Zobrazeno 1 - 9 of 9 pro vyhledávání: '"R. M. O'Doherty"'
1
Nutritional Regulation of Hypothalamic Leptin Receptor Gene Expression is Defective in Diet-Induced Obesity
Autor: A. Sahu, R. M. O'Doherty, L. Nguyen
Publikováno v: Journal of Neuroendocrinology. 14:887-893
Leptin action in the hypothalamus plays a critical role in maintaining normal food intake and body weight. Hyperleptinaemia is associated with obesity in humans and animal models, suggesting a state of leptin resistance. Although the mechanism of lep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e9e8eb6cc946acc9b2d30977722e558
https://doi.org/10.1046/j.1365-2826.2002.00856.x
Zobrazit plný text záznamu
2
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle
Autor: Agostino Consoli, Lawrence J. Mandarino, D. K. Granner, K. A. Cusi, C. Sewell, Haruhiko Osawa, R. M. O'Doherty, R. L. Printz, P. Kinchington, Ralph A. DeFronzo
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 269:E701-E708
Insulin regulates the activity of key enzymes of glucose metabolism in skeletal muscle by altering transcription or translation or by producing activity-altering modifications of preexisting enzyme molecules. Because of the small size of percutaneous
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86818e71e11648cf5aefc1760693e401
https://doi.org/10.1152/ajpendo.1995.269.4.e701
Zobrazit plný text záznamu
3
A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression
Autor: D K, Scott, J J, Collier, T T T, Doan, A S, Bunnell, M C, Daniels, D T, Eckert, R M, O'Doherty
Publikováno v: Molecular and cellular biochemistry. 254(1-2)
Hepatic genes crucial for carbohydrate and lipid homeostasis are regulated by insulin and glucose metabolism. However, the relative contributions of insulin and glucose to the regulation of metabolic gene expression are poorly defined in vivo. To add
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27bab161784a6422fe461cb01821b75a
https://pubmed.ncbi.nlm.nih.gov/14674713
Zobrazit plný text záznamu
4
Blunted fasting-induced decreases in plasma and CSF leptin concentrations in obese rats: the role of increased leptin secretion
Autor: L Nguyen, R M O'Doherty
Publikováno v: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 28(1)
Fasting substantially decreases plasma leptin concentration. However, in obesity, the fasting-induced decrease in leptin concentration is blunted or absent. The objective of the current study was to determine in diet-induced obese (DIO) rats the cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6553b4dbc6afd3b072bf9572aec31a
https://pubmed.ncbi.nlm.nih.gov/14569276
Zobrazit plný text záznamu
5
Nutritional regulation of hypothalamic leptin receptor gene expression is defective in diet-induced obesity
Autor: A, Sahu, L, Nguyen, R M, O'Doherty
Publikováno v: Journal of neuroendocrinology. 14(11)
Leptin action in the hypothalamus plays a critical role in maintaining normal food intake and body weight. Hyperleptinaemia is associated with obesity in humans and animal models, suggesting a state of leptin resistance. Although the mechanism of lep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebd2b8efdc6eb6ec04e0e3a4bbbcda6b
https://pubmed.ncbi.nlm.nih.gov/12421342
Zobrazit plný text záznamu
6
Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion
Autor: K, Trinh, C, Minassian, A J, Lange, R M, O'Doherty, C B, Newgard
Publikováno v: The Journal of biological chemistry. 272(40)
Glucose-6-phosphatase (Glu-6-Pase) catalyzes the terminal step of gluconeogenesis, the conversion of glucose 6-phosphate (Glu-6-P) to free glucose. This enzyme activity is thought to be conferred by a complex of proteins residing in the endoplasmic r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fe83d0fb936eb4fd62b242e3162836c
https://pubmed.ncbi.nlm.nih.gov/9312082
Zobrazit plný text záznamu
7
Role of the endocrine pancreas in control of fuel metabolism by the liver during exercise
Autor: D H, Wasserman, R M, O'Doherty, B A, Zinker
Publikováno v: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 19
The secretions of the pancreas drain into the portal vein just upstream of the liver. This anatomical arrangement is an important component of hepatic function since the pancreatic hormones are key regulators of intermediary metabolism in the liver.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5374a1ea2034fb416ea552a0fc349fe6
https://pubmed.ncbi.nlm.nih.gov/8581091
Zobrazit plný text záznamu
8
Hexokinase II mRNA and gene structure, regulation by insulin, and evolution
Autor: R L, Printz, S, Koch, L R, Potter, R M, O'Doherty, J J, Tiesinga, S, Moritz, D K, Granner
Publikováno v: The Journal of biological chemistry. 268(7)
A DNA segment that is highly conserved in glucokinase (hexokinase IV) and hexokinase I cDNA was used to identify specific cDNAs in a library prepared from rat adipose tissue mRNA. Some of these cDNAs were identified as being hexokinase I cDNA. Others
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa0b77a73f51b1052946a5acc6d12ecd
https://pubmed.ncbi.nlm.nih.gov/8444897
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje