
https://doi.org/10.1182/blood.v85.2.319.319
https://doi.org/10.1182/blood.v85.2.319.319
Publikováno v:
International Immunology. 7:1529-1533
Engagement of CD40 by its ligand induces transcription of unrearranged Ig heavy chain genes, an initial step in switch recombination. The following studies were undertaken to understand the molecular basis of this response. Co-culture of S19 cells ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ead7a2f43394058b01a0c367b7ad97
https://doi.org/10.1093/intimm/7.9.1529
https://doi.org/10.1093/intimm/7.9.1529
Autor:
S, Takaki, K, Sauer, B M, Iritani, S, Chien, Y, Ebihara, K, Tsuji, K, Takatsu, R M, Perlmutter
Publikováno v:
Immunity. 13(5)
Lnk is an SH2 domain-containing adaptor protein expressed preferentially in lymphocytes. To illuminate the importance of Lnk, we generated lnk(-/-) mice. Whereas T cell development was unaffected, pre-B and immature B cells accumulated in the spleens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b5b4f8dfdf176d245e7db4bd8b6b9c9
https://pubmed.ncbi.nlm.nih.gov/11114373
https://pubmed.ncbi.nlm.nih.gov/11114373
Publikováno v:
Methods in enzymology. 327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9bee4c96715a7cbf931ae94ffaf1f09
https://pubmed.ncbi.nlm.nih.gov/11045000
https://pubmed.ncbi.nlm.nih.gov/11045000
Autor:
S D, Levin, R M, Koelling, S L, Friend, D E, Isaksen, S F, Ziegler, R M, Perlmutter, A G, Farr
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(2)
A novel cytokine from a thymic stromal cell line (thymic stromal lymphopoietin (TSLP)) promotes the development of B220+/IgM+ immature B cells when added to fetal liver cultures, long term bone marrow cultures, or bone marrow cells plated in semisoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65aa73dc929dfd863c172e2653db647f
https://pubmed.ncbi.nlm.nih.gov/9916685
https://pubmed.ncbi.nlm.nih.gov/9916685
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(5)
The tyrosine kinase Jak3 plays a key role in transducing signals from the IL-2, -4, -7, -9, and -15 receptors. Mice lacking Jak3 exhibit a profound, early block in both B and T cell development. To examine the mechanisms whereby Jak3 influences T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::548a3f74396b24958a8b5ebb9abf4f8e
https://pubmed.ncbi.nlm.nih.gov/9498750
https://pubmed.ncbi.nlm.nih.gov/9498750
Autor:
S, Takaki, J D, Watts, K A, Forbush, N T, Nguyen, J, Hayashi, J, Alberola-Ila, R, Aebersold, R M, Perlmutter
Publikováno v:
The Journal of biological chemistry. 272(23)
Stimulation of the T cell antigen receptor (TCR) activates a set of non-receptor protein tyrosine kinases that assist in delivering signals to the cell interior. Among the presumed substrates for these kinases, adaptor proteins, which juxtapose effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb0cb76abbaaaf62ff703da8f29c77e6
https://pubmed.ncbi.nlm.nih.gov/9169414
https://pubmed.ncbi.nlm.nih.gov/9169414
Autor:
H J, Fehling, B M, Iritani, A, Krotkova, K A, Forbush, C, Laplace, R M, Perlmutter, H, von Boehmer
Publikováno v:
Immunity. 6(6)
Mice deficient for the pre-TCR alpha (pT alpha) chain cannot form a pre-T cell receptor (TCR) and exhibit a severe defect in early T cell development, characterized by lack of "beta selection" and impaired generation of double-positive (DP) thymocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a066046ac660c2d7dbede2d591fccd83
https://pubmed.ncbi.nlm.nih.gov/9208843
https://pubmed.ncbi.nlm.nih.gov/9208843